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Convergent association between socioeconomic status and the blood concentrations of mercury, lead, and cadmium in the Korean adult population: based on the sixth Korea National Health and Nutritional Examination Surveys (KNHANES 2013-2015)

한국성인의 사회경제적수준과 혈중 중금속 농도의 융합적 분석

  • Kim, Junghyun (Department of Public Health, Graduate School of Public Health, Seoul National University) ;
  • Cho, Youngtae (Department of Public Health, Graduate School of Public Health, Seoul National University)
  • 김정현 (서울대학교 보건대학원 보건학과) ;
  • 조영태 (서울대학교 보건대학원 보건학과)
  • Received : 2019.01.30
  • Accepted : 2019.03.20
  • Published : 2019.05.28

Abstract

The purpose of this study was to investigate the association between socioeconomic status and blood heavy metal concentration in Korean adult population using the Korea National Health and Nutritional Examination Survey(KNHANES 2013-2015). Multiple logistic regression analysis was used to determine the association between socioeconomic status and the blood heavy metal concentration. Positive association was found between education and income level and blood concentration of mercury while those of lead and cadmium were negatively associated education and income level in Korean adult population (P for trend <0.001). At the point of an increase in the prevalence of heavy metal concentrations in the blood, a national public health policy will be needed to address the inequity of health due to socioeconomic factors.

본 연구는 사회경제적 상태의 지표인 교육수준 및 소득수준과 수은, 납, 카드뮴의 혈중 중금속 농도간의 관련성을 살펴보고자 하였다. 국민건강영양조사 2013-2015년 자료를 이용하여 성별에 따른 사회경제적상태와 혈중 중금속 농도간의 관련성을 분석하기 위해 로지스틱회귀분석을 실시하였다. 분석결과 한국성인의 교육과 소득수준이 높을수록 혈중 수은의 농도는 증가하는 경향이 나타났고, 혈중 납과 카드뮴의 농도는 감소하는 경향을 보였다 (P for trend <0.001). 혈중 중금속 농도의 유병률이 증가하고 있는 시점에서 사회경제적수준에 따른 건강불평등을 해결하기 위한 국가차원의 공중보건학적 정책이 필요할 것으로 사료된다.

Keywords

Table 1. General characteristics of study participants according to gender

OHHGBW_2019_v10n5_51_t0001.png 이미지

Table 2. Characteristics of study participants according to categories of household income

OHHGBW_2019_v10n5_51_t0002.png 이미지

Table 3. Characteristics of study participants according to categories of education level

OHHGBW_2019_v10n5_51_t0003.png 이미지

Table 4. The relationship between household income level and heavy metals concentration according to the demographic factors

OHHGBW_2019_v10n5_51_t0004.png 이미지

Table 5. Odds ratios and 95% confidence intervals of the level of Heavy metals among Korean adults across categories of SES

OHHGBW_2019_v10n5_51_t0005.png 이미지

References

  1. F. Fuentes-Gandara, J. Pinedo-Hernndez, J. Marrugo-Negrete & S. Dez. (2018). Human health impacts of exposure to metals through extreme consumption of fish from the Colombian Caribbean Sea. Environmental geochemistry and health, 40(1), 229-242. https://doi.org/10.1007/s10653-016-9896-z
  2. R. Figueroa, D. Caicedo, G. Echeverry, M. Pea & F. Mndez. (2017). Socioeconomic status, eating patterns, and heavy metals exposure in women of childbearing age in Cali, Colombia, Biomedica: revista del Instituto Nacional de Salud, 37(3), 341-352.
  3. S. M. Park & B. K. Lee. (2013). Body fat percentage and hemoglobin levels are related to blood lead, cadmium, and mercury concentrations in a Korean Adult Population (KNHANES 2008-2010). Biological trace element research, 151(3), 315-323. https://doi.org/10.1007/s12011-012-9566-7
  4. I. Y. Yoo. (2014). The Blood levels of lead, mercury, and cadmium and metabolic syndrome of Korean adults. Journal of The Korean Society of Living Environmental System, 21(2), 251-259. https://doi.org/10.21086/ksles.2014.04.21.2.251
  5. X. Xufeng, Z. Lou, G. Christakos, Z. Ren, Q. Liu & X. Lv. (2018). The association between heavy metal soil pollution and stomach cancer: A case study in Hangzhou city, China. Environmental geochemistry and health, 40(6), 2481-2490. https://doi.org/10.1007/s10653-018-0113-0
  6. R. Chowdhury et al. (2018). Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis. bmj, 362, k3310. https://doi.org/10.1136/bmj.k3310
  7. A. Jan, M. Azam, K. Siddiqui, A. Ali, I. Choi & Q. Haq. (2015). Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants. International journal of molecular sciences, 16(12), 29592-29630. https://doi.org/10.3390/ijms161226183
  8. K. Jomova & M. Valko. (2011). Advances in metal-induced oxidative stress and human disease. Toxicology, 283(2-3), 65-87. https://doi.org/10.1016/j.tox.2011.03.001
  9. A. Bhatnagar. (2006). Environmental cardiology: studying mechanistic links between pollution and heart disease. Circulation research, 99(7), 692-705. https://doi.org/10.1161/01.RES.0000243586.99701.cf
  10. P. Muntner, A. Menke, K. B. DeSalvo, F. A. Rabito & V. Batuman. (2005). Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys. Archives of Internal Medicine,165(18), 2155-2161. https://doi.org/10.1001/archinte.165.18.2155
  11. J. W. Seo et al. (2015). Trend of blood lead, mercury, and cadmium levels in Korean population: data analysis of the Korea National Health and Nutrition Examination Survey. Environmental monitoring and assessment, 187(3), 1-13. https://doi.org/10.1007/s10661-014-4167-x
  12. W. McKelvey et al. (2007). A biomonitoring study of lead, cadmium, and mercury in the blood of New York city adults. Environmental Health Perspectives, 115(10), 1435-1441. https://doi.org/10.1289/ehp.10056
  13. C. M. L. Carvalho, A. I. N. M. Matos, M. L. Mateus, A. P. M. Santos & M. C. C. Batoreu. (2008). High-fish consumption and risk prevention: assessment of exposure to methylmercury in Portugal. Journal of Toxicology and Environmental Health, Part A, 71(18), 1279-1288. https://doi.org/10.1080/15287390801989036
  14. N. S. Kim & B. K. Lee. (2011). National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population. International archives of occupational and environmental health, 84(1), 53-63. https://doi.org/10.1007/s00420-010-0522-6
  15. K. Nomiyama, H. Nomiyama, S. J. Liu, Y. X. Tao, T. Nomiyama & K. Omae. (2002). Lead induced increase of blood pressure in female lead workers. Occupational and Environmental Medicine, 59(11), 734-738. https://doi.org/10.1136/oem.59.11.734
  16. J. S. Oh & S. H. Lee. (2015). Pb, Hg and Cd concentration of blood and exposure-related factors. Korea Academy Industrial Cooperation Society, 16(3), 2089-2099. https://doi.org/10.5762/KAIS.2015.16.3.2089
  17. H. Bjermo et al. (2013). Lead, mercury, and cadmium in blood and their relation to diet among Swedish adults. Food and Chemical Toxicology, 57, 161-169. DOI: http://dx.doi.org/10.1016/j.fct.2013.03.024
  18. B. R. Lee & J. H. Ha. (2011). The Effects of Smoking and Drinking on Blood Lead and Cadmium Levels: Data from the Fourth Korea National Health and Nutrition Examination Survey. Korean J Occup Environ Med, 23(1), 31-41. https://doi.org/10.35371/kjoem.2011.23.1.31
  19. J. Y. Shin, J. M. Kim & Y. R. Kim. (2012). The association of heavy metals in blood, fish consumption frequency, and risk of cardiovascular diseases among Korean adults: The Korea National Health and Nutrition Examination Survey(2008-2010). Korean J Nutr, 45(4), 347-361. DOI: http://dx.doi.org/10.4163/kjn.2012.45.4.347
  20. T. A. Ozden et al. (2007). Elevated hair levels of cadmium and lead in school children exposed to smoking and in highways near schools. Clinical biochemistry , 40(1-2), 52-56 https://doi.org/10.1016/j.clinbiochem.2006.07.006
  21. M. Vrijheid et al. (2012). Socioeconomic status and exposure to multiple environmental pollutants during pregnancy: evidence for environmental inequity?. J Epidemiol Community Health, 66(2),106-113. https://doi.org/10.1136/jech.2010.117408
  22. B. Morrens et al. (2012). Social distribution of internal exposure to environmental pollution in Flemish adolescents. International journal of hygiene and environmental health, 215(4), 474-481. https://doi.org/10.1016/j.ijheh.2011.10.008
  23. L. S. Morales, P. Gutierrez & J. J. Escarce. (2005). Demographic and socioeconomic factors associated with blood lead levels among mexican-american children and adolescents in the united states. Public Health Reports, 120(4), 448-454. https://doi.org/10.1177/003335490512000412
  24. H. J. Jin & S. M. Cho. (2016). Estimation of Socio-economic Costs of Illness due to Blood Concentration of Heavy Metals in Koreans among the Public. Health and social welfare review, 36(4), 508-536. https://doi.org/10.15709/hswr.2016.36.4.508
  25. J. L. Peters et al. (2011). Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. American journal of epidemiology, 174(12), 1345-1353. https://doi.org/10.1093/aje/kwr269
  26. S. M. Bernard & M. A. McGeehin. (2003). Prevalence of blood lead levels${\geq}$5${\mu}$g/dL among US children 1 to 5 years of age and socioeconomic and demographic factors associated with blood of lead levels 5 to $10{\mu}g/dL$, Third National Health and Nutrition Examination Survey, 1988-1994. Pediatrics, 112(6), 1308-1313. https://doi.org/10.1542/peds.112.6.1308
  27. J. Kim, M. Shin, S. Kim, J. Seo, H. Ma & Y. J. Yang. (2017). Association of iron status and food intake with blood heavy metal concentrations in Korean adolescent girls and women : Based on the 2010-2011 Korea National Health and Nutrition Examination Survey. Journal of Nutrition and Health, 50(4), 350-360. https://doi.org/10.4163/jnh.2017.50.4.350
  28. M. H. Kang, S. M. Park, D. N. Oh, M. H. Kim & M. K. Choi. (2013). Dietary nutrient and food intake and their relations with serum heavy metals in osteopenic and osteoporotic patients. Clin Nutr Res, 2(1), 26-33. https://doi.org/10.7762/cnr.2013.2.1.26
  29. K. Osman, J. E. Zejda, A. Schutz, D. Mielzynska, C. G. Elinder & M. Vahter. (1998). Exposure to lead and other metals in children from Katowice district, Poland, International archives of occupational and environmental health, 71(3), 180-186. https://doi.org/10.1007/s004200050268
  30. S. Elreedy, N. Krieger, P. B. Ryan, D. Sparrow, S. T. Weiss & H. Hu. (1999). Relations between individual and neighborhood-based measures of socioeconomic position and bone lead concentrations among community-exposed men: the Normative Aging Study. American Journal of Epidemiology, 150(2), 129-141. https://doi.org/10.1093/oxfordjournals.aje.a009972
  31. J. M. Hightower & D. Moore. (2003). Mercury levels in high-end consumers of fish. Environmental health perspectives, 111(4), 604-608. https://doi.org/10.1289/ehp.5837
  32. E. Oken et al. (2008). Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. American journal of epidemiology, 167(10), 1171-1181. https://doi.org/10.1093/aje/kwn034
  33. S. Lim, H. U. Chung, D. Paek. (2010). Low dose mercury and heart rate variability among community residents nearby to an industrial complex in Korea. Neurotoxicology, 31(1), 10-16. https://doi.org/10.1016/j.neuro.2009.10.001
  34. M. A. Serdar et al. (2012). The correlation between smoking status of family members and concentrations of toxic trace elements in the hair of children. Biological trace element research, 148(1), 11-17. https://doi.org/10.1007/s12011-012-9337-5
  35. E. Barany et al. (2002). Trace elements in blood and serum of Swedish adolescents: relation to gender, age, residential area, and socioeconomic status. Environmental research, 89(1), 72-84. https://doi.org/10.1006/enrs.2002.4351