DOI QR코드

DOI QR Code

The Case Report of Newborn Prenatally infected by Human Immunodeficiency Virus in Republic of Korea

  • Lee, Kyoung Eun (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Lee, Won Young (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Choi, Eui Kyung (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Shin, Jeong Hee (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Choi, Byung Min (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Kim, Yun-Kyung (Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine)
  • 투고 : 2018.09.11
  • 심사 : 2018.12.09
  • 발행 : 2019.04.25

초록

신생아의 태반을 통한 사람면역결핍바이러스 감염은 아프리카에서 흔하지만, 대한민국에서는 아직 보고된 적이 없다. 대한민국에서 사람면역결핍바이러스 감염자의 수는 증가하는 추세이며, 특히 생식연령에서의 사람면역결핍바이러스 감염자의 수가 증가하고 있다. 이는 사람면역결핍바이러스 수직 감염의 위험성을 높인다. 저자들은 아직 국내에 보고되지 않은 자궁 내 전파를 통한 신생아의 사람면역결핍바이러스 감염을 경험하였기에 보고하는 바이다. 자궁 내 전파를 통한 사람면역결핍바이러스 감염의 예후는 좋지 않으나 본 증례의 남아는 생후 9개월 경까지 정상 성장과 발달을 보였으며 특별한 의학적 문제가 없었다.

Trans-placental neonatal human immunodeficiency virus (HIV) infection is common in Africa; however, it is not yet reported in the Republic of Korea. With the increasing incidence of HIV infection, especially in the reproductive age group, the risk of the vertical transmission of HIV is also increasing. We report the first case of HIV infection acquired in-utero in a newborn in Korea. The baby is growing well with normal development.

키워드

참고문헌

  1. Marinda E, Humphrey JH, Iliff PJ, Mutasa K, Nathoo KJ, Piwoz EG, et al. Child mortality according to maternal and infant HIV status in Zimbabwe. Pediatr Infect Dis J 2007;26:519-26. https://doi.org/10.1097/01.inf.0000264527.69954.4c
  2. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 1994;331:1173-80. https://doi.org/10.1056/NEJM199411033311801
  3. Semrau K, Ghosh M, Kankasa C, Sinkala M, Kasonde P, Mwiya M, et al. Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feeding. J Acquir Immune Defic Syndr 2008;47:320-8. https://doi.org/10.1097/QAI.0b013e31815e7436
  4. The Working Group on Mother-To-Child Transmission of HIV. Rates of mother-to-child transmission of HIV-1 in Africa, America, and Europe: results from 13 perinatal studies. J Acquir Immune Defic Syndr Hum Retrovirol 1995;8:506-10. https://doi.org/10.1097/00042560-199504120-00011
  5. Lewis P, Nduati R, Kreiss JK, John GC, Richardson BA, Mbori-Ngacha D, et al. Cell-free human immunodeficiency virus type 1 in breast milk. J Infect Dis 1998;177:34-9. https://doi.org/10.1086/513816
  6. Park JW, Yang TW, Kim YK, Choi BM, Kim HJ, Park DW. Ten years of experience in the prevention of mother-to-child human immunodeficiency virus transmission in a university teaching hospital. Korean J Pediatr 2014;57:117-24. https://doi.org/10.3345/kjp.2014.57.3.117
  7. Sperling RS, Shapiro DE, Coombs RW, Todd JA, Herman SA, McSherry GD, et al. Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 1996;335:1621-9. https://doi.org/10.1056/NEJM199611283352201
  8. Cooper ER, Charurat M, Mofenson L, Hanson IC, Pitt J, Diaz C, et al. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr 2002;29:484-94. https://doi.org/10.1097/00042560-200204150-00009
  9. US Department of Health and Human Services, AIDSinfo. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States [Internet]. Bethesda (MD): National Institutes of Health; 2013 [cited 2018 Aug 9]. Available form: https://aidsinfo.nih.gov/contentfiles/lvguidelines/PerinatalGL.pdf.
  10. Garcia PM, Kalish LA, Pitt J, Minkoff H, Quinn TC, Burchett SK, et al. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. N Engl J Med 1999;341:394-402. https://doi.org/10.1056/NEJM199908053410602
  11. Bandura A. Social cognitive theory and exercise of control over HIV infection. In: DiClemente RJ, Peterson JL, editors. Preventing AIDS: theories and methods of behavioral interventions. New York (NY); Springer, 1994:25-59.
  12. Siegel JM, Angulo FJ, Detels R, Wesch J, Mullen A. AIDS diagnosis and depression in the Multicenter AIDS Cohort Study: the ameliorating impact of pet ownership. AIDS Care 1999;11:157-70. https://doi.org/10.1080/09540129948054
  13. Fitzgerald F, Penazzato M, Gibb D. Development of antiretroviral resistance in children with HIV in lowand middle-income countries. J Infect Dis 2013;207 Suppl 2:S85-92. https://doi.org/10.1093/infdis/jit115
  14. Kuhn L, Coovadia A, Strehlau R, Martens L, Hu CC, Meyers T, et al. Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitorbased regimen: long-term follow-up of a randomised, open-label trial. Lancet Infect Dis 2012;12:521-30. https://doi.org/10.1016/S1473-3099(12)70051-8

피인용 문헌

  1. Lamivudine/lopinavir/ritonavir/zidovudine : Development of resistance in HIV infection: case report vol.1756, pp.1, 2019, https://doi.org/10.1007/s40278-019-63083-z