Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Traditional Herbal Medicine Yukmijihwang-won Alleviates Reserpine-Induced Pain and Depression-Like Behavior in Mice

  • Kang, Dong-Wook (Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University) ;
  • Lee, Jiyoon (Department of Neuropsychiatry, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Choi, Jae-Gyun (Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University) ;
  • Kim, Jaehyuk (Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University) ;
  • Kim, Ju-Yeon (Department of Neuropsychiatry, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Park, Jin Bong (Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University) ;
  • Jung, In Chul (Department of Neuropsychiatry, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Kim, Hyun-Woo (Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University)
  • Received : 2020.12.01
  • Accepted : 2020.12.18
  • Published : 2020.12.30
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Abstract

Objectives: Yukmijihwang-won (Liuweidihuang-wan in Chinese) is a frequently used medicinal herbal formula. It is used as Yin tonic in Korea and China to recover patients from Yin deficiency. However, the scientific evidence on this drug has not revealed the beneficial effect or mechanism of its effects on the neurological disorder. We designed this study to examine the antidepressive and analgesic effects of Yukmijihwang-won (YJ-01) and the minor modification of YJ-01, YJ-06 on the reserpine-induced pain-depression dyad mice model. Methods: Reserpine (1 mg/kg) was administered subcutaneously once a day for three consecutive days to induce pain and depression-like behavior. The oral administration of YJ-01 and YJ-06 (100, 200, or 300 mg/kg) was performed once daily from three days after the reserpine injection. Results: Repeated administration of the YJs significantly reduced the immobility time in a forced swimming test and increased the moved distance and number of crossings in the open field test. In the von-Frey filament test, the oral administration of YJs remarkably suppressed the increase in paw withdrawal frequency. Conclusions: The results of this study suggest that YJ-01 and 06 may be good candidates to treat the pain-depression dyad.

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