세라미스트 (Ceramist)

  • 제22권3호
  • /
  • Pages.269-280
  • /
  • 2019
  • /
  • 1226-976X(pISSN)
  • /
  • 2586-0631(eISSN)
한국세라믹학회 (The Korean Ceramic Society)
권호 표지
DOI QR코드

DOI QR Code

세라믹 LDH 나노하이브리드를 이용한 MRI 조영제의 최신 연구동향

Recent Progress in MRI Contrast Agent with Ceramic LDH Nanohybrids

  • 하성진 (경남대학교 나노신소재공학과) ;
  • 김문희 (경남대학교 나노신소재공학과) ;
  • 박대환 (경남대학교 나노신소재공학과)
  • Ha, Seongjin (Department of Nano Materials Science and Engineering, Kyungnam University) ;
  • Jin, Wenji (Department of Nano Materials Science and Engineering, Kyungnam University) ;
  • Park, Dae-Hwan (Department of Nano Materials Science and Engineering, Kyungnam University)
  • 투고 : 2019.08.29
  • 심사 : 2019.09.10
  • 발행 : 2019.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Ceramic layered double hydroxide (LDH) nanohybrids have attracted considerable interest in biomedical science due to their unique structural feature and characteristics in biological condition. Many studies on LDH nanoparticles have been reported in diagnosis applications including magnetic resonance imaging (MRI) contrast agents in order to not only provide better imaging performance through multimodal imaging strategy, but realize therapeutic function which treat cancers in one platform. This review highlights the recent progress in MRI T1 contrast agent, dual modal imaging system, and MRI-guided drug delivery systems ranging from synthetic method and characterization to evaluation in vitro and in vivo based on the ceramic LDH nanohybrids. Future research directions are also suggested for next-generation bio-imaging contrast agent.

키워드

참고문헌

  1. D. H. Park, G. Choi, and J. H. Choy, "Bio-Layered Double Hydroxides Nanohybrids for Theranostics Application," Photofunctional Layered Materials, 166 137-175 (2015). https://doi.org/10.1007/978-3-319-16991-0_4
  2. D. H. Park, J. E. Kim, J. M. Oh, Y. G. Shul, and J. H. Choy, "DNA Core@Inorganic Shell," J. Am. Chem. Soc., 132 [47] 16735-16736 (2010). https://doi.org/10.1021/ja105809e
  3. J. M. Oh, C. B. Park, and J. H. Choy, "Intracellular Drug Delivery of Layered Double Hydroxide Nanoparticles," J. Nanosci. Nanotechnol., 11 [2] 1632-1635 (2011). https://doi.org/10.1166/jnn.2011.3409
  4. L. Peng, X. Mei, J. He, J. Xu, W. Zhang, R. Liang, M. Wei, D. G. Evans, and X. Duan, "Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics," Adv. Mater., 30 [16] 1707389 (2018). https://doi.org/10.1002/adma.201707389
  5. J. M. Oh, D. H. Park, S. J. Choi, and J. H. Choy, "LDH Nanocontainers as Bio-Reservoirs and Drug Delivery Carriers," Recent Patents on Nanotechnology, 6 [3] 200-217 (2012). https://doi.org/10.2174/187221012803531538
  6. L. M. Ribeiro, A. S. Alcantara, M. Darder, P. Aranda, F. M. Araujo-Moreira, E. Ruiz-Hitzky, "Pectin-coated chitosan-LDH bionanocomposite beads as potential systems for colon-targeted drug delivery," International Journal of Pharmaceutics, 463 [1] 1-9 (2013). https://doi.org/10.1016/j.ijpharm.2013.12.035
  7. G. Varga, Z. Konya, A Kukovecz, P. Sipos, I. Palinko, "Co(II)-amino acid-CaAl-layered double hydroxide composites - construction and characterization," J. Mol. Struct., 1179 263-268 (2018)
  8. S. Y. Kim, J. M. Oh, J. S. Lee, T. J. Kim, and J. H. Choy, "Gadolinium (III) Diethylenetriamine Pentaacetic Acid/Layered Double Hydroxide Nanohybrid as Novel $T_1$-Magnetic Resonant Nanoparticles," J. Nanosci., 8 [10] 5181-5184 (2008).
  9. B. Li, Z. Gu, N. Kurniawan, W. Chen, and Z. P. Xu, "Manganese-Based Layered Double Hydroxide Nanoparticles as a T1-MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity," Adv. Mater., 29 [29] 1700373 (2017). https://doi.org/10.1002/adma.201700373
  10. J. M. Oh, S. J. Choi, G. E. Lee, J. E. Kim and J. H. Choy, "Inorganic Metal Hydroxide Nanoparticles for Targeted Cellular Uptake Through Clathrin-Mediated Endocytosis," Chem. Asain J., 4 [1] 67-73 (2009). https://doi.org/10.1002/asia.200800290
  11. H. B. Na, and T. Hyeon, "Nanostructured T1 MRI contrast agents," J Mater chem, 19 [35] 6267-6273 (2009). https://doi.org/10.1039/b902685a
  12. G. Sun, J. Feng, F. Jing, F. Pei, M. Liu, "Synthesis and evaluation of novel polysaccharide-Gd-DTPA compound s as contrast agent for MRI," J. Magn. Magn. Mater, 265 [2] 123-129 (2003). https://doi.org/10.1016/S0304-8853(03)00239-7
  13. R. M. Taylor, D. L. Huber, T. C. Monson, A. S. Ali, M. Bisoffi, L. O. Sillerud, "Multifunctional iron platinum stealth immunomicelles: targeted detection of human prostate cancer cells using both fluorescence and magnetic resonance imaging," J Nanopart Res, 13 [10] 4717-4729 (2011). https://doi.org/10.1007/s11051-011-0439-3
  14. J. M. Oh, M. Park, S. T. Kim, J. Y. Jung, Y. G. Kang, J. H. Choy, "Efficient delivery of anticancer drug MTX through MTX-LDH nanohybrid system," J. Phys. Chem. Solids., 67 [5-6] 1024-1027 (2006). https://doi.org/10.1016/j.jpcs.2006.01.033
  15. J. Y. Kim, S. J. Choi, J. M. Oh, T. E. Park, and J. H. Choy, "Anticancer Drug-Inorganic Nanohybrid and Its Cellular Interaction," J. Nanosci. Nanotechnol., 7 [11] 3700-3705 (2007). https://doi.org/10.1166/jnn.2007.061
  16. L. Wang, H. Xing, S. Zhang, Q. Ren, L. Pan, K. Zhang, W. Bu, X. Zheng, L. Zhou, W. Peng, Y. Hua , J. Shi, "A Gd-doped Mg-Al-LDH/Au nanocomposit e for CT/MR bimodal imagings and simultaneous drug delivery," Biomaterials, 34 [13] 3390-3401 (2013). https://doi.org/10.1016/j.biomaterials.2013.01.070
  17. Z. P. Xu, N. D. Kurniawan, P. F. Bartlett, and G. Q. Lu, "Enhancement of Relaxivity Rates of Gd-DTPA Complexes by Intercalation into Layered Double Hydroxide Nanoparticles," Chem. Eur. J., 13 2824-2830 (2007) https://doi.org/10.1002/chem.200600571
  18. S. J. Choi, J. M. Oh, and J. H. Choy, "Human-related application and nanotoxicology of inorganic particles: complementary aspects," J. Mater. Chem., 18 [6] 605-712 (2008). https://doi.org/10.1039/b800750k
  19. T. H. Shin, Y. S. Choi, S. J. Kim, and J. W. Cheon, "Recent advances in magnetic nanoparticle-based ulti-modal imaging," Chem. Soc. Rev., 44 [14] 4501-4516 (2015). https://doi.org/10.1039/C4CS00345D
  20. J. R. Ashton, J. L. West, and C. T. Badea, "In vivo small animal micro-CT using nanoparticle contrast agents." Front Pharmacol, 6 (2015)
  21. S. Shi, B. C. Fliss, Z. Gu, Y. Zhu, H. Hong, H. F. Valdovinos, R. Hernandez, S. Goel, H. Luo, F. Chen, T. E. Barnhart, R. J. Nickles, Z. P. Xu, & W. Gai, "Chelator-Free Labeling of Layered Double Hydroxide Nanoparticles for in Vivo PET Imaging," Sci. Rep., 5 [1] 16930 (2015). https://doi.org/10.1038/srep16930
  22. G. Hong, A. L. Antaris, and H. Dai, "Near-infrared fluorophores for biomedical imaging," Nat. Biomed. Eng., 1 [1] (2017).
  23. S. W. Chou, Y. H. Shau, P. C. Wu, Y. S. Yang, D. B. Shieh, and C. C. Chen, "In Vitro and in Vivo Studies of FePt Nanoparticles for Dual Modal CT/MRI Molecular Imaging," J. Am. Chem. Soc., 132 [38] 13270-13278 (2010). https://doi.org/10.1021/ja1035013
  24. S. Liang, Q. Zhou, M. Wang, Y. Zhu, Q. Wu, X. Yang, "Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma," Int. J. Nanomedicine., 10 2325-2333 (2015) https://doi.org/10.2147/IJN.S75174
  25. R. Chakravarty, H. F. Valdovinos, F. Chen, C. M. Lewis, P. A. Ellison, H. Luo, M. E. Meyerand, R. J. Nickles, and W. Cai, "Intrinsically Germanium-69-Labeled Iron Oxide Nanoparticles: Synthesis and In-Vivo Dual-Modality PET/MR Imaging," Adv. Mater., 26 [30] 5119-5123 (2014). https://doi.org/10.1002/adma.201401372
  26. M. Zhou, R. Zhang, M. Huang, W. Lu, S. Song, M. P. Melancon, M. Tian, D. Liang, and C. Li, "A Chelator-Free Multifunctional [$^{64}Cu$]CuS Nanoparticle Platform for Simultaneous Micro-PET/CT Imaging and Photothermal Ablation Therapy," J. Am. Chem. Soc., 132 [43] 15351-15358 (2010). https://doi.org/10.1021/ja106855m
  27. X. Su, C. Chan, J. Shi, M. K. Tsang, Y. Pan, C. Cheng, O. Gerile, M. Yang, "A graphene quantum dot@Fe3O4@SiO2 based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells," Biosens. Bioelectron., 92 489-495 (2015). https://doi.org/10.1016/j.bios.2016.10.076
  28. M. He, P. Huang, C. Zhang, H. Hu, C, Bao, G, Gao, R. He, and D. Cui, "Dual Phase-Controlled Synthesis of Uniform Lanthanide-Doped $NaGdF_4$ Upconversion Nanocrystals Via an OA/Ionic Liquid Two-Phase System for In Vivo Dual-Modality Imaging," Adv. Funct. Mater., 21 [23] 4470-4477 (2011). https://doi.org/10.1002/adfm.201101040
  29. S. Guan, R. Liang, C. Li, M. Wei, "A supramolecular material for dual-modal imaging and targeted cancer therapy," Talanta, 165 297-303 (2017). https://doi.org/10.1016/j.talanta.2016.12.068
  30. Y Zhao, F. Li, R. Zhang, D. G. Evans, and X. Duan, "Preparation of Layered Double-Hydroxide Nanomaterials with a Uniform Crystallite Size Using a New Method Involving Separate Nucleation and Aging Steps," Chem. Mater., 14 [10] 4286-4291 (2002). https://doi.org/10.1021/cm020370h
  31. L. M. Manus, R. C. Strauch, A. H. Hung, A. L. Eckermann, and T. J. Meade, "Analytical Methods for Characterizing Magnetic Resonance Probes," Anal. Chem., 84 [15] 6278-6287 (2012). https://doi.org/10.1021/ac300527z
  32. J. H. Choy, S. Y. Kwak, J. S. Park, Y. J. Jeong, and J. Portier, "Intercalative Nanohybrids of Nucleoside Monophos phates and DNA in Layered Metal Hydroxide," J. Am. Chem. Soc., 121 [6] 1399-1400 (1999). https://doi.org/10.1021/ja981823f
  33. Z. Cao, N. N. M. Adnan, G. Wang, A. R, B. Shi, R. Liu, K. Liang, L. Zhao, J. J. Gooding, C. Boyer, Z. Gu, "Conjugating Layered Double Hydroxide Nanoparticles with Phosphonic Acid Terminated Polyethylene Glycol for Improved Particle Stability," J. Colloid Interface Sci., 521 242-251 (2018). https://doi.org/10.1016/j.jcis.2018.03.006
  34. F. Barahuie, M. Z. Hussein, S. A. Gani, S. Fakuraz i, Z. Zainal, "Synthesis of protocatechuic acid-zinc/aluminium-layered double hydroxide nanocomposite as an anticancer nanodelivery system," J. Solid State Chem., 221 21-31 (2015). https://doi.org/10.1016/j.jssc.2014.09.001
  35. D. H. Park, J. Y. Cho, O. J. Kwon, C. O. Yun, and J. H. Choy, "Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation," Angew. Chem. Int. Ed., 55 4582-4586 (2016). https://doi.org/10.1002/anie.201510844
  36. J. A. Quijada, C. S. Jimenez, A. Gurinov, A. P. Centeno, I. C. Andrade, G. G. C. Arizaga, "Dysprosium-containing layered double hydroxides nanoparticles intercalated with biologically active species as an approach for theranostic systems," Mater. Sci. Eng., B, 203 7-12 (2016). https://doi.org/10.1016/j.mseb.2015.10.004
  37. H. Zuo, W. Chen, B. Li, K. Xu, H. Cooper, Z. Gu, and Z. P. Xu, "MnAl Layered Double Hydroxide Nanoparticles as a DualFunctional Platform for Magnetic Resonance Imaging and siRNA Delivery," Chem. Eur. J., 23 [57] 14299-14306 (2017). https://doi.org/10.1002/chem.201702835
  38. G. Huang, K. L. Zhang, S. Chen, S. H. Li, L. L. Wang, L. P. Wang, R. Liu, J. Gao, and H. H. Yang, "Manganese-Iron Layered Double Hydroxide: A Theranostic Nanoplatform with pH-Responsive MRI Contrast Enhancement and Drug Release," J. Mater. Chem. B, 5 [20] 3629-3633 (2017). https://doi.org/10.1039/C7TB00794A