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Purity assessment using quantitative NMR: establishment of SI traceability in organic analysis

  • Choi, Kihwan (Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science)
  • Received : 2020.03.17
  • Accepted : 2020.03.19
  • Published : 2020.03.20

Abstract

Quantitative nuclear magnetic resonance (qNMR) has been gaining attention as a purity assessment method. In particular, qNMR is recognized as the primary method to realize the Internal System of Units (SI) in organic analysis. The capability of quantitative analysis is recognized as the beginning of NMR development. NMR signals are proportional to the number of nuclei and qNMR has been used in various fields, such as metabolomics and food and pharmaceutical analysis. However, careful sample preparation and thorough optimization of measurement parameters are required to obtain accurate and reliable results. In this review, quantitative methods used in qNMR are discussed, and the important factors to be considered also introduced. The recent development of qNMR techniques including combination with chromatography and, multidimensional NMR are also presented.

Keywords

Acknowledgement

Grant : Establishing measurement standards for organic analysis

Supported by : Korea Research Institute of Standards and Science

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