Maxillofacial Plastic and Reconstructive Surgery

  • Volume 41
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  • Pages.46.1-46.9
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  • 2019
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  • 2288-8101(pISSN)
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  • 2288-8586(eISSN)
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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Changes in oncogenic protein levels in peri-implant oral malignancy: a case report

  • Seo, Mi Hyun (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Myoung, Hoon (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Lee, Jong Ho (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Kim, Soung Min (Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Lee, Suk Keun (Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University)
  • Received : 2019.07.09
  • Accepted : 2019.10.16
  • Published : 2019.12.31
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Abstract

Background: Oral squamous cell carcinoma (OSCC) constitutes a group of tumors that exhibit heterogeneous biology, histopathology, and clinical behaviors. Case presentation: A 73-year-old male had a whitish leukoplakia-like lesion around inflamed peri-implant area (#42, #43, and #44), and this lesion had transformed to OSCC within 3 years. He underwent mass resection, selective neck dissection, and reconstructive surgery. To detect any carcinogenesis progression, we examined the removed tumor tissue as well as the patient's preoperative and postoperative sera to identify causative oncogenic proteins using immunoprecipitation high-performance liquid chromatography (IP-HPLC). Conclusions: The protein expression levels of p53, E-cadherin, β-catenin, MMP-10, HER2, NRAS, Met, HER2, and ERb were significantly lower in the serum collected on postoperative day 10 than in the preoperative serum, and if these proteins are consistently not elevated in the serum 3 months after surgery compared with the preoperative serum, these proteins can be potential oncogenic proteins. However, we also found that the serum extracted 3 months after the operation had elevated levels of oncogenic proteins compared with that of the preoperative and 10-day postoperative serum indicating the possibility of tumor recurrence. At postoperative follow-up period, ipsilateral neck metastasis and second primary lesion were found and additional surgery was performed to the patient. IP-HPLC using the patient's serum shows the possibility of oncogenic protein detection. However, follow-up IP-HPLC data is needed to find out patient-specific prognostic factors.

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References

  1. Shibuya Y, Hasegawa T, Akashi M et al (2013) Oral squamous cell carcinoma with multiple neck metastases--cases with more than ten pathologically positive lymph nodes in the unilateral side. J Oral Maxillofac Surg 71:793-797 https://doi.org/10.1016/j.joms.2012.10.001
  2. Suslu N, Hosal AS, Aslan T et al (2013) Carcinoma of the oral tongue: a case series analysis of prognostic factors and surgical outcomes. J Oral Maxillofac Surg 71:1283-1290 https://doi.org/10.1016/j.joms.2013.01.018
  3. Grimm M (2012) Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V+) is an independent prognostic factor for OSCC. Clin Transl Oncol 14:870-880 https://doi.org/10.1007/s12094-012-0867-2
  4. Liao CT, Wang HM, Ng SH et al (2006) Good tumor control and survivals of squamous cell carcinoma of buccal mucosa treated with radical surgery with or without neck dissection in Taiwan. Oral Oncol 42:800-809 https://doi.org/10.1016/j.oraloncology.2005.11.020
  5. Chen IH, Liao CT, Wang HM et al (2014) Using SCC antigen and CRP levels as prognostic biomarkers in recurrent oral cavity squamous cell carcinoma. PLoS One 9:e103265 https://doi.org/10.1371/journal.pone.0103265
  6. DE Paz D, Young CK, Chien HT et al (2019) Prognostic roles of SCC antigen, CRP and CYFRA 21-2 in oral cavity squamous cell carcinoma. Anticancer Res 39:2025-2033 https://doi.org/10.21873/anticanres.13313
  7. Kim YS (2015) Protein expression changes induced by cisplatin in an oral cancer cell line as determined by immunoprecipitation-based high performance liquid chromatography. Kor J Oral Maxillofac Pathol 39:567-582 https://doi.org/10.17779/KAOMP.2015.39.4.567
  8. Kim YS, Lee SK (2015) IP-HPLC analysis of human salivary protein complexes. Kor J Oral Maxillofac Pathol 39:615-622 https://doi.org/10.17779/KAOMP.2015.39.5.615
  9. Kim SM, Jeong D, Kim MK et al (2017) Two different protein expression profiles of oral squamous cell carcinoma analyzed by immunoprecipitation high-performance liquid chromatography. World J Surg Oncol 15:151 https://doi.org/10.1186/s12957-017-1213-5
  10. Hashimoto H, Kitagawa K, Hougaku H et al (2011) C-reactive protein is an independent predictor of the rate of increase in early carotid atherosclerosis. Circulation 104:63-67 https://doi.org/10.1161/hc2601.091705
  11. Chen HH, Chen IH, Liao CT et al (2011) Preoperative circulating Creactive protein levels predict pathological aggressiveness in oral squamous cell carcinoma: a retrospective clinical study. Clin Otolaryngol 36:147-153 https://doi.org/10.1111/j.1749-4486.2011.02274.x
  12. van der Waal I (2009) Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol 45:317-323 https://doi.org/10.1016/j.oraloncology.2008.05.016
  13. Berglundh T, Zitzmann NU, Donati M (2011) Are peri-implantitis lesions different from periodontitis lesions? J Clin Periodontol 38:188-202 https://doi.org/10.1111/j.1600-051X.2010.01672.x
  14. Kaplan I, Hirshberg A, Shlomi B et al (2015) The importance of histopathological diagnosis in the management of lesions presenting as peri-implantitis. Clin Implant Dent Relat Res 17:e126-e133 https://doi.org/10.1111/cid.12137
  15. Boudrieau RJ, McCarthy RJ, Sisson RD Jr (2005) Sarcoma of the proximal portion of the tibia in a dog 5.5 years after tibial plateau leveling osteotomy. J Am Vet Med Assoc 227:1613-1617 https://doi.org/10.2460/javma.2005.227.1613
  16. Coen N, Kadhim MA, Wright EG et al (2003) Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells. Br J Cancer 88:548-552 https://doi.org/10.1038/sj.bjc.6600758
  17. Matsumoto M, Filho HN, Ferrari R et al (2014) Genotoxicity of endosseous implants using two cellular lineages in vitro. J Oral Implantol 40:25-29 https://doi.org/10.1563/AAID-JOI-D-10-00112
  18. Kaplan I, Zeevi I, Rosenfeld E et al (2017) Clinicopathological evaluation of malignancy adjacent to dental implants. Oral Surg Oral Med Oral Pathol Oral Radiol 123:103-112 https://doi.org/10.1016/j.oooo.2016.08.023
  19. Lessing AAD, Joseph AM, Lindgren BR et al (2017) Association of oral cavity and oropharyngeal cancer biomarkers in surgical drain fluid with patient outcomes. JAMA Otolaryngol Head Neck Surg 143:670-678 https://doi.org/10.1001/jamaoto.2016.3595
  20. Agha-Hosseini F, Mirzaii-Dizgah I, Miri-Zarandi NS (2015) Unstimulated salivary p53 in patients with oral lichen planus and squamous cell carcinoma. Acta Med Iran 53:439-443
  21. Maeda M, Johnson KR, Wheelock MJ (2005) Cadherin switching: essential for behavioral but not morphological changes during and epithelium-tomesenchyme transition. J Cell Sci 118:873-887 https://doi.org/10.1242/jcs.01634
  22. Ukpo DC, Thorstad WL, Zhang Q et al (2012) Lack of association of cadherin expression and histopathologic type, metastasis, or patient outcome in oropharyngeal squamous cell carcinoma: a tissue microarray study. Head Neck Pathol 6:38-47 https://doi.org/10.1007/s12105-011-0306-7
  23. Iwai S, Yonekawa A, Harada C et al (2010) Involvement of the Wnt-${\beta}$-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol 37:1095-1103
  24. Sinevici N, O'Sullivan J (2016) Oral cancer: deregulated molecular events and their use as biomarkers. Oral Oncol 16:12-18 https://doi.org/10.1016/j.oraloncology.2016.07.013
  25. Brusevold IJ, Soland TM, Khuu C et al (2010) Nuclear and cytoplasmic expression of Met in oral squamous cell carcinoma and in an organotypic oral cancer model. Eur J Oral Sci 118:342-349 https://doi.org/10.1111/j.1600-0722.2010.00747.x
  26. Cho YA, Kim EK, Heo SJ et al (2016) Alteration status and prognostic value of MET in head and neck squamous cell carcinoma. J Cancer 7:2197-2206 https://doi.org/10.7150/jca.16686
  27. Murugan AK, Munirajan AK, Tsuchida N (2012) Ras oncogenes in oral cancer: the past 20 years. Oral Oncol 48:383-392 https://doi.org/10.1016/j.oraloncology.2011.12.006
  28. Chen Z, Yan B, van Waves C (2008) The role of the NF-kappa B transcriptome and proteome as biomarkers in human head and neck squamous cell carcinomas. Biomark Med 2:409-426 https://doi.org/10.2217/17520363.2.4.409

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