Acknowledgement
This study was approved by the Institutional Review Board of The Catholic University of Korea Seoul St. Mary's Hospital with a waiver of informed consent (KC18SNDI0512).
References
- McCorduck P. Machines who think: a personal inquiry into the history and prospects of artificial intelligence. Natick: A.K. Peters, 2004.
- Turing AM. I. Computing machinery and intelligence. Mind 1950; 59: 433-60. https://doi.org/10.1093/mind/LIX.236.433
- Searle JR. Minds, brains, and programs. Behav Brain Sci 1980; 3: 417-24. https://doi.org/10.1017/S0140525X00005756
- Russell SJ, Norvig P. Artificial intelligence: a modern approach. Upper Saddle River: Prentice Hall, 2003.
- Artificial intelligence [Internet]. Wikipedia, 2018 [cited 2018 Dec 9]. Available from: https://en.wikipedia.org/wiki/Artificial_intelligence.
- Mortensen TL, Watt DL, Leistritz FL. Loan default prediction using logistic regression and a loan pricing model. Report No. 119549 [Internet]. Fargo: North Dakota State University, 1988 [cited 2018 Dec 7]. Available from: https://ideas.repec.org/p/ags/nddmrs/119549.html.
- Graham P. Better Bayesian filtering [Internet]. PAUL GRAHAM, 2003 [cited 2018 Nov 22]. Available from: http://www.paulgraham.com/better.html.
- Krizhevsky A, Sutskever I, Hinton GE. ImageNet classification with deep convolutional neural networks. In: Pereira F, Burges CJ, Bottou L, Weinberger KQ, eds. Advances in neural information processing systems 25. Red Hook: Curran Associates, Inc., 2012; 1097-105.
- Mnih V, Kavukcuoglu K, Silver D, et al. Human-level control through deep reinforcement learning. Nature 2015; 518: 529-33. https://doi.org/10.1038/nature14236
- Silver D, Schrittwieser J, Simonyan K, et al. Mastering the game of Go without human knowledge. Nature 2017; 550: 354-9. https://doi.org/10.1038/nature24270
- Hannun A, Case C, Casper J, et al. Deep speech: scaling up end-toend speech recognition [Internet]. Ithaca: arXiv, Cornell University, 2014 [cited 2018 Nov 22]. Available from: http://arxiv.org/abs/ 1412.5567.
- Luong MT, Pham H, Manning CD. Effective approaches to attention-based neural machine translation. In: Proceedings of the 2015 Conference on Empirical Methods in Natural Language Processing, 2015 Sep 17-21, Lisbon, Portugal. Stroudsburg: Association for Computational Linguistics, 2015; 1412-21.
- Wu Y, Schuster M, Chen Z, et al. Google's neural machine translation system: bridging the gap between human and machine translation [Internet]. Ithaca: arXiv, Cornell University, 2016 [cited 2018 Nov 22]. Available from: http://arxiv.org/abs/1609.08144.
- Antol S, Agrawal A, Lu J, et al. VQA: visual question answering. In: Proceedings of the IEEE International Conference on Computer Vision, 2015 Dec 7-13, Santiago, Chile. Washington, DC: IEEE Computer Society, 2015; 2425-33.
- Kim JH, Lee SW, Kwak D, et al. Multimodal residual learning for visual QA. In: Lee DD, von Luxburg U, Garnett R, et al., eds. Advances in neural information processing systems 29. Red Hook: NY Curran Associates Inc., 2016; 361-9.
- LeCun Y, Bottou L, Bengio Y, Haffner P. Gradient-based learning applied to document recognition. Proc IEEE 1998; 86: 2278-324. https://doi.org/10.1109/5.726791
- Szegedy C, Liu W, Jia Y, et al. Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2015 Jun 7-12, Boston, MA, USA. Silver Spring: IEEE Computer Society Press, 2015; 1-9.
- LeCun Y, Bengio Y, Hinton G. Deep learning. Nature 2015; 521: 436-44. https://doi.org/10.1038/nature14539
- Hochreiter S, Schmidhuber J. Long short-term memory. Neural Comput 1997; 9: 1735-80. https://doi.org/10.1162/neco.1997.9.8.1735
- Weizenbaum J. ELIZA: a computer program for the study of natural language communication between man and machine. Commun ACM 1966; 9: 36-45. https://doi.org/10.1145/365153.365168
- Shortliffe EH. Mycin: a knowledge-based computer program applied to infectious diseases. In: Proceedings of the Annual Symposium on Computer Application in Medical Care, 1977 Oct 3-5, Washington, DC, USA. New York: Institute of Electrical and Electronics Engineers, 1977; 66-9.
- Heckerman DE, Horvitz EJ, Nathwani BN. Toward normative expert systems: Part I. The Pathfinder project. Methods Inf Med 1992; 31: 90-105. https://doi.org/10.1055/s-0038-1634867
- Heckerman DE, Nathwani BN. Toward normative expert systems: Part II. Probability-based representations for efficient knowledge acquisition and inference. Methods Inf Med 1992; 31: 106-16. https://doi.org/10.1055/s-0038-1634868
- Vyborny CJ, Giger ML. Computer vision and artificial intelligence in mammography. AJR Am J Roentgenol 1994; 162: 699-708. https://doi.org/10.2214/ajr.162.3.8109525
- Kononenko I. Machine learning for medical diagnosis: history, state of the art and perspective. Artif Intell Med 2001; 23: 89-109. https://doi.org/10.1016/S0933-3657(01)00077-X
- Baker JA, Rosen EL, Lo JY, Gimenez EI, Walsh R, Soo MS. Computeraided detection (CAD) in screening mammography: sensitivity of commercial CAD systems for detecting architectural distortion. AJR Am J Roentgenol 2003; 181: 1083-8. https://doi.org/10.2214/ajr.181.4.1811083
- Gulshan V, Peng L, Coram M, et al. Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA 2016; 316: 2402-10. https://doi.org/10.1001/jama.2016.17216
- Litjens G, Kooi T, Bejnordi BE, et al. A survey on deep learning in medical image analysis. Med Image Anal 2017; 42: 60-88. https://doi.org/10.1016/j.media.2017.07.005
- Kohli M, Prevedello LM, Filice RW, Geis JR. Implementing machine learning in radiology practice and research. AJR Am J Roentgenol 2017; 208: 754-60. https://doi.org/10.2214/AJR.16.17224
- Shaikhina T, Khovanova NA. Handling limited datasets with neural networks in medical applications: a small-data approach. Artif Intell Med 2017; 75: 51-63. https://doi.org/10.1016/j.artmed.2016.12.003
- Angermueller C, Parnamaa T, Parts L, Stegle O. Deep learning for computational biology. Mol Syst Biol 2016; 12: 878. https://doi.org/10.15252/msb.20156651
- Torkamani A, Andersen KG, Steinhubl SR, Topol EJ. High-definition medicine. Cell 2017; 170: 828-43. https://doi.org/10.1016/j.cell.2017.08.007
- Wainberg M, Merico D, Delong A, Frey BJ. Deep learning in biomedicine. Nat Biotechnol 2018; 36: 829-38. https://doi.org/10.1038/nbt.4233
- Xiong HY, Alipanahi B, Lee LJ, et al. RNA splicing: the human splicing code reveals new insights into the genetic determinants of disease. Science 2015; 347: 1254806. https://doi.org/10.1126/science.1254806
- Poplin R, Chang PC, Alexander D, et al. A universal SNP and smallindel variant caller using deep neural networks. Nat Biotechnol 2018; 36: 983-7. https://doi.org/10.1038/nbt.4235
- Rajkomar A, Oren E, Chen K, et al. Scalable and accurate deep learning with electronic health records. NPJ Digit Med 2018; 1: 18. https://doi.org/10.1038/s41746-018-0029-1
- Fernandes K, Chicco D, Cardoso JS, Fernandes J. Supervised deep learning embeddings for the prediction of cervical cancer diagnosis. PeerJ Comput Sci 2018; 4: e154. https://doi.org/10.7717/peerj-cs.154
- Ye JJ. Artificial intelligence for pathologists is not near: it is here: description of a prototype that can transform how we practice pathology tomorrow. Arch Pathol Lab Med 2015; 139: 929-35. https://doi.org/10.5858/arpa.2014-0478-OA
- Beck JR, Salem DN, Estes NA, Pauker SG. A computer-based Markov decision analysis of the management of symptomatic bifascicular block: the threshold probability for pacing. J Am Coll Cardiol 1987; 9: 920-35. https://doi.org/10.1016/S0735-1097(87)80251-6
- Schaefer AJ, Bailey MD, Shechter SM, Roberts MS. Modeling medical treatment using Markov decision processes. In: Brandeau ML, Sainfort F, Pierskalla WP, eds. Operations research and health care: a handbook of methods and applications. Boston: Kluwer Academic Publisher, 2004; 593-612.
- Alagoz O, Hsu H, Schaefer AJ, Roberts MS. Markov decision processes: a tool for sequential decision making under uncertainty. Med Decis Making 2010; 30: 474-83. https://doi.org/10.1177/0272989X09353194
- Harbias A, Salmo E, Crump A. Implications of observer variation in Gleason scoring of prostate cancer on clinical management: a collaborative audit. Gulf J Oncolog 2017; 1: 41-5.
- Ozkan TA, Eruyar AT, Cebeci OO, Memik O, Ozcan L, Kuskonmaz I. Interobserver variability in Gleason histological grading of prostate cancer. Scand J Urol 2016; 50: 420-4. https://doi.org/10.1080/21681805.2016.1206619
- Janowczyk A, Madabhushi A. Deep learning for digital pathology image analysis: a comprehensive tutorial with selected use cases. J Pathol Inform 2016; 7: 29. https://doi.org/10.4103/2153-3539.186902
- Komura D, Ishikawa S. Machine learning methods for histopathological image analysis. Comput Struct Biotechnol J 2018; 16: 34-42. https://doi.org/10.1016/j.csbj.2018.01.001
- Garud H, Karri SP, Sheet D, et al. High-magnification multi-views based classification of breast fine needle aspiration cytology cell samples using fusion of decisions from deep convolutional networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2017 Jul 21-26, Honolulu, HI, USA. New York: Institute of Electrical and Electronics Engineers, 2017; 828-33.
- Li Y, Ping W. Cancer metastasis detection with neural conditional random field [Internet]. Ithaca: arXiv, Cornell University, 2018 [cited 2018 Nov 22]. Available from: http://arxiv.org/abs/1806.07064.
- Rannen Triki A, Blaschko MB, Jung YM, et al. Intraoperative margin assessment of human breast tissue in optical coherence tomography images using deep neural networks. Comput Med Imaging Graph 2018; 69: 21-32. https://doi.org/10.1016/j.compmedimag.2018.06.002
- Ehteshami Bejnordi B, Mullooly M, Pfeiffer RM, et al. Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic breast biopsies. Mod Pathol 2018; 31: 1502-12. https://doi.org/10.1038/s41379-018-0073-z
- Litjens G, Sanchez CI, Timofeeva N, et al. Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis. Sci Rep 2016; 6: 26286. https://doi.org/10.1038/srep26286
- Ciresan DC, Giusti A, Gambardella LM, Schmidhuber J. Mitosis detection in breast cancer histology images with deep neural networks. Med Image Comput Comput Assist Interv 2013; 16: 411-8.
- Teramoto A, Tsukamoto T, Kiriyama Y, Fujita H. Automated classification of lung cancer types from cytological images using deep convolutional neural networks. Biomed Res Int 2017; 2017: 4067832.
- Yu KH, Zhang C, Berry GJ, et al. Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features. Nat Commun 2016; 7: 12474. https://doi.org/10.1038/ncomms12474
- Coudray N, Ocampo PS, Sakellaropoulos T, et al. Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning. Nat Med 2018; 24: 1559-67. https://doi.org/10.1038/s41591-018-0177-5
- Campanella G, Silva VW, Fuchs TJ. Terabyte-scale deep multiple instance learning for classification and localization in pathology [Internet]. Ithaca: arXiv, Cornell University, 2018 [cited 2018 Nov 22]. Available from: http://arxiv.org/abs/1805.06983.
- Arvaniti E, Fricker KS, Moret M, et al. Automated Gleason grading of prostate cancer tissue microarrays via deep learning. Sci Rep 2018; 8: 12054. https://doi.org/10.1038/s41598-018-30535-1
- Zhou N, Fedorov A, Fennessy F, Kikinis R, Gao Y. Large scale digital prostate pathology image analysis combining feature extraction and deep neural network [Internet]. Ithaca: arXiv, Cornell University, 2017 [cited 2018 Nov 22]. Available from: http://arxiv.org/abs/ 1705.02678.
- Nagpal K, Foote D, Liu Y, et al. Development and validation of a deep learning algorithm for improving Gleason scoring of prostate cancer [Internet]. Ithaca: arXiv, Cornell University, 2018 [cited 2018 Nov 22]. Available from: http://arxiv.org/abs/1811.06497.
- Ertosun MG, Rubin DL. Automated grading of gliomas using deep learning in digital pathology images: a modular approach with ensemble of convolutional neural networks. AMIA Annu Symp Proc 2015; 2015: 1899-908.
- Mobadersany P, Yousefi S, Amgad M, et al. Predicting cancer outcomes from histology and genomics using convolutional networks. Proc Natl Acad Sci U S A 2018; 115: E2970-E9. https://doi.org/10.1073/pnas.1717139115
- Wu M, Yan C, Liu H, Liu Q. Automatic classification of ovarian cancer types from cytological images using deep convolutional neural networks. Biosci Rep 2018; 38: BSR20180289. https://doi.org/10.1042/BSR20180289
- Zhang L, Lu L, Nogues I, Summers RM, Liu S, Yao J. DeepPap: deep convolutional networks for cervical cell classification. IEEE J Biomed Health Inform 2017; 21: 1633-43. https://doi.org/10.1109/JBHI.2017.2705583
- Xu M, Papageorgiou DP, Abidi SZ, Dao M, Zhao H, Karniadakis GE. A deep convolutional neural network for classification of red blood cells in sickle cell anemia. PLoS Comput Biol 2017; 13: e1005746. https://doi.org/10.1371/journal.pcbi.1005746
- Meier A, Nekolla K, Earle S, et al. End-to-end learning to predict survival in patients with gastric cancer using convolutional neural networks. Ann Oncol 2018; 29(Suppl 8): mdy269.075.
- Xie W, Noble JA, Zisserman A. Microscopy cell counting and detection with fully convolutional regression networks. Comput Methods Biomech Biomed Eng Imaging Vis 2016; 6: 283-92.
- Tuominen VJ, Ruotoistenmaki S, Viitanen A, Jumppanen M, Isola J. ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67. Breast Cancer Res 2010; 12: R56. https://doi.org/10.1186/bcr2615
- Meijering E. Cell segmentation: 50 years down the road [life sciences]. IEEE Signal Process Mag 2012; 29: 140-5. https://doi.org/10.1109/MSP.2012.2204190
- Ruifrok AC, Johnston DA. Quantification of histochemical staining by color deconvolution. Anal Quant Cytol Histol 2001; 23: 291-9.
- Otsu N. A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern 1979; 9: 62-6. https://doi.org/10.1109/TSMC.1979.4310076
- Zhang L, Sonka M, Lu L, Summers RM, Yao J. Combining fully convolutional networks and graph-based approach for automated segmentation of cervical cell nuclei. In: 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017), 2017 Apr 18-21, Melbourne, VIC, Australia. New York: Institute of Electrical and Electronics Engineers, 2017; 406-9.
- Chen H, Qi X, Yu L, Heng PA. DCAN: deep contour-aware networks for accurate gland segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2016 Jun 27- 30, Las Vegas, NV, USA. New York: Institute of Electrical and Electronics Engineers, 2016; 2487-96.
- CAMELYON16 Consortium. CAMELYON16. CAMELYON16 ISBI challenge on cancer metastasis detection in lymph node, 2015 [Internet]. Grand-Challenges, 2016 [cited 2018 Nov 22]. Available from: https://camelyon16.grand-challenge.org/.
- The Cancer Genome Atlas [Internet]. Bethesda: The Cancer Genome Atlas, National Cancer Institute, 2011 [cited 2018 Nov 22]. Available from: https://cancergenome.nih.gov/.
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