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Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women

  • Received : 2019.11.15
  • Accepted : 2019.11.26
  • Published : 2019.12.30

Abstract

Sleep is an essential physiological process, especially for proper brain function through the formation of new pathways and processing information and cognition. Therefore, when sleep is insufficient, this can result in pathophysiologic conditions. Sleep deficiency is a risk factor for various conditions, including dementia, diabetes, and obesity. Recent studies have shown that there are differences in the prevalence of sleep disorders between genders. Insomnia, the most common type of sleep disorder, has been reported to have a higher incidence in females than in males. However, sex/gender differences in other sleep disorder subtypes are not thoroughly understood. Currently, increasing evidence suggests that gender issues should be considered important when prescribing medicine. Therefore, an investigation of the gender-dependent differences in sleep disorders is required. In this review, we first describe sex/gender differences not only in the prevalence of sleep disorders by category but in the efficacy of sleep medications. In addition, we summarize sex/gender differences in the impact of sleep disorders on incident dementia. This may help understand gender-dependent pathogenesis of sleep disorders and develop therapeutic strategies in men and women.

Keywords

References

  1. Allen, R. P. and Earley, C. J. (1996) Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep 19, 205-213. https://doi.org/10.1093/sleep/19.3.205
  2. Anderson, K. N. and Shneerson, J. M. (2009) Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J. Clin. Sleep Med. 5, 235-239. https://doi.org/10.5664/jcsm.27492
  3. Arnulf, I., Neutel, D., Herlin, B., Golmard, J. L., Leu-Semenescu, S., Cochen de Cock, V. and Vidailhet, M. (2015) Sleepiness in idiopathic REM sleep behavior disorder and parkinson disease. Sleep 38, 1529-1535. https://doi.org/10.5665/sleep.5040
  4. Aston-Jones, G. and Cohen, J. D. (2005) An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci. 28, 403-450. https://doi.org/10.1146/annurev.neuro.28.061604.135709
  5. Aurora, R. N., Kristo, D. A., Bista, S. R., Rowley, J. A., Zak, R. S., Casey, K. R., Lamm, C. I., Tracy, S. L., Rosenberg, R. S.; American Academy of Sleep Medicine (2012) The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep 35, 1039-1062.
  6. Aurora, R. N., Zak, R. S., Maganti, R. K., Auerbach, S. H., Casey, K. R., Chowdhuri, S., Karippot, A., Ramar, K., Kristo, D. A., Morgenthaler, T. I.; Standards of Practice Committee; American Academy of Sleep Medicine (2010) Best practice guide for the treatment of REM sleep behavior disorder (RBD). J. Clin. Sleep Med. 6, 85-95. https://doi.org/10.5664/jcsm.27717
  7. Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S., Sadee, W., Steiner, M., Taylor, J. and Young, E. (2005) Strategies and methods for research on sex differences in brain and behavior. Endocrinology 146, 1650-1673. https://doi.org/10.1210/en.2004-1142
  8. Benbir, G. and Guilleminault, C. (2006) Pramipexole: new use for an old drug-the potential use of pramipexole in the treatment of restless legs syndrome. Neuropsychiatr. Dis. Treat. 2, 393-405. https://doi.org/10.2147/nedt.2006.2.4.393
  9. Benedict, C., Byberg, L., Cedernaes, J., Hogenkamp, P. S., Giedratis, V., Kilander, L., Lind, L., Lannfelt, L. and Schioth, H. B. (2015) Selfreported sleep disturbance is associated with Alzheimer's disease risk in men. Alzheimers Dement. 11, 1090-1097. https://doi.org/10.1016/j.jalz.2014.08.104
  10. Bennett, T., Bray, D. and Neville, M. W. (2014) Suvorexant, a dual orexin receptor antagonist for the management of insomnia. P T 39, 264-266.
  11. Berdyyeva, T., Otte, S., Aluisio, L., Ziv, Y., Burns, L. D., Dugovic, C., Yun, S., Ghosh, K. K., Schnitzer, M. J., Lovenberg, T. and Bonaventure, P. (2014) Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope. PLoS ONE 9, e112068. https://doi.org/10.1371/journal.pone.0112068
  12. Bixler, E. O., Vgontzas, A. N., Lin, H. M., Ten Have, T., Rein, J., Vela-Bueno, A. and Kales, A. (2001) Prevalence of sleep-disordered breathing in women: effects of gender. Am. J. Respir. Crit. Care Med. 163, 608-613. https://doi.org/10.1164/ajrccm.163.3.9911064
  13. Bixler, E. O., Vgontzas, A. N., Lin, H. M., Vela-Bueno, A. and Kales, A. (2002) Insomnia in central Pennsylvania. J. Psychosom. Res. 53, 589-592. https://doi.org/10.1016/S0022-3999(02)00450-6
  14. Bjurstrom, M. F. and Irwin, M. R. (2019) Perioperative pharmacological sleep-promotion and pain control: a systematic review. Pain Pract. 19, 552-569. https://doi.org/10.1111/papr.12776
  15. Bliwise, D. L. (1993) Sleep in normal aging and dementia. Sleep 16, 40-81. https://doi.org/10.1093/sleep/16.1.40
  16. Boeuf-Cazou, O., Bongue, B., Ansiau, D., Marquie, J. C. and Lapeyre-Mestre, M. (2011) Impact of long-term benzodiazepine use on cognitive functioning in young adults: the VISAT cohort. Eur. J. Clin. Pharmacol. 67, 1045-1052. https://doi.org/10.1007/s00228-011-1047-y
  17. Bokenberger, K., Strom, P., Dahl Aslan, A. K., Johansson, A. L., Gatz, M., Pedersen, N. L. and Akerstedt, T. (2017) Association between sleep characteristics and incident dementia accounting for baseline cognitive status: a prospective population-based study. J. Gerontol. A Biol. Sci. Med. Sci. 72, 134-139. https://doi.org/10.1093/gerona/glw127
  18. Bonakis, A., Howard, R. S., Ebrahim, I. O., Merritt, S. and Williams, A. (2009) REM sleep behaviour disorder (RBD) and its associations in young patients. Sleep Med. 10, 641-645. https://doi.org/10.1016/j.sleep.2008.07.008
  19. Borgen, L. A., Okerholm, R., Morrison, D. and Lai, A. (2003) The influence of gender and food on the pharmacokinetics of sodium oxybate oral solution in healthy subjects. J. Clin. Pharmacol. 43, 59-65. https://doi.org/10.1177/0091270002239707
  20. Boutrel, B. and Koob, G. F. (2004) What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep 27, 1181-1194. https://doi.org/10.1093/sleep/27.6.1181
  21. Breslau, N., Roth, T., Rosenthal, L. and Andreski, P. (1996) Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol. Psychiatry 39, 411-418. https://doi.org/10.1016/0006-3223(95)00188-3
  22. Buysse, D. J. (2013) Insomnia. JAMA 309, 706-716. https://doi.org/10.1001/jama.2013.193
  23. Chait, L. D. (1993) Factors influencing the reinforcing and subjective effects of d-amphetamine in humans. Behav. Pharmacol. 4, 191-199. https://doi.org/10.1097/00008877-199306000-00001
  24. Chait, L. D. (1994) Factors influencing the reinforcing and subjective effects of ephedrine in humans. Psychopharmacology (Berl.) 113, 381-387. https://doi.org/10.1007/BF02245213
  25. Chang, W. P., Liu, M. E., Chang, W. C., Yang, A. C., Ku, Y. C., Pai, J. T., Huang, H. L. and Tsai, S. J. (2013) Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan. PLoS ONE 8, e78655. https://doi.org/10.1371/journal.pone.0078655
  26. Chaudhury, D., Wang, L. M. and Colwell, C. S. (2005) Circadian regulation of hippocampal long-term potentiation. J. Biol. Rhythms 20, 225-236. https://doi.org/10.1177/0748730405276352
  27. Chen, L., Bell, J. S., Visvanathan, R., Hilmer, S. N., Emery, T., Robson, L., Hughes, J. M. and Tan, E. C. (2016) The association between benzodiazepine use and sleep quality in residential aged care facilities: a cross-sectional study. BMC Geriatr. 16, 196. https://doi.org/10.1186/s12877-016-0363-6
  28. Chen, P. L., Lee, W. J., Sun, W. Z., Oyang, Y. J. and Fuh, J. L. (2012) Risk of dementia in patients with insomnia and long-term use of hypnotics: a population-based retrospective cohort study. PLoS ONE 7, e49113. https://doi.org/10.1371/journal.pone.0049113
  29. Cheng, H. T., Lin, F. J., Erickson, S. R., Hong, J. L. and Wu, C. H. (2017) The association between the use of zolpidem and the risk of Alzheimer's disease among older people. J. Am. Geriatr. Soc. 65, 2488-2495. https://doi.org/10.1111/jgs.15018
  30. Cordovilla-Guardia, S., Lardelli-Claret, P., Vilar-Lopez, R., Lopez-Espuela, F., Guerrero-Lopez, F. and Fernandez-Mondejar, E. (2019) The effect of central nervous system depressant, stimulant and hallucinogenic drugs on injury severity in patients admitted for trauma. Gac. Sanit. 33, 4-9. https://doi.org/10.1016/j.gaceta.2017.06.006
  31. Cricco, M., Simonsick, E. M. and Foley, D. J. (2001) The impact of insomnia on cognitive functioning in older adults. J. Am. Geriatr. Soc. 49, 1185-1189. https://doi.org/10.1046/j.1532-5415.2001.49235.x
  32. Crowley, K. (2011) Sleep and sleep disorders in older adults. Neuropsychol. Rev. 21, 41-53. https://doi.org/10.1007/s11065-010-9154-6
  33. Culebras, A. and Anwar, S. (2018) Sleep apnea is a risk factor for stroke and vascular dementia. Curr. Neurol. Neurosci. Rep. 18, 53. https://doi.org/10.1007/s11910-018-0855-1
  34. Czeisler, C. A., Dumont, M., Duffy, J. F., Steinberg, J. D., Richardson, G. S., Brown, E. N., Sanchez, R., Rios, C. D. and Ronda, J. M. (1992) Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet 340, 933-936. https://doi.org/10.1016/0140-6736(92)92817-Y
  35. Dagan, Y. (2002) Circadian rhythm sleep disorders (CRSD). Sleep Med. Rev. 6, 45-55. https://doi.org/10.1053/smrv.2001.0190
  36. Dauvilliers, Y. and Buguet, A. (2005) Hypersomnia. Dialogues Clin. Neurosci. 7, 347-356. https://doi.org/10.31887/DCNS.2005.7.4/ydauvilliers
  37. de Almondes, K. M., Costa, M. V., Malloy-Diniz, L. F. and Diniz, B. S. (2016) Insomnia and risk of dementia in older adults: systematic review and meta-analysis. J. Psychiatr. Res. 77, 109-115. https://doi.org/10.1016/j.jpsychires.2016.02.021
  38. de Gage, S. B., Begaud, B., Bazin, F., Verdoux, H., Dartigues, J. F., Peres, K., Kurth, T. and Pariente, A. (2012) Benzodiazepine use and risk of dementia: prospective population based study. BMJ 345, e6231. https://doi.org/10.1136/bmj.e6231
  39. Diekelmann, S. and Born, J. (2010) The memory function of sleep. Nat. Rev. Neurosci. 11, 114-126. https://doi.org/10.1038/nrn2762
  40. Duran, J., Esnaola, S., Rubio, R. and Iztueta, A. (2001) Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am. J. Respir. Crit. Care Med. 163, 685-689. https://doi.org/10.1164/ajrccm.163.3.2005065
  41. Earley, C. J. and Silber, M. H. (2010) Restless legs syndrome: understanding its consequences and the need for better treatment. Sleep Med. 11, 807-815. https://doi.org/10.1016/j.sleep.2010.07.007
  42. Elwood, P. C., Bayer, A. J., Fish, M., Pickering, J., Mitchell, C. and Gallacher, J. E. (2011) Sleep disturbance and daytime sleepiness predict vascular dementia. J. Epidemiol. Community Health 65, 820-824. https://doi.org/10.1136/jech.2009.100503
  43. Erman, M., Seiden, D., Zammit, G., Sainati, S. and Zhang, J. (2006) An efficacy, safety, and dose-response study of Ramelteon in patients with chronic primary insomnia. Sleep Med. 7, 17-24. https://doi.org/10.1016/j.sleep.2005.09.004
  44. Evans, S. M., Haney, M., Fischman, M. W. and Foltin, R. W. (1999) Limited sex differences in response to “binge” smoked cocaine use in humans. Neuropsychopharmacology 21, 445-454. https://doi.org/10.1016/S0893-133X(98)00120-1
  45. Fantini, M. L., Postuma, R. B., Montplaisir, J. and Ferini-Strambi, L. (2006) Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder. Brain Res. Bull. 70, 386-390. https://doi.org/10.1016/j.brainresbull.2006.07.008
  46. Fatani, A., Al-Rouqi, K., Al Towairky, J., Ahmed, A. E., Al-Jahdali, S., Ali, Y., Al-Shimemeri, A., Al-Harbi, A., Baharoon, S., Khan, M. and Al-Jahdali, H. (2015) Effect of age and gender in the prevalence of excessive daytime sleepiness among a sample of the Saudi population. J. Epidemiol. Glob. Health 5, S59-S66. https://doi.org/10.1016/j.jegh.2015.05.005
  47. Fleetham, J. A. and Fleming, J. A. (2014) Parasomnias. CMAJ 186, E273-E280. https://doi.org/10.1503/cmaj.120808
  48. Foley, D., Monjan, A., Masaki, K., Ross, W., Havlik, R., White, L. and Launer, L. (2001) Daytime sleepiness is associated with 3-year incident dementia and cognitive decline in older Japanese-American men. J. Am. Geriatr. Soc. 49, 1628-1632. https://doi.org/10.1111/j.1532-5415.2001.49271.x
  49. Foley, D. J., Monjan, A. A., Brown, S. L., Simonsick, E. M., Wallace, R. B. and Blazer, D. G. (1995) Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep 18, 425-432. https://doi.org/10.1093/sleep/18.6.425
  50. Gabbay, F. H. (2003) Variations in affect following amphetamine and placebo: markers of stimulant drug preference. Exp. Clin. Psychopharmacol. 11, 91-101. https://doi.org/10.1037/1064-1297.11.1.91
  51. Gehrman, P., Marler, M., Martin, J. L., Shochat, T., Corey-Bloom, J. and Ancoli-Israel, S. (2004) The timing of activity rhythms in patients with dementia is related to survival. J. Gerontol. A Biol. Sci. Med. Sci. 59, 1050-1055. https://doi.org/10.1093/gerona/59.10.M1050
  52. George, A. J. (2000) Central nervous system stimulants. Baillieres Best Pract. Res. Clin. Endocrinol. Metab. 14, 79-88. https://doi.org/10.1053/beem.2000.0055
  53. Gjerstad, M. D., Alves, G., Wentzel-Larsen, T., Aarsland, D. and Larsen, J. P. (2006) Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology 67, 853-858. https://doi.org/10.1212/01.wnl.0000233980.25978.9d
  54. Golden, L. C. and Voskuhl, R. (2017) The importance of studying sex differences in disease: the example of multiple sclerosis. J. Neurosci. Res. 95, 633-643. https://doi.org/10.1002/jnr.23955
  55. Green, R. C., Cupples, L. A., Kurz, A., Auerbach, S., Go, R., Sadovnick, D., Duara, R., Kukull, W. A., Chui, H., Edeki, T., Griffith, P. A., Friedland, R. P., Bachman, D. and Farrer, L. (2003) Depression as a risk factor for Alzheimer disease: the MIRAGE Study. Arch. Neurol. 60, 753-759. https://doi.org/10.1001/archneur.60.5.753
  56. Greenblatt, D. J., Harmatz, J. S. and Karim, A. (2007) Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2. J. Clin. Pharmacol. 47, 485-496. https://doi.org/10.1177/0091270006298602
  57. Greenblatt, D. J., Harmatz, J. S., von Moltke, L. L., Wright, C. E. and Shader, R. I. (2004) Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate. Clin. Pharmacol. Ther. 76, 467-479. https://doi.org/10.1016/j.clpt.2004.07.009
  58. Gu, D., Sautter, J., Pipkin, R. and Zeng, Y. (2010) Sociodemographic and health correlates of sleep quality and duration among very old Chinese. Sleep 33, 601-610.
  59. Guarnieri, B. (2019) Sleep disorders and cognitive alterations in women. Maturitas 126, 25-27. https://doi.org/10.1016/j.maturitas.2019.04.214
  60. Guo, T., Mao, G., Zhao, L., Xia, D. and Yang, L. (2014) Comparative pharmacokinetics of zolpidem tartrate in five ethnic populations of China. Acta Pharm. Sin. B 4, 146-150. https://doi.org/10.1016/j.apsb.2014.02.001
  61. Guo, T., Zhao, L. S. and Xia, D. Y. (2010) Pharmacokinetic study of modafinil in relation to gender and ethnicity in healthy young Chinese volunteers. J. Pharm. Pharm. Sci. 13, 443-449. https://doi.org/10.18433/J3FK5R
  62. Hara, C., Lopes Rocha, F. and Lima-Costa, M. F. (2004) Prevalence of excessive daytime sleepiness and associated factors in a Brazilian community: the Bambui study. Sleep Med. 5, 31-36. https://doi.org/10.1016/j.sleep.2003.09.009
  63. Hayley, A. C., Williams, L. J., Kennedy, G. A., Berk, M., Brennan, S. L. and Pasco, J. A. (2014) Prevalence of excessive daytime sleepiness in a sample of the Australian adult population. Sleep Med. 15, 348-354. https://doi.org/10.1016/j.sleep.2013.11.783
  64. Heaney, R. P. (2001) Factors influencing the measurement of bioavailability, taking calcium as a model. J. Nutr. 131, 1344S-1348S. https://doi.org/10.1093/jn/131.4.1344S
  65. Herring, W. J., Connor, K. M., Snyder, E., Snavely, D. B., Zhang, Y., Hutzelmann, J., Matzura-Wolfe, D., Benca, R. M., Krystal, A. D., Walsh, J. K., Lines, C., Roth, T. and Michelson, D. (2017) Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data. Psychopharmacology (Berl.) 234, 1703-1711. https://doi.org/10.1007/s00213-017-4573-1
  66. Hobson, D. E., Lang, A. E., Martin, W. R., Razmy, A., Rivest, J. and Fleming, J. (2002) Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders Group. JAMA 287, 455-463. https://doi.org/10.1001/jama.287.4.455
  67. Hofman, M. A. and Swaab, D. F. (2006) Living by the clock: the circadian pacemaker in older people. Ageing Res. Rev. 5, 33-51. https://doi.org/10.1016/j.arr.2005.07.001
  68. Howell, M. J. (2012) Parasomnias: an updated review. Neurotherapeutics 9, 753-775. https://doi.org/10.1007/s13311-012-0143-8
  69. Hung, C. M., Li, Y. C., Chen, H. J., Lu, K., Liang, C. L., Liliang, P. C., Tsai, Y. D. and Wang, K. W. (2018) Risk of dementia in patients with primary insomnia: a nationwide population-based case-control study. BMC Psychiatry 18, 38. https://doi.org/10.1186/s12888-018-1623-0
  70. Hutchinson, M. A., Smith, P. F. and Darlington, C. L. (1996) The behavioural and neuronal effects of the chronic administration of benzodiazepine anxiolytic and hypnotic drugs. Prog. Neurobiol. 49, 73-97. https://doi.org/10.1016/0301-0082(96)00011-1
  71. Ihara, M., Tomimoto, H., Ishizu, K., Mukai, T., Yoshida, H., Sawamoto, N., Inoue, M., Doi, T., Hashikawa, K., Konishi, J., Shibasaki, H. and Fukuyama, H. (2004) Decrease in cortical benzodiazepine receptors in symptomatic patients with leukoaraiosis: a positron emission tomography study. Stroke 35, 942-947. https://doi.org/10.1161/01.STR.0000122624.32167.e0
  72. Innes, K. E., Flack, K. L., Selfe, T. K., Kandati, S. and Agarwal, P. (2013) Restless legs syndrome in an appalachian primary care population: prevalence, demographic and lifestyle correlates, and burden. J. Clin. Sleep Med. 9, 1065-1075. https://doi.org/10.5664/jcsm.3084
  73. Ip, M. S., Lam, B., Ng, M. M., Lam, W. K., Tsang, K. W. and Lam, K. S. (2002) Obstructive sleep apnea is independently associated with insulin resistance. Am. J. Respir. Crit. Care Med. 165, 670-676. https://doi.org/10.1164/ajrccm.165.5.2103001
  74. Iranzo, A., Santamaria, J. and Tolosa, E. (2016) Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions. Lancet Neurol. 15, 405-419. https://doi.org/10.1016/S1474-4422(16)00057-0
  75. Islam, M. M., Iqbal, U., Walther, B., Atique, S., Dubey, N. K., Nguyen, P. A., Poly, T. N., Masud, J. H., Li, Y. J. and Shabbir, S. A. (2016) Benzodiazepine use and risk of dementia in the elderly population: a systematic review and meta-analysis. Neuroepidemiology 47, 181-191. https://doi.org/10.1159/000454881
  76. Jacobs, M. L., Dauvilliers, Y., St Louis, E. K., McCarter, S. J., Romenets, S. R., Pelletier, A., Cherif, M., Gagnon, J. F. and Postuma, R. B. (2016) Risk factor profile in Parkinson's disease subtype with REM sleep behavior disorder. J. Parkinsons Dis. 6, 231-237. https://doi.org/10.3233/JPD-150725
  77. Jaussent, I., Bouyer, J., Ancelin, M. L., Berr, C., Foubert-Samier, A., Ritchie, K., Ohayon, M. M., Besset, A. and Dauvilliers, Y. (2012) Excessive sleepiness is predictive of cognitive decline in the elderly. Sleep 35, 1201-1207. https://doi.org/10.5665/sleep.2070
  78. Joo, S., Baik, I., Yi, H., Jung, K., Kim, J. and Shin, C. (2009) Prevalence of excessive daytime sleepiness and associated factors in the adult population of Korea. Sleep Med. 10, 182-188. https://doi.org/10.1016/j.sleep.2008.03.017
  79. Joo, S., Shin, C., Kim, J., Yi, H., Ahn, Y., Park, M., Kim, J. and Lee, S. (2005) Prevalence and correlates of excessive daytime sleepiness in high school students in Korea. Psychiatry Clin. Neurosci. 59, 433-440. https://doi.org/10.1111/j.1440-1819.2005.01396.x
  80. Jordan, A. S., McSharry, D. G. and Malhotra, A. (2014) Adult obstructive sleep apnoea. Lancet 383, 736-747. https://doi.org/10.1016/S0140-6736(13)60734-5
  81. Ju, Y. E., Larson-Prior, L. and Duntley, S. (2011) Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. Sleep Med. 12, 278-283. https://doi.org/10.1016/j.sleep.2010.07.022
  82. Kang, J. E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S. and Holtzman, D. M. (2009) Amyloidbeta dynamics are regulated by orexin and the sleep-wake cycle. Science 326, 1005-1007. https://doi.org/10.1126/science.1180962
  83. Kazaglis, L. and Bornemann, M. A. C. (2016) Classification of parasomnias. Curr. Sleep Medicine Rep. 2, 45-52. https://doi.org/10.1007/s40675-016-0039-y
  84. Keitt, S. K., Fagan, T. F. and Marts, S. A. (2004) Understanding sex differences in environmental health: a thought leaders' roundtable. Environ. Health Perspect. 112, 604-609. https://doi.org/10.1289/ehp.6714
  85. Khan, Z. and Trotti, L. M. (2015) Central disorders of hypersomnolence: focus on the narcolepsies and idiopathic hypersomnia. Chest 148, 262-273. https://doi.org/10.1378/chest.14-1304
  86. Kiley, J. P., Twery, M. J. and Gibbons, G. H. (2019) The National Center on Sleep Disorders Research-progress and promise. Sleep 42, zsz105. https://doi.org/10.1093/sleep/zsz105
  87. Kim, H. I., Lim, H. and Moon, A. (2018) Sex differences in cancer: epidemiology, genetics and therapy. Biomol. Ther. (Seoul) 26, 335-342. https://doi.org/10.4062/biomolther.2018.103
  88. Kim, H. M., Gerlach, L. B., Van, T., Yosef, M., Conroy, D. A. and Zivin, K. (2019) Predictors of long-term and high-dose use of zolpidem in Veterans. J. Clin. Psychiatry 80, 18m12149.
  89. Kim, J. M., Stewart, R., Kim, S. W., Yang, S. J., Shin, I. S. and Yoon, J. S. (2009) Insomnia, depression, and physical disorders in late life: a 2-year longitudinal community study in Koreans. Sleep 32, 1221-1228. https://doi.org/10.1093/sleep/32.9.1221
  90. Krueger, J. M., Frank, M. G., Wisor, J. P. and Roy, S. (2016) Sleep function: toward elucidating an enigma. Sleep Med. Rev. 28, 46-54. https://doi.org/10.1016/j.smrv.2015.08.005
  91. Kushida, C. A., Littner, M. R., Hirshkowitz, M., Morgenthaler, T. I., Alessi, C. A., Bailey, D., Boehlecke, B., Brown, T. M., Coleman, J., Jr., Friedman, L., Kapen, S., Kapur, V. K., Kramer, M., Lee-Chiong, T., Owens, J., Pancer, J. P., Swick, T. J. and Wise, M. S.; American Academy of Sleep Medicine (2006) Practice parameters for the use of continuous and bilevel positive airway pressure devices to treat adult patients with sleep-related breathing disorders. Sleep 29, 375-380. https://doi.org/10.1093/sleep/29.3.375
  92. Lanctot, K. L., Herrmann, N., Mazzotta, P., Khan, L. R. and Ingber, N. (2004) GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia. Can. J. Psychiatry 49, 439-453. https://doi.org/10.1177/070674370404900705
  93. Lee-Iannotti, J. K. and Parish, J. M. (2016) Suvorexant: a promising, novel treatment for insomnia. Neuropsychiatr Dis. Treat. 12, 491-495.
  94. Lee, J., Jung, S. J., Choi, J. W., Shin, A. and Lee, Y. J. (2018) Use of sedative-hypnotics and the risk of Alzheimer’s dementia: a retrospective cohort study. PLoS ONE 13, e0204413. https://doi.org/10.1371/journal.pone.0204413
  95. Leufkens, T. R. and Vermeeren, A. (2014) Zopiclone's residual effects on actual driving performance in a standardized test: a pooled analysis of age and sex effects in 4 placebo-controlled studies. Clin. Ther. 36, 141-150. https://doi.org/10.1016/j.clinthera.2013.11.005
  96. Lin, C. C., Chou, C. H., Fan, Y. M., Yin, J. H., Chung, C. H., Chien, W. C., Sung, Y. F., Tsai, C. K., Lin, G. Y., Lin, Y. K. and Lee, J. T. (2015) Increased risk of dementia among sleep-related movement disorders: a population-based longitudinal study in Taiwan. Medicine (Baltimore) 94, e2331. https://doi.org/10.1097/MD.0000000000002331
  97. Lopes Da Silva, F. H. and Storm Van Leeuwen, W. (1977) The cortical source of the alpha rhythm. Neurosci. Lett. 6, 237-241. https://doi.org/10.1016/0304-3940(77)90024-6
  98. Lumeng, J. C. and Chervin, R. D. (2008) Epidemiology of pediatric obstructive sleep apnea. Proc. Am. Thorac. Soc. 5, 242-252. https://doi.org/10.1513/pats.200708-135MG
  99. Macey, P. M., Haris, N., Kumar, R., Thomas, M. A., Woo, M. A. and Harper, R. M. (2018) Obstructive sleep apnea and cortical thickness in females and males. PLoS ONE 13, e0193854. https://doi.org/10.1371/journal.pone.0193854
  100. Mahlknecht, P., Iranzo, A., Hogl, B., Frauscher, B., Muller, C., Santamaria, J., Tolosa, E., Serradell, M., Mitterling, T., Gschliesser, V., Goebel, G., Brugger, F., Scherfler, C., Poewe, W. and Seppi, K.; Sleep Innsbruck Barcelona Group (2015) Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD. Neurology 84, 654-658. https://doi.org/10.1212/WNL.0000000000001265
  101. Mannucci, C., Pichini, S., Spagnolo, E. V., Calapai, F., Gangemi, S., Navarra, M. and Calapai, G. (2018) Sodium oxybate therapy for alcohol withdrawal syndrome and keeping of alcohol abstinence. Curr. Drug Metab. 19, 1056-1064. https://doi.org/10.2174/1389200219666171207122227
  102. Marion, M. H., Qurashi, M., Marshall, G. and Foster, O. (2008) Is REM sleep behaviour disorder (RBD) a risk factor of dementia in idiopathic Parkinson's disease? J. Neurol. 255, 192-196. https://doi.org/10.1007/s00415-008-0629-9
  103. Martinelli, P., Contin, M., Scaglione, C., Riva, R., Albani, F. and Baruzzi, A. (2003) Levodopa pharmacokinetics and dyskinesias: are there sex-related differences? Neurol. Sci. 24, 192-193. https://doi.org/10.1007/s10072-003-0125-z
  104. Molano, J., Boeve, B., Ferman, T., Smith, G., Parisi, J., Dickson, D., Knopman, D., Graff-Radford, N., Geda, Y., Lucas, J., Kantarci, K., Shiung, M., Jack, C., Silber, M., Pankratz, V. S. and Petersen, R. (2010) Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study. Brain 133, 540-556. https://doi.org/10.1093/brain/awp280
  105. Moreira, F. A., Jupp, B., Belin, D. and Dalley, J. W. (2015) Endocannabinoids and striatal function: implications for addiction-related behaviours. Behav. Pharmacol. 26, 59-72. https://doi.org/10.1097/FBP.0000000000000109
  106. Morgenthaler, T. I., Kapur, V. K., Brown, T., Swick, T. J., Alessi, C., Aurora, R. N., Boehlecke, B., Chesson, A. L., Jr., Friedman, L., Maganti, R., Owens, J., Pancer, J. and Zak, R.; Standards of Practice Committee of the American Academy of Sleep Medicine (2007) Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep 30, 1705-1711. https://doi.org/10.1093/sleep/30.12.1705
  107. Morphy, H., Dunn, K. M., Lewis, M., Boardman, H. F. and Croft, P. R. (2007) Epidemiology of insomnia: a longitudinal study in a UK population. Sleep 30, 274-280.
  108. Neubauer, D. N. (2008) A review of ramelteon in the treatment of sleep disorders. Neuropsychiatr. Dis. Treat. 4, 69-79. https://doi.org/10.2147/NDT.S483
  109. Nomura, T., Inoue, Y., Kagimura, T. and Nakashima, K. (2013) Clinical significance of REM sleep behavior disorder in Parkinson's disease. Sleep Med. 14, 131-135. https://doi.org/10.1016/j.sleep.2012.10.011
  110. Oginska, H., Pokorski, J. and Oginski, A. (1993) Gender, ageing, and shiftwork intolerance. Ergonomics 36, 161-168. https://doi.org/10.1080/00140139308967868
  111. Ohayon, M. M., Lemoine, P., Arnaud-Briant, V. and Dreyfus, M. (2002) Prevalence and consequences of sleep disorders in a shift worker population. J. Psychosom. Res. 53, 577-583. https://doi.org/10.1016/S0022-3999(02)00438-5
  112. Ohayon, M. M., O'Hara, R. and Vitiello, M. V. (2012) Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med. Rev. 16, 283-295. https://doi.org/10.1016/j.smrv.2011.05.002
  113. Ohayon, M. M. and Roth, T. (2002) Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J. Psychosom. Res. 53, 547-554. https://doi.org/10.1016/S0022-3999(02)00443-9
  114. Paine, S. J., Fink, J., Gander, P. H. and Warman, G. R. (2014) Identifying advanced and delayed sleep phase disorders in the general population: a national survey of New Zealand adults. Chronobiol. Int. 31, 627-636. https://doi.org/10.3109/07420528.2014.885036
  115. Pakes, G. E., Brogden, R. N., Heel, R. C., Speight, T. M. and Avery, G. S. (1981) Triazolam: a review of its pharmacological properties and therapeutic efficacy in patients with insomnia. Drugs 22, 81-110. https://doi.org/10.2165/00003495-198122020-00001
  116. Pallesen, S., Nordhus, I. H., Omvik, S., Sivertsen, B., Tell, G. S. and Bjorvatn, B. (2007) Prevalence and risk factors of subjective sleepiness in the general adult population. Sleep 30, 619-624. https://doi.org/10.1093/sleep/30.5.619
  117. Pandi-Perumal, S. R., Trakht, I., Srinivasan, V., Spence, D. W., Maestroni, G. J., Zisapel, N. and Cardinali, D. P. (2008) Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog. Neurobiol. 85, 335-353. https://doi.org/10.1016/j.pneurobio.2008.04.001
  118. Pase, M. P., Himali, J. J., Grima, N. A., Beiser, A. S., Satizabal, C. L., Aparicio, H. J., Thomas, R. J., Gottlieb, D. J., Auerbach, S. H. and Seshadri, S. (2017) Sleep architecture and the risk of incident dementia in the community. Neurology 89, 1244-1250. https://doi.org/10.1212/WNL.0000000000004373
  119. Pat McAndrews, M., Weiss, R. T., Sandor, P., Taylor, A., Carlen, P. L. and Shapiro, C. M. (2003) Cognitive effects of long-term benzodiazepine use in older adults. Hum. Psychopharmacol. 18, 51-57. https://doi.org/10.1002/hup.453
  120. Paterniti, S., Dufouil, C., Bisserbe, J. C. and Alperovitch, A. (1999) Anxiety, depression, psychotropic drug use and cognitive impairment. Psychol. Med. 29, 421-428. https://doi.org/10.1017/S0033291798008010
  121. Patil, S. P., Ayappa, I. A., Caples, S. M., Kimoff, R. J., Patel, S. R. and Harrod, C. G. (2019) Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine clinical practice guideline. J. Clin. Sleep Med. 15, 335-343. https://doi.org/10.5664/jcsm.7640
  122. Paudel, M. L., Taylor, B. C., Ancoli-Israel, S., Blackwell, T., Stone, K. L., Tranah, G., Redline, S., Cummings, S. R. and Ensrud, K. E.; Osteoporotic Fractures in Men (MrOS) Study (2010) Rest/activity rhythms and mortality rates in older men: MrOS Sleep Study. Chronobiol. Int. 27, 363-377. https://doi.org/10.3109/07420520903419157
  123. Peppard, P. E., Young, T., Barnet, J. H., Palta, M., Hagen, E. W. and Hla, K. M. (2013) Increased prevalence of sleep-disordered breathing in adults. Am. J. Epidemiol. 177, 1006-1014. https://doi.org/10.1093/aje/kws342
  124. Phillips, B. and Mannino, D. (2005) Correlates of sleep complaints in adults: the ARIC study. J. Clin. Sleep Med. 1, 277-283. https://doi.org/10.5664/jcsm.26344
  125. Pigeon, W. R. and Yurcheshen, M. (2009) Behavioral sleep medicine interventions for Restless Legs Syndrome and Periodic Limb Movement Disorder. Sleep Med. Clin. 4, 487-494. https://doi.org/10.1016/j.jsmc.2009.07.008
  126. Postuma, R. B., Adler, C. H., Dugger, B. N., Hentz, J. G., Shill, H. A., Driver-Dunckley, E., Sabbagh, M. N., Jacobson, S. A., Belden, C. M., Sue, L. I., Serrano, G. and Beach, T. G. (2015a) REM sleep behavior disorder and neuropathology in Parkinson's disease. Mov. Disord. 30, 1413-1417. https://doi.org/10.1002/mds.26347
  127. Postuma, R. B., Gagnon, J. F., Bertrand, J. A., Genier Marchand, D. and Montplaisir, J. Y. (2015b) Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials. Neurology 84, 1104-1113. https://doi.org/10.1212/WNL.0000000000001364
  128. Postuma, R. B., Montplaisir, J., Lanfranchi, P., Blais, H., Rompre, S., Colombo, R. and Gagnon, J. F. (2011) Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. Mov. Disord. 26, 1529-1533. https://doi.org/10.1002/mds.23677
  129. Punjabi, N. M., Shahar, E., Redline, S., Gottlieb, D. J., Givelber, R. and Resnick, H. E.; Sleep Heart Health Study Investigators (2004) Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am. J. Epidemiol. 160, 521-530. https://doi.org/10.1093/aje/kwh261
  130. Rangel-Barajas, C., Coronel, I. and Floran, B. (2015) Dopamine receptors and neurodegeneration. Aging Dis. 6, 349-368. https://doi.org/10.14336/AD.2015.0330
  131. Rezvani, M., Zamani, B. and Fereshtehnejad, S. M. (2013) Factors affecting the efficacy of pramipexole in patients with restless legs syndrome. Acta Med. Iran. 51, 377-385.
  132. Rhyne, D. N. and Anderson, S. L. (2015) Suvorexant in insomnia: efficacy, safety and place in therapy. Ther. Adv. Drug Saf. 6, 189-195. https://doi.org/10.1177/2042098615595359
  133. Rissman, R. A., De Blas, A. L. and Armstrong, D. M. (2007) GABA(A) receptors in aging and Alzheimer's disease. J. Neurochem. 103, 1285-1292. https://doi.org/10.1111/j.1471-4159.2007.04832.x
  134. Roman, G. C. (1987) Senile dementia of the Binswanger type. A vascular form of dementia in the elderly. JAMA 258, 1782-1788. https://doi.org/10.1001/jama.1987.03400130096040
  135. Romeijn, N., Raymann, R. J., Most, E., Te Lindert, B., Van Der Meijden, W. P., Fronczek, R., Gomez-Herrero, G. and Van Someren, E. J. (2012) Sleep, vigilance, and thermosensitivity. Pflugers Arch. 463, 169-176. https://doi.org/10.1007/s00424-011-1042-2
  136. Romenets, S. R., Gagnon, J. F., Latreille, V., Panniset, M., Chouinard, S., Montplaisir, J. and Postuma, R. B. (2012) Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease. Mov. Disord. 27, 996-1003. https://doi.org/10.1002/mds.25086
  137. Saias, T. and Gallarda, T. (2008) Aggressive reactions under benzodiazepines: a review of the literature. Encephale 34, 330-336. https://doi.org/10.1016/j.encep.2007.05.005
  138. Sack, R. L., Auckley, D., Auger, R. R., Carskadon, M. A., Wright, K. P., Jr., Vitiello, M. V. and Zhdanova, I. V.; American Academy of Sleep Medicine (2007) Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review. Sleep 30, 1460-1483. https://doi.org/10.1093/sleep/30.11.1460
  139. Sancar, F., Ericksen, S. S., Kucken, A. M., Teissere, J. A. and Czajkowski, C. (2007) Structural determinants for high-affinity zolpidem binding to GABA-A receptors. Mol. Pharmacol. 71, 38-46. https://doi.org/10.1124/mol.106.029595
  140. Sateia, M. J. (2014) International classification of sleep disorders-third edition: highlights and modifications. Chest 146, 1387-1394. https://doi.org/10.1378/chest.14-0970
  141. Sateia, M. J., Buysse, D. J., Krystal, A. D., Neubauer, D. N. and Heald, J. L. (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline. J. Clin. Sleep Med. 13, 307-349. https://doi.org/10.5664/jcsm.6470
  142. Satlin, A., Volicer, L., Stopa, E. G. and Harper, D. (1995) Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease. Neurobiol. Aging 16, 765-771. https://doi.org/10.1016/0197-4580(95)00059-N
  143. Schenck, C. H., Bundlie, S. R. and Mahowald, M. W. (1996) Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 46, 388-393. https://doi.org/10.1212/WNL.46.2.388
  144. Sharma, M. K., Kainth, S., Kumar, S., Bhardwaj, A., Agarwal, H. K., Maiwall, R., Jamwal, K. D., Shasthry, S. M., Jindal, A., Choudhary, A., Anand, L., Dhamija, R. M., Kumar, G., Sharma, B. C. and Sarin, S. K. (2019) Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: a randomized, placebo-controlled trial. Clin. Mol. Hepatol. 25, 199-209. https://doi.org/10.3350/cmh.2018.0084
  145. Shi, L., Chen, S. J., Ma, M. Y., Bao, Y. P., Han, Y., Wang, Y. M., Shi, J., Vitiello, M. V. and Lu, L. (2018) Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Med. Rev. 40, 4-16. https://doi.org/10.1016/j.smrv.2017.06.010
  146. Shih, H. I., Lin, C. C., Tu, Y. F., Chang, C. M., Hsu, H. C., Chi, C. H. and Kao, C. H. (2015) An increased risk of reversible dementia may occur after zolpidem derivative use in the elderly population: a population-based case-control study. Medicine (Baltimore) 94, e809. https://doi.org/10.1097/MD.0000000000000809
  147. Shimohama, S., Taniguchi, T., Fujiwara, M. and Kameyama, M. (1988) Changes in benzodiazepine receptors in Alzheimer-type dementia. Ann. Neurol. 23, 404-406. https://doi.org/10.1002/ana.410230419
  148. Silber, M. H. (2013) Sleep-related movement disorders. Continuum (Minneap. Minn.) 19, 170-184. https://doi.org/10.1212/01.CON.0000427207.13553.68
  149. Silvia, R., Mor, M., Bedini, A., Spadoni, G. and Tarzia, G. (2008) Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr. Top. Med. Chem. 8, 954-968. https://doi.org/10.2174/156802608784936719
  150. Singareddy, R., Vgontzas, A. N., Fernandez-Mendoza, J., Liao, D., Calhoun, S., Shaffer, M. L. and Bixler, E. O. (2012) Risk factors for incident chronic insomnia: a general population prospective study. Sleep Med. 13, 346-353. https://doi.org/10.1016/j.sleep.2011.10.033
  151. Singer, H. S., Mink, J. W., Gilbert, D. L. and Jankovic, J. (2016) Chapter 19-Movements that occur in sleep. In Movement Disorders in Childhood (2nd ed.) (H. S. Singer, J. W. Mink, D. L. Gilbert and J. Jankovic, Eds.), pp. 427-451. Academic Press, Boston.
  152. Spira, A. P., Gamaldo, A. A., An, Y., Wu, M. N., Simonsick, E. M., Bilgel, M., Zhou, Y., Wong, D. F., Ferrucci, L. and Resnick, S. M. (2013) Self-reported sleep and beta-amyloid deposition in communitydwelling older adults. JAMA Neurol. 70, 1537-1543. https://doi.org/10.1001/jamaneurol.2013.4258
  153. Susic, V. (2007) Normal sleep. Glas-Srpska Akademija Nauka I Umetnosti 49, 1-6.
  154. Tannenbaum, C., Greaves, L. and Graham, I. D. (2016) Why sex and gender matter in implementation research. BMC Med. Res. Methodol. 16, 145. https://doi.org/10.1186/s12874-016-0247-7
  155. Tannenbaum, C., Paquette, A., Hilmer, S., Holroyd-Leduc, J. and Carnahan, R. (2012) A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs Aging 29, 639-658. https://doi.org/10.1007/BF03262280
  156. Tholfsen, L. K., Larsen, J. P., Schulz, J., Tysnes, O. B. and Gjerstad, M. D. (2015) Development of excessive daytime sleepiness in early Parkinson disease. Neurology 85, 162-168. https://doi.org/10.1212/WNL.0000000000001737
  157. Thorpy, M. J. (2012) Classification of sleep disorders. Neurotherapeutics 9, 687-701. https://doi.org/10.1007/s13311-012-0145-6
  158. Tranah, G. J., Blackwell, T., Stone, K. L., Ancoli-Israel, S., Paudel, M. L., Ensrud, K. E., Cauley, J. A., Redline, S., Hillier, T. A., Cummings, S. R. and Yaffe, K.; SOF Research Group (2011) Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann. Neurol. 70, 722-732. https://doi.org/10.1002/ana.22468
  159. Tsuno, N., Jaussent, I., Dauvilliers, Y., Touchon, J., Ritchie, K. and Besset, A. (2007) Determinants of excessive daytime sleepiness in a French community-dwelling elderly population. J. Sleep Res. 16, 364-371. https://doi.org/10.1111/j.1365-2869.2007.00606.x
  160. Vansickel, A. R., Stoops, W. W. and Rush, C. R. (2010) Human sex differences in d-amphetamine self-administration. Addiction 105, 727-731. https://doi.org/10.1111/j.1360-0443.2009.02858.x
  161. Wadworth, A. N. and McTavish, D. (1993) Zopiclone. A review of its pharmacological properties and therapeutic efficacy as an hypnotic. Drugs Aging 3, 441-459. https://doi.org/10.2165/00002512-199303050-00006
  162. Wagner, J. and Wagner, M. L. (2000) Non-benzodiazepines for the treatment of insomnia. Sleep Med. Rev. 4, 551-581. https://doi.org/10.1053/smrv.2000.0126
  163. Wan, H., Warburton, E. C., Zhu, X. O., Koder, T. J., Park, Y., Aggleton, J. P., Cho, K., Bashir, Z. I. and Brown, M. W. (2004) Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory. Eur. J. Neurosci. 20, 2214-2224. https://doi.org/10.1111/j.1460-9568.2004.03688.x
  164. Wang, J. and Huang, Y. (2007) Pharmacogenomics of sex difference in chemotherapeutic toxicity. Curr. Drug Discov. Technol. 4, 59-68. https://doi.org/10.2174/157016307781115485
  165. Wing, Y. K., Lam, S. P., Li, S. X., Yu, M. W., Fong, S. Y., Tsoh, J. M., Ho, C. K. and Lam, V. K. (2008) REM sleep behaviour disorder in Hong Kong Chinese: clinical outcome and gender comparison. J. Neurol. Neurosurg. Psychiatry 79, 1415-1416. https://doi.org/10.1136/jnnp.2008.155374
  166. Wing, Y. K., Lam, S. P., Zhang, J., Leung, E., Ho, C. L., Chen, S., Cheung, M. K., Li, S. X., Chan, J. W., Mok, V., Tsoh, J., Chan, A. and Ho, C. K. (2015) Reduced striatal dopamine transmission in REM sleep behavior disorder comorbid with depression. Neurology 84, 516-522. https://doi.org/10.1212/WNL.0000000000001215
  167. Wing, Y. K., Li, S. X., Mok, V., Lam, S. P., Tsoh, J., Chan, A., Yu, M. W., Lau, C. Y., Zhang, J. and Ho, C. K. (2012) Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 83, 470-472. https://doi.org/10.1136/jnnp-2011-301232
  168. Xie, Z., Chen, F., Li, W. A., Geng, X., Li, C., Meng, X., Feng, Y., Liu, W. and Yu, F. (2017) A review of sleep disorders and melatonin. Neurol. Res. 39, 559-565. https://doi.org/10.1080/01616412.2017.1315864
  169. Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S. and Stone, K. L. (2011) Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 306, 613-619.
  170. Yayeh, T., Leem, Y. H., Kim, K. M., Jung, J. C., Schwarz, J., Oh, K. W. and Oh, S. (2018) Administration of alphas1-casein hydrolysate increases sleep and modulates GABAA receptor subunit expression. Biomol. Ther. (Seoul) 26, 268-273. https://doi.org/10.4062/biomolther.2017.083
  171. Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S. and Badr, S. (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med. 328, 1230-1235. https://doi.org/10.1056/NEJM199304293281704
  172. Young, T. and Peppard, P. (2000) Sleep-disordered breathing and cardiovascular disease: epidemiologic evidence for a relationship. Sleep 23, S122-S126.
  173. Zammit, G., Erman, M., Wang-Weigand, S., Sainati, S., Zhang, J. and Roth, T. (2007) Evaluation of the efficacy and safety of ramelteon in subjects with chronic insomnia. J. Clin. Sleep Med. 3, 495-504. https://doi.org/10.5664/jcsm.26914
  174. Zhou, J., Zhang, J., Lam, S. P., Chan, J. W., Mok, V., Chan, A., Li, S. X., Liu, Y., Tang, X., Yung, W. H. and Wing, Y. K. (2017) Excessive daytime sleepiness predicts neurodegeneration in idiopathic REM sleep behavior disorder. Sleep 40, doi: 10.1093/sleep/zsx041.
  175. Zucker, I. and Beery, A. K. (2010) Males still dominate animal studies. Nature 465, 690. https://doi.org/10.1038/465690a

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