Diabetes and Metabolism Journal

Korean Diabetes Association (대한당뇨병학회)
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Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity

  • Song, Sun Ok (Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System) ;
  • He, Ken (Sleep Medicine Section, Veterans Affairs Pittsburgh Healthcare System) ;
  • Narla, Radhika R. (Department of Medicine, University of Washington School of Medicine) ;
  • Kang, Hyun Goo (Department of Neurology, Chonbuk National University Medical School) ;
  • Ryu, Han Uk (Department of Neurology, Chonbuk National University Medical School) ;
  • Boyko, Edward J. (Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System)
  • Received : 2018.12.09
  • Accepted : 2019.02.19
  • Published : 2019.04.30
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Abstract

Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. However, OSA and diabetes have a high prevalence rate in public and shares the common overlap characteristic and risk factors such as age, obesity, and metabolic syndrome that make it difficult to establish the exact pathophysiologic mechanism between them. In addition, studies demonstrating that treatment of OSA may help prevent diabetes or improve glycemic control have not shown convincing result but have become a great field of interest research. This review outlines the bidirectional correlation between OSA and diabetes and explore the pathophysiologic mechanisms by approaching their basic etiologies.

Keywords

References

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