Development of Extracellular Matrix (ECM) based Dermal Filler

세포외기질(ECM) 생체소재 기반 필러 개발 연구

  • Kim, Na Hyeon (Department of Biomedical Engineering, Pukyong National University) ;
  • Park, Sang-Hyug (Department of Biomedical Engineering, Pukyong National University)
  • 김나현 (부경대학교 대학원 의생명기계전기융합과정) ;
  • 박상혁 (부경대학교 대학원 의생명기계전기융합과정)
  • Received : 2019.08.14
  • Accepted : 2019.08.20
  • Published : 2019.08.31


Numerous efforts are being made to develop an ideal dermal filler that should be bio-compatibility, non-immunogenicity, long-lasting and biodegradable without a toxic secretion. Biomaterials of dermal fillers are hyaluronic acid filler, calcium filler, PMMA filler and collagen filler depending on the ingredient. Although hyaluronic acid (HA) is most widely used, it has shortages such as short shelf life and low mechanical strength compare to extracellular matrix (ECM). The cartilage ECM composed of collagen type II, proteoglycans, glycosaminoglycans (GAGs) and in a minor part with glycoproteins. In this study, we developed a cartilage ECM injectable filler capable of improving biocompatibility and longevity compared with hyaluronic acid (HA) fillers. The ECM hydrogel was cross-linked by the reaction of N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) for mechanical enhancement. Prepared ECM filler was compared with cross-linked HA by butanediol diglycidyle ether (BDDE), which is the most widely used natural polymers for dermal filler. In the results, the articular cartilage ECM hydrogel has great potential as a dermal filler to improve the biophysical and biological performance.


Supported by : 부경대학교


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