Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Superhongmi bran extract improves lipid profile and menopause symptoms: a randomized, placebo-controlled clinical trial

슈퍼홍미 미강 추출물의 폐경 후 여성의 혈중 지질 농도 및 대사성 질환 개선 효과

  • Chung, Soo Im (International Agricultural Training Center, Kyungpook National University) ;
  • Nam, Su Jin (Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National University) ;
  • Liang, Jie (Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National University) ;
  • Ma, Jing Wen (Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National University) ;
  • Kang, Mi Young (Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National University)
  • 정수임 (경북대학교 농업과학기술연구소) ;
  • 남수진 (경북대학교 식품영양학과) ;
  • ;
  • ;
  • 강미영 (경북대학교 식품영양학과)
  • Received : 2019.02.15
  • Accepted : 2019.03.28
  • Published : 2019.04.30
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Abstract

Women who undergo natural menopause transition have increased numbers of risk factors relating to metabolic syndrome due to estrogen deficiency. This study was conducted to investigate the effect of Superhongmi bran extract on metabolic syndrome improvement in menopausal women. Thirty women, who participated in a randomized, double-blind, placebo-controlled trial, were assigned to placebo-control (n=15) or Superhongmi bran extract (n=15) groups and were asked to consume two tablets (350 mg per extract per tablet) per day. After 12 weeks, weight, body mass index (BMI), plasma triglyceride (TG) levels, and total cholesterol (TC) levels were significantly decreased, whereas HDL-cholesterol (HDL-C), apolipoprotein A1 (ApoA1), adiponectin, superoxide dismutase 1 (SOD1), and GSH (glutathione) concentrations were significantly increased in the Superhongmi bran extract group. Moreover, $17{\beta}-estradiol$, and progesterone levels in the Superhongmi group were significantly higher than those in the placebo-control group. These results suggest that Superhongmi bran extract alleviates metabolic symptom in menopausal women.

본 연구는 슈퍼홍미 미강 추출물이 폐경 후 갱년기 증상에 및 대사 개선 효과를 확인하고자 수행되었다. 무월경이 지속된 지 5년 미만의 여성을 대상으로 12주동안 진행되었으며 위약대조군 15명, 실험군 15명으로 배정하였고, 1일 2개의 캡슐을 섭취하도록 하였다(슈퍼홍미 미강추출물 700 mg/day). 시험 종료 후 슈퍼홍미 미강 추출물 섭취군의 체중과 BMI 그리고 중성지질과 및 총콜레스테롤은 수준이 유의하게 감소하였다. 혈중 HDL 콜레스테롤과 ApoA1 농도는 약 10% 증가하여 지질대사 개선에 효과를 기대할 수 있었다. 항당뇨과 관련된 지표 중 혈중 glucose와 인슐린이 유의하게 감소하여 인슐린 저항성 지표인 HOMA-IR이 감소한 것을 확인할 수 있었고, 아디포넥틴 수준이 유의하게 증가하였으며, $TNF-{\alpha}$는 슈퍼홍미 미강 추출물 섭취군에서 투여 전보다 유의하게 감소하여 폐경 이후 당질대사 개선에 도움을 줄 수 있을 것으로 보인다. 항산화활성 분석 결과 SOD1, GSH 그리고 TBARS 수준이 실험군에서 감소하였으며, AOPP 는 유의적인 차이를 보이지 않았다. 여성호르몬 중 $17{\beta}-estradiol$과 progesterone 농도는 위약대조군에서 유의하게 감소하였으나 실험군은 섭취기간동안 호로몬 농도를 유지한 것으로 나타나 대조군에 비해 높은 수준을 나타났다. 폐경을 겪은 여성들은 여성호르몬 저하로 인해 갱년기 증상 및 대사증후군 발병 가능성이 증가하는데 슈퍼홍미 미강과 같은 기능성 식품 섭취로 대사증후군 위험인자들에 대한 호전이 높을 것이라 보고 이러한 연구 결과는 갱년기 여성 건강에 시사하는 바가 크다고 생각된다.

Keywords

Table 1. The average values of anthropometric measurements and changes after Superhongmi bran extract intakes

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Table 2. Changes of lipid metabolism in the plasma of menopausal women with Superhongmi bran extract intakes

SPGHB5_2019_v51n2_182_t0002.png 이미지

Table 3. Changes of glucose metabolism in the plasma of menopausal women with Superhongmi bran extract intakes

SPGHB5_2019_v51n2_182_t0003.png 이미지

Table 4. Antioxidant biomarkers in the plasma of menopausal women with Superhongmi bran extract intakes

SPGHB5_2019_v51n2_182_t0004.png 이미지

Table 5. 17-Beta Estradiol, Progesterone level in menopausal women with Superhongmi bran extract intakes

SPGHB5_2019_v51n2_182_t0005.png 이미지

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