Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo

  • Lee, Jin Woo (Research & Development Center, Richwood Pharmaceuticals) ;
  • Park, Se Hoon (Research & Development Center, Richwood Pharmaceuticals) ;
  • Jegal, Chang Min (Research & Development Center, Richwood Pharmaceuticals) ;
  • Choi, Keun Young (Research & Development Center, Richwood Pharmaceuticals) ;
  • Jung, Hye Young (Research & Development Center, Richwood Pharmaceuticals) ;
  • Choi, Jung A (Research & Development Center, Richwood Pharmaceuticals) ;
  • Lee, Chan Kyu (Research & Development Center, Richwood Pharmaceuticals) ;
  • Kim, Ho Kyong (Research & Development Center, Richwood Pharmaceuticals) ;
  • Lee, Jung Suk (Research & Development Center, Richwood Pharmaceuticals) ;
  • Lee, Il Kyun (Research & Development Center, Richwood Pharmaceuticals)
  • Received : 2020.04.10
  • Accepted : 2020.07.20
  • Published : 2020.12.31
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Abstract

In this study, we investigated the chemical profile and effects of RW0117 (Artemisia argyi 65 .5 % ethanol extract) on gastric lesions in rats. We optimized and validated a method to obtain the chemical profile of RW0117. We then investigated the antioxidant and anti-inflammatory effects in vitro, and the protective effects on gastric lesions in vivo. The IC50 of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging considering the antioxidant effects of RW0117 was 166.55 ㎍/mL, and the IC50 of nitric oxide scavenging considering the anti-inflammatory effects was 41.16 ㎍/mL. Oral administration of RW0117 at lower concentrations (25, 50, 100 mg/kg) had similar or greater effects than the daily intake conversion concentration (115mg/kg) of a health functional food (Avexol®) in the acetic acid-induced ulcer and the ethanol-induced gastric injury rat models. In addition, oral administration of RW0117 increased the expression of prostaglandin E2, which enhances the protective effect in the gastric mucosa in the ethanol-induced gastric injury rat model. These results suggest that RW0117 may have potential therapeutic uses in the protection of the gastric mucosa.

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References

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