Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers

  • Lee, Jinsoo (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) ;
  • Jeong, Ji-Seong (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) ;
  • Cho, Kyung-Jin (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) ;
  • Moon, Kyeong-Nang (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) ;
  • Kim, Sang Yun (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) ;
  • Han, Byungcheol (Fundamental Laboratory, R&D Headquarters, Korea Ginseng Corp.) ;
  • Kim, Yong-Soon (Chronic Inhalation Toxicity Research Center, Chemicals Toxicity Research Bureau, Occupational Safety and Health Research Institute, KOSHA) ;
  • Jeong, Eun Ju (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) ;
  • Chung, Moon-Koo (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) ;
  • Yu, Wook-Joon (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology)
  • Received : 2017.07.25
  • Accepted : 2017.12.27
  • Published : 2019.04.15
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Abstract

Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods: This study was conducted to evaluate the potential toxicological effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague-Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague-Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on maternal function and embryo-fetal development. Results and conclusion: No test item-related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have toxicological potential on developmental and reproductive functions. Therefore, no observed adverse effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.

Keywords

References

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