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사람 치주염 병소의 치은 연하 치태에서 분리된 Veillonella atypica KHUD-V1의 유전체 염기서열 해독

Genome sequence of Veillonella atypica KHUD-V1 isolated from a human subgingival dental plaque of periodontitis lesion

  • 이재형 (경희대학교 치과대학 악안면생체공학교실) ;
  • 신승윤 (경희대학교 치과대학 치주과학교실) ;
  • 이한 (경희대학교 치과대학 악안면생체공학교실) ;
  • 양석빈 (경희대학교 치과대학 악안면생체공학교실) ;
  • 장은영 (경희대학교 대학원 치의학과) ;
  • 류재인 (경희대학교 치과대학 예방치과학교실) ;
  • 이진용 (경희대학교 치과대학 악안면생체공학교실) ;
  • 문지회 (경희대학교 치과대학 악안면생체공학교실)
  • Lee, Jae-Hyung (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Shin, Seung-Yun (Department of Periodontology, School of Dentistry, Kyung Hee University) ;
  • Lee, Han (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Yang, Seok Bin (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Jang, Eun-Young (Department of Dentistry, Graduate School, Kyung Hee University) ;
  • Ryu, Jae-In (Department of Preventive Dentistry, School of Dentistry, Kyung Hee University) ;
  • Lee, Jin-Yong (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Moon, Ji-Hoi (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University)
  • 투고 : 2018.11.26
  • 심사 : 2019.01.22
  • 발행 : 2019.03.31

초록

본 논문에서는 한국인 만성 치주염 환자의 치은연하치태에서 분리된 Veillonella atypica KHUD-V1의 유전체 서열을 보고한다. 다른 V. atypica 균주와 달리, KHUD-V1에서는 프로 파지 및 이와 관련된 것으로 추정되는 여러 병독성 인자가 확인되었다. V. atypica KHUD-V1 균주 및 이 균주의 유전체 서열정보는 Veillonella의 유전체 다양성을 진화론적 관점에서 이해하고, V. atypica의 병독성 및 유전적 다양성에 기여하는 프로파지의 역할을 연구하는데 유용할 것이다.

Here we report the genome sequence of Veillonella atypica strain KHUD-V1 isolated from subgingival dental plaque of Korean chronic periodontitis patients. Unlike other V. atypica strains, KHUD-V1 carries two prophage regions and prophage remnants, as well as several genes homologous to prophage-associated virulence factors, such as virulence-associated protein E, a Clp protease, and a toxin-antitoxin system. The isolate and its genome sequence obtained here will aid to understand the diversity of the genome architecture of Veillonella within an evolutionary framework and the role of prophages that contribute to the genetic diversity as well as the virulence of V. atypica.

키워드

MSMHBQ_2019_v55n1_77_f0001.png 이미지

Fig. 1. Prophages present in Veillonella atypica KHUD-V1.

Table 1. Genome features of Veillonella atypica KHUD-V1

MSMHBQ_2019_v55n1_77_t0001.png 이미지

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