Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지
DOI QR코드

DOI QR Code

Experimental Study Trends on the Acupuncture Moxibustion Treatment for Visceral Hypersensitivity: Based on the Data of PubMed

내장감각과민의 침구 치료에 대한 실험연구 현황: PubMed를 중심으로

  • Han, Chang Woo (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Choi, Jun-Yong (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Park, Seong Ha (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kim, So Yeon (Department of Internal Medicine, Korean Medicine Hospital of Pusan National University)
  • 한창우 (부산대학교 한방병원 한방내과) ;
  • 최준용 (부산대학교 한방병원 한방내과) ;
  • 박성하 (부산대학교 한방병원 한방내과) ;
  • 김소연 (부산대학교 한방병원 한방내과)
  • Received : 2019.02.25
  • Accepted : 2019.03.18
  • Published : 2019.06.27
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The aim of this study is to review the current trends in experimental studies on the acupuncture moxibustion treatment for visceral hypersensitivity. Methods : PubMed was searched for experimental studies about visceral hypersensitivity and acupuncture/moxibustion. Data were extracted and tabulated from the selected articles about experimental method, intervention, result and mechanism. Results : Total 23 articles were reviewed. Chronic visceral hypersensitivity animal model was applied in 17 studies (74%). Visceral hypersensitivity was measured by abdominal withdrawal reflex scoring or/and abdominal electromyogram. Acupoints like ST25, ST36, ST37, BL25, LI11, BL32 and PC6 were treated by electroacupuncture or moxibustion. All articles reported that electroacupuncture or moxibustion treatment is significantly effective in reducing visceral hypersensitivity. Treatment mechanisms were studied, related to mast cell, serotonin (5-HT) and receptor (5-HT3R and 5-HT4R), substance P (SP), vasoactive intestinal polypeptide (VIP), c-fos positive cell, corticotropin-releasing hormone (CRH), purinergic 2X (P2X)2, P2X3, P2X4, P2X7, N-methyl-D-aspartate (NMDA) receptor (NR1 and NR2B), prokinectin (PK) 1 and PK2. Conclusions : Evidences on acupuncture/moxibustion treatment for visceral hypersensitivity in animal studies warrant more research on effective acupoins, electro-acupuncture methods and treatment durations.

Keywords

References

  1. Lee OY. Visceral Hypersensitivity in Irritable Bowel Syndrome. Journal of Neurogastroenterology and Motility Spring Conference. 2002 ; 14 : 225-35.
  2. Oh JH, Kwon JG. Functional Dyspepsia. Korean J Gastroenterol. 2019 ; 73(2) : 77-83. https://doi.org/10.4166/kjg.2019.73.2.77
  3. Kim JH, Sung IK. Strategy to Manage Irritable Bowel Syndrome in Korea. Korean J Internal Medicine. 2014 ; 86(6) : 695-7. https://doi.org/10.3904/kjm.2014.86.6.695
  4. Department of Gastroenterology of Korean Medicine, Korean Medicine Gastroenterogy. Seoul: Koonja. 2008: 415.
  5. Kim BY, Seo BN, Park JE, Yang CS, Kim YT, Im JW, et al. A Systematic Review of Acupuncture-Moxibution Treatment for Functional Dyspepsia. Korean Journal of Acupuncture. 2017 ; 34(1) : 8-36. https://doi.org/10.14406/acu.2016.030
  6. Wu IXY, Wong CHL, Ho RST, Cheung WKW, Ford AC, Wu JCY, et al. Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis. Therap Adv Gastroenterol. 2019 ; 12 : 1756284818820438. https://doi.org/10.1177/1756284818820438
  7. Pei L, Chen H, Guo J, Chen L, Wu X, Xu W, et al. Effect of acupuncture and its influence on visceral hypersensitivity in IBS-D patients: Study protocol for a randomized controlled trial. Medicine (Baltimore). 2018 ; 97(21) : e10877. https://doi.org/10.1097/md.0000000000010877
  8. Zhang F, Wu L, Zhao J, Lv T, Hu Z, Weng Z, et al. Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin. Gastroenterology research and practice. 2017 ; 2017 : 5687496. https://doi.org/10.1155/2017/5687496
  9. Liu M, Zhang S, Gai Y, Xie M, Qi Q. Changes in the Interstitial Cells of Cajal and Immunity in Chronic Psychological Stress Rats and Therapeutic Effects of Acupuncture at the Zusanli Point (ST36). Evid Based Complement Alternat Med. 2016 ; 2016 : 1935372. https://doi.org/10.1155/2016/1935372
  10. Wang SJ, Yang HY, Wang F, Li ST. Acupoint Specificity on Colorectal Hypersensitivity Alleviated by Acupuncture and the Correlation with the Brain-Gut Axis. Neurochem Res. 2015 ; 40(6) : 1274-82. https://doi.org/10.1007/s11064-015-1587-0
  11. Al-Chaer ED, Kawasaki M, Pasricha PJ. A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology. 2000 ; 119(5) : 1276-85. https://doi.org/10.1053/gast.2000.19576
  12. Zhou EH, Liu HR, Wu HG, Shi Y, Wang XM, Yao LQ, et al. Herb-partition moxibustion relieves chronic visceral hyperalgesia and 5-HT concentration in colon mucosa of rats. Neurol Res. 2009 ; 31(7) : 734-7. https://doi.org/10.1179/174313209X382313
  13. Zhou EH, Liu HR, Wu HG, Shi Y, Wang XM, Tan LY, et al. Suspended moxibustion relieves chronic visceral hyperalgesia via serotonin pathway in the colon. Neurosci Lett. 2009 ; 451(2) : 144-7. https://doi.org/10.1016/j.neulet.2008.12.026
  14. Zhao C, Qi L, Wu L, Yi T, Wu H, Guo X, et al. Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity. Neural Regen Res. 2012 ; 7(15) : 1145-50. https://doi.org/10.3969%2Fj.issn.1673-5374.2012.15.004 https://doi.org/10.3969/j.issn.1673-5374.2012.15.004
  15. Zhou C, Zhao J, Wu L, Huang R, Shi Y, Wang X, et al. Mild moxibustion decreases the expression of prokineticin 2 and prokineticin receptor 2 in the colon and spinal cord of rats with irritable bowel syndrome. Evid Based Complement Alternat Med. 2014 ; 2014 : 807308. https://doi.org/10.1155/2014/807308
  16. Li YW, Zhao JM, Chen L, Shang HX, Wu LY, Bao CH, et al. [Effect of Electroacupuncture and Moxibustion on Visceral Pain and Expression of VR 1 and HSP 70 of "Tianshu" (ST 25) Region in Colorectal Distension-induced Visceral Hypersensitivity Rats]. Zhen Ci Yan Jiu. 2016 ; 41(4) : 291-7.
  17. Liu HR, Fang XY, Wu HG, Wu LY, Li J, Weng ZJ, et al. Effects of electroacupuncture on corticotropin-releasing hormone in rats with chronic visceral hypersensitivity. World J Gastroenterol. 2015 ; 21(23) : 7181-90. https://doi.org/10.3748/wjg.v21.i23.7181
  18. Zhao JM, Li L, Chen L, Shi Y, Li YW, Shang HX, et al. Comparison of the analgesic effects between electro-acupuncture and moxibustion with visceral hypersensitivity rats in irritable bowel syndrome. World J Gastroenterol. 2017 ; 23(16) : 2928-39. https://doi.org/10.3748/wjg.v23.i16.2928
  19. Liu S, Shi Q, Zhu Q, Zou T, Li G, Huang A, et al. $P2X_7$ receptor of rat dorsal root ganglia is involved in the effect of moxibustion on visceral hyperalgesia. Purinergic Signal. 2015 ; 11(2) : 161-9. https://doi.org/10.1007/s11302-014-9439-y
  20. Liu HR, Wang XM, Zhou EH, Shi Y, Li N, Yuan LS, et al. Acupuncture at both ST25 and ST37 improves the pain threshold of chronic visceral hypersensitivity rats. Neurochem Res. 2009 ; 34(11) : 1914-8. https://doi.org/10.1007/s11064-009-9972-1
  21. Guo X, Chen J, Lu Y, Wu L, Weng Z, Yang L, et al. Electroacupuncture at He-Mu points reduces $P2X_4$ receptor expression in visceral hypersensitivity. Neural Regen Res. 2013 ; 8(22) : 2069-77. https://doi.org/10.3969/j.issn.1673-5374.2013.22.006
  22. Weng Z, Wu L, Lu Y, Wang L, Tan L, Dong M, et al. Electroacupuncture diminishes P2X2 and P2X3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity. Neural Regen Res. 2013 ; 8(9) : 802-8. https://doi.org/10.3969/j.issn.1673-5374.2013.09.004
  23. Zhou EH, Wang XM, Ding GH, Wu HG, Qi L, Liu HR, et al. Suspended moxibustion relieves chronic visceral hyperalgesia and decreases hypothalamic corticotropin-releasing hormone levels. World J Gastroenterol. 2011 ; 17(5) : 662-5. https://doi.org/10.3748/wjg.v17.i5.662
  24. Wang LD, Zhao JM, Huang RJ, Tan LY, Hu ZH, Weng ZJ, et al. Study on the Mechanism Underlying the Regulation of the NMDA Receptor Pathway in Spinal Dorsal Horns of Visceral Hypersensitivity Rats by Moxibustion. Evid Based Complement Alternat Med. 2016 ; 2016 : 3174608. https://doi.org/10.1155/2016/3174608
  25. Tian XY, Bian ZX, Hu XG, Zhang XJ, Liu L, Zhang H. Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain Res. 2006 ; 1088(1) : 101-8. https://doi.org/10.1016/j.brainres.2006.03.014
  26. Cui KM, Li WM, Gao X, Chung K, Chung JM, Wu GC. Electro-acupuncture relieves chronic visceral hyperalgesia in rats. Neurosci Lett. 2005 ; 376(1) : 20-3. https://doi.org/10.1016/j.neulet.2004.11.018
  27. Chu D, Cheng P, Xiong H, Zhang J, Liu S, Hou X. Electroacupuncture at ST-36 relieves visceral hypersensitivity and decreases 5-HT(3) receptor level in the colon in chronic visceral hypersensitivity rats. Int J Colorectal Dis. 2011 ; 26(5) : 569-74. https://doi.org/10.1007/s00384-010-1087-2
  28. Zhao JM, Chen L, Zhou CL, Shi Y, Li YW, Shang HX, et al. Comparison of Electroacupuncture and Moxibustion for Relieving Visceral Hypersensitivity in Rats with Constipation-Predominant Irritable Bowel Syndrome. Evid Based Complement Alternat Med. 2016 ; 2016 : 9410505. https://doi.org/10.1155/2016/9410505
  29. Zhou YY, Wanner NJ, Xiao Y, Shi XZ, Jiang XH, Gu JG, et al. Electroacupuncture alleviates stress-induced visceral hypersensitivity through an opioid system in rats. World J Gastroenterol. 2012 ; 18(48) : 7201-11. https://doi.org/10.3748/wjg.v18.i48.7201
  30. Ma XP, Tan LY, Yang Y, Wu HG, Jiang B, Liu HR, et al. Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome. World J Gastroenterol. 2009 ; 15(41) : 5211-7. https://doi.org/10.3748/wjg.15.5211
  31. Wu HG, Jiang B, Zhou EH, Shi Z, Shi DR, Cui YH, et al. Regulatory mechanism of electroacupuncture in irritable bowel syndrome: preventing MC activation and decreasing SP VIP secretion. Dig Dis Sci. 2008 ; 53(6) : 1644-51. https://doi.org/10.1007/s10620-007-0062-4
  32. Zhou J, Li S, Wang Y, Foreman RD, Yin J, Zhang S, et al. Inhibitory Effects and Mechanisms of Electroacupuncture via Chronically Implanted Electrodes on Stress-Induced Gastric Hypersensitivity in Rats With Neonatal Treatment of Iodoacetamide. Neuromodulation. 2017 ; 20(8) : 767-73. https://doi.org/10.1111/ner.12602
  33. Huang R, Zhao J, Wu L, Dou C, Liu H, Weng Z, et al. Mechanisms underlying the analgesic effect of moxibustion on visceral pain in irritable bowel syndrome: a review. Evid Based Complement Alternat Med. 2014 ; 2014 : 895914. https://doi.org/10.1155/2014/895914
  34. Han JS. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci. 2003 ; 26(1) : 17-22. https://doi.org/10.1016/s0166-2236(02)00006-1