The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Chemical change of urushiol during heating process of Toxicodendron vernicifluum resin

Urushiol의 화학적 변화를 통한 건칠(乾漆)의 포제법(炮製法) 고찰

  • Kim, Jung-Hoon (Division of Pharmacology, School of Korean Medicine, Pusan National Univ.) ;
  • Doh, Eui jeong (Research Center of Traditional Korean Medicine, Wonkwang Univ.) ;
  • Lee, Guemsan (Research Center of Traditional Korean Medicine, Wonkwang Univ.)
  • 김정훈 (부산대학교 한의학전문대학원 약물의학부) ;
  • 도의정 (원광대학교 한국전통의학연구소) ;
  • 이금산 (원광대학교 한국전통의학연구소)
  • Received : 2020.01.10
  • Accepted : 2020.03.25
  • Published : 2020.03.30
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Abstract

Objectives : Heating process is the traditional processing method that has been applied to reduce the toxicity of dried resin of Toxicodendron vernicifluum (Anacardiacea) used as Geon-chil (乾漆, Lacca Rhois Exsiccata or Toxicodendri Resina). Urushiol, which is found in the plants of Toxicodendron genus, is a toxic compound that is absorbed into the skin and induces allergic dermatitis by being contacted. Hence, the reduction of urushiol level by heating processing of Geon-chil is crucial method for its medicinal application. Methods : Due to lack of Geon-chil processing-related articles, the articles researching the processing of lacquer (漆), as a coating material, were collected and analyzed to investigate the chemical change of urushiol during heating process. Results : The results demonstrate that the resin which was collected from the sap of T. vernicifluum tree was dried under warm and humid conditions repeatedly. During primary drying process, the laccase, a copper-containing enzyme in the resin, participated in the formation of urushiol polymers and thereafter urushiol-related toxicity could be reduced by making a lacquer harder and more stable. Moreover, heating a lacquer over 200℃ could cause thermo-degradation of urushiol polymers, and vaporized thermally degraded urushiol monomers and their by-products, which were determined using pyrolysis/GC-MS. Conclusions : These results support that heating process being performed over 200 ℃, such as stir-frying (炒) or calcination (煅), reduces the urushiol content in Geon-chil and hence, its medicinal use can be more stable without urushiol-related allergic reactions.

Keywords

References

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