Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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HisCoM-PAGE: software for hierarchical structural component models for pathway analysis of gene expression data

  • Mok, Lydia (Interdisciplinary Program in Bioinformatics, Seoul National University) ;
  • Park, Taesung (Interdisciplinary Program in Bioinformatics, Seoul National University)
  • Received : 2019.11.19
  • Accepted : 2019.11.22
  • Published : 2019.12.31
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Abstract

To identify pathways associated with survival phenotypes using gene expression data, we recently proposed the hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE) method. The HisCoM-PAGE software can consider hierarchical structural relationships between genes and pathways and analyze multiple pathways simultaneously. It can be applied to various types of gene expression data, such as microarray data or RNA sequencing data. We expect that the HisCoM-PAGE software will make our method more easily accessible to researchers who want to perform pathway analysis for survival times.

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References

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