DOI QR코드

DOI QR Code

Clinical Report of 3 Cases of Herbal Medicine Treatment Applied with Polysomnography for Breathing-Related Sleep Disorders

수면다원검사를 적용한 호흡관련 수면장애 한약 치료 3례 증례 보고

  • Jeong, Jin-Hyung (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Jung, In-Chul (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Kim, Won-Il (Department of Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Bo-Kyung (Department of Neuropsychiatry, School of Korean Medicine, Pusan National University)
  • 정진형 (대전대학교 한의과대학 한방신경정신과교실) ;
  • 정인철 (대전대학교 한의과대학 한방신경정신과교실) ;
  • 김원일 (동의대학교 한의과대학 내과학교실) ;
  • 김보경 (부산대학교 한의학전문대학원 한방신경정신과교실)
  • Received : 2020.11.30
  • Accepted : 2020.12.19
  • Published : 2020.12.30

Abstract

Objectives: This case report intended to examine how herbal medicine treatment for breathingrelated sleep disorders applied with polysomnography affected the structure of sleep. Methods: From January to November 2019, we retrospectively reviewed the progress records and polysomnography reports of patients who visited Korean medical hospitals in Daejeon and Cheonan. Results: In case 1, the patient complained of daytime sleepiness and snoring and was diagnosed with obstructive sleep apnea disorder and treated with Ukgan-san-gami. There were significant changes in the polysomnographic parameters, such as sleep efficiency, waking after sleep onset, sleep latency, the total arousal index, and the apnea-hypopnea index after herbal treatment. In case 2, the patient complained of frequent waking after sleep onset, daytime sleepiness, and snoring, and was diagnosed with obstructive sleep apnea disorder and treated with Yeoldahanso-tang-gami. There were significant changes in the polysomnographic parameters, such as the total arousal index and the apnea-hypopnea index after herbal treatment. In case 3, the patient complained of daytime sleepiness and was diagnosed with obstructive sleep apnea disorder and treated with Bangpungtongsung-san. There was no significant change in the polysomnographic parameters after herbal treatment. Conclusions: It is meaningful to note that objectively identifying the outcome of treatment for breathing-related sleep disorders is necessary in the clinical practice of Korean medicine.

Keywords

References

  1. American Academy of Sleep Medicine. International Classification of Sleep Disorder, 3rd ed. Darien, IL. American Academy of Sleep Medicine. 2014:13-8.
  2. Rundo JV, Downey III R. Handbook of Clinical Neurology, Vol 160 Clinical Neurophysiology: Basis and Technical Aspects. Elsevier, B.V. 2019:381-92.
  3. The Textbook Compilation Committee of Neuropsychiatry of Oriental Schools in Nation. The Neuropsychiatry of Oriental Medicine. 3rd ed. Seoul. Jipmoon-Dang. 2016: 235-48.
  4. Ni X, Shergis JL, Guo X, Zhang AL, Li Y, Lu C, Xue CC. Undated clinical evidence of Chinese herbal medicine for insomnia: a systematic review and meta-analysis of randomized controlled trials. Sleep Medicine. 2015;16(2015): 1462-81. https://doi.org/10.1016/j.sleep.2015.08.012
  5. Yan M, Feng J, Jiang HL, Liu W, Wu LH, Qu B, M B. Traditional Chinese Medicine in Treatment of Obstructive Sleep Apnea Syndrome: A Systematic Review. Modern Preventive Medicine 2016;43(14):2672-7.
  6. Chung HS, Kim HS. Case Report of Three Cases of Obstructive Sleep Apnea Improved with Oriental Medicine Treatment. J Korean Oriental Med. 2012;33(1):169-76.
  7. Berry RB, Albertario CL, Harding SM, et al; for the American Academy of Sleep Medicine. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Version 2.5. Darien, IL: American Academy of Sleep Medicine. 2018:7-65.
  8. Hishkowitz M. The History of Polysomnography: Tool of scientific Discovery. In: Chokroverty S., Billiard M. (eds) Sleep Medicine. Springer, New York, NY. 2015:91-99.
  9. Leach MJ, Page AT. Herbal medicine for insomnia: A systematic review and meta-analysis. Sleep Medicine Reviews. 2015;24(2015):1-12. https://doi.org/10.1016/j.smrv.2014.12.003
  10. Zhou QH, Zhou XL, Xu MB, Jin TY, Rong PQ, Zheng GQ, Lin Yan. Suanzaoren Formulae for Insomnia: Updated Clinical Evidence and Possible Mechanisms. Front Pharmacol. 2018;9(76):1-12. https://doi.org/10.3389/fphar.2018.00001
  11. Cho YW, Song ML, Morin CM. Validation of a Korean Version of the Insomnia Severity Index. Journal of Clinical Neurology. 2014;10(3):210-5. https://doi.org/10.3988/jcn.2014.10.3.210
  12. Sohn SI, Kim DH, Lee MY. The reliability and validity of the Korean version of the Pittsburgh Sleep Quality Index. Sleep and Breathing, 2012;16(3):803-12. https://doi.org/10.1007/s11325-011-0579-9
  13. Cho YW, Lee JH, Son HK, Lee SH, Shin C, Johns MW. The reliability and validity of the Korean version of the Epworth sleepiness scale. Sleep and Breathing. 2011;15(3):377-84. https://doi.org/10.1007/s11325-010-0343-6
  14. Kim MG, Park SS. A study of constitutional disease with sleep as constitutional symptom. J of Sasang Constitutional Medicine. 2004;16(2):52-7.
  15. Azushima K, Tamura K, Haku S, et al. Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group. Atherosclerosis. 2015;240(1):297-304. https://doi.org/10.1016/j.atherosclerosis.2015.01.025
  16. Su J, Li L, Zhong LP. Clinical Study on the Decoction for Clearing away Gallbladder-Heat with Coptidis for the Treatment of Obstructive Sleep Apnea Hypopnea Syndrome. zhongguo zhongyiyao xinxi zazhi. 2004;11(10): 854-5.
  17. Chen Q, Lin RJ, Hong XC, Ye L, Lin QC. Treatment and prevention of inflammatory responses and oxidative stress in patients with obstructive sleep apnea hypopnea syndrome using Chinese herbal medicines. Experimental and therapeutic medicine. 2016;12(2016):1572-8. https://doi.org/10.3892/etm.2016.3484
  18. Hisanaga A, Itoh T, Hasegawa Y, Emori K, Kita T, Okabe A, Kurachi M. A case of sleep choking syndrome improved by the Kampo extract of Hange-koboku-to. Psychiatry Clin Neurosci. 2002;56(3):325-7. https://doi.org/10.1046/j.1440-1819.2002.01001.x
  19. Hisanaga A, Saitoh O, Fukuda H, et al. Treatment of obstructive sleep apnea syndrome with a Kampo-formula, San'o-shashin-to: a case report. Psychiatry Clin Neurosci. 1999;53(2):303-5. https://doi.org/10.1046/j.1440-1819.1999.00512.x
  20. Eichling PS. Emphasizing the Complementary in CAM. Journal of Clinical Sleep Medicine. 2007;3(6):580-1. https://doi.org/10.5664/jcsm.26967
  21. Levy P, Kohler M, McNicholas WT, Barbe F, McEvoy RD, Somers VK, Lavie L, Pepin JL. Obstructive sleep apnoea syndrome. Nat Rev Dis Primers. 2015;1(2015):15015. https://doi.org/10.1038/nrdp.2015.15