Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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A Review on Clinical Research Trend in Treatment of Chai-Hu-Shu-Gan-San (Sihosogan-San) for Insomnia

불면증에 대한 시호소간산 치료의 임상연구 동향

  • Lee, Jae-Eun (School of Korean Medicine, Pusan National University) ;
  • Kim, Sang-Ho (Department of Neuropsychiatry of Korean Medicine, Pohang Korean Medicine Hospital Affiliated to Daegu Haany University) ;
  • Kim, Bo-Kyung (Department of Neuropsychiatry, School of Korean Medicine, Pusan National University) ;
  • Lim, Jung-Hwa (Department of Neuropsychiatry, School of Korean Medicine, Pusan National University)
  • 이재은 (부산대학교 한의학전문대학원) ;
  • 김상호 (대구한의대부속 포항한방병원 한방신경정신과) ;
  • 김보경 (부산대학교 한의학전문대학원 한방신경정신과교실) ;
  • 임정화 (부산대학교 한의학전문대학원 한방신경정신과교실)
  • Received : 2020.02.25
  • Accepted : 2020.03.16
  • Published : 2020.03.30
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Abstract

Objectives: This review aimed to investigate the effectiveness of Chai-Hu-Shu-Gan-San (CHSGS) for treatment of insomnia. Methods: 9 databases were comprehensively searched from their inception dates until Jan 2020 using keywords like Insomnia, Chai-Hu-Shu-Gan-San and Sihosogan-san. We included randomized controlled trials (RCTs) using CHSGS as the main intervention for insomnia patients. We assessed the quality of RCTs using the Cochrane risk of bias tool and Jadad scale. Results: 5 RCTs were included. The Chinese classification of mental disorders -3 (CCMD-3) was the most frequently used diagnostic criteria. The effective rate was the most frequently used as outcome. All the 5 RCTs that reported CHSGS and CHSGS adjunctive therapy on insomnia were more effective compared to western medication. Only one study reported adverse effects. The methodological quality of the included RCTs were generally poor. Conclusions: This review found that CHSGS may be effective to treating insomnia. However, because of the small number, heterogeneity and very low methodological quality of included studies, we could not draw any definitive conclusions. Therefore, more rigorous randomized control studies are warranted.

Keywords

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