Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities

  • Dongmo, Arnaud Joseph Nguetse (Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang) ;
  • Ekom, Steve Endeguele (Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang) ;
  • Tamokou, Jean-de-Dieu (Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang) ;
  • Tagousop, Cyrille Ngoufack (Department of Basic Scientific Studies, University Institute of Technology, University of Ngaoundere) ;
  • Harakat, Dominique (Service Commun d'Analyses, Institut de Chimie Moleculaire de Reims (ICMR)) ;
  • Voutquenne-Nazabadioko, Laurence (Groupe Isolement et Structure, Institut de Chimie Moleculaire de Reims (ICMR)) ;
  • Ngnokam, David (Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang)
  • Received : 2020.10.24
  • Accepted : 2020.12.02
  • Published : 2020.12.31
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Abstract

A new dimer stilbene [Monalittorin (1)] and ten known compounds [engeletin (2), aurantiamide acetate (3), lupeol (4), friedelin (5), quercetin (6), tiliroside (7), rutoside (8), astragalin (9), isoquercitrin (10) and quercimeritroside (11)] have been isolated from the leaves of Monanthotaxis littoralis (Annonaceae). The structures of these compounds were established by interpretation of their data, mainly, HR-TOFESIMS, 1-D NMR (1H and 13C) and 2-D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and by comparison with the literature. The evaluation of their antimicrobial activities against three bacteria (Staphylococcus aureus ATCC 25923, Escherichia coli S2 (1) and Pseudomonas aeruginosa PA01) and three fungal strains (Candida albicans ATCC10231, Candida tropicalis PK233 and Cryptococcus neoformans H99) using broth micro dilution method, showed the largest antimicrobial activities of EtOAc fraction and compounds 1, 5, 6, 8 and 11 (MIC = 8 - 64 ㎍/mL). In addition, EtOAc fraction presented synergistic effect with Vancomycin and fluconazole against the tested microorganisms.

Keywords

References

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