Journal of the Korea Convergence Society (한국융합학회논문지)

Korea Convergence Society (한국융합학회)
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A convergence study on the Positive Rate of Hepatitis B Surface Antibody by Age before and after HBV Vaccination

B형 간염 예방접종 전후 연령별 B형 간염 표면항체 양성률에 대한 융합적 연구

  • Kim, Jiro (Department of Clinical Laboratory Science, Cheju Halla University) ;
  • Lee, Kyu-taeg (Department of Laboratory Medicine, Cheju Halla General Hospital) ;
  • Chong, Moo-Sang (Department of Clinical Laboratory Science, Cheju Halla University)
  • 김지로 (제주한라대학교 임상병리과) ;
  • 이규택 (제주한라병원 검사의학과) ;
  • 정무상 (제주한라대학교 임상병리과)
  • Received : 2019.10.24
  • Accepted : 2020.01.20
  • Published : 2020.01.28
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Abstract

In order to analyze the positive rate of hepatitis B surface antibody by age before and after hepatitis B vaccination, 13,855 serum specimens who were referred for the hepatitis B surface antibody test at the General Hospital of Jeju Hospital were examined by CMIA method. The positive rate of HBs Ab was 5,176 (37.36%). The positive rate according to gender was 40.13% for female and 34.77% for male. The age group with the highest HBs Ab average was in their 40's (399.86 mIU/mL), while the lowest age group was in the 90's (211.50 mIU/mL). It is remarkable that the age group with the highest HBs Ab positive rate is in the 30's, and that teenagers (age group of 10-20 years) had the lowest positive rate. Especially 15, 18, 19 years old was statistically significant. Consideration should be given to determining the titer of vaccination and to clarify the timing of vaccination.

B형 간염 예방접종 전후 연령별 B형 간염 표면항체 양성률을 분석하기 위하여 제주지역 종합병원 검사의학과에 B형 간염 표면항체 검사가 의뢰된 13,855명의 혈청 검체를 대상으로 CMIA법으로 조사하였다. HBs Ab 양성률은 5,176건으로 37.36%이었으며, 성별에 따른 양성률은 여자가 40.13%로 남자의 34.77%보다 높게 나타났다. HBs Ab 측정 평균값이 가장 높은 연령군은 40대(399.86 mIU/mL)이었으며, 가장 낮은 연령군은 90대(211.50 mIU/mL)로 나타났다. HBs Ab 양성률이 가장 높은 연령군은 30대이며, 10대의 양성률이 가장 낮은 분포를 보인 것은 주목할 만하다. 10대~20대의 B형 간염 표면항체 양성률이 현저히 감소하는 경향을 보였으며, 특히 15, 18, 19세가 통계적으로 유의하였다. 이에 예방접종의 역가의 측정을 고려하고 추가접종 시기를 명확히 해야 한다고 사료된다.

Keywords

References

  1. W. K. Lee. (2003). Characteristics of Hepatitis B Virus(HBV) and HBV DNA Quantitative Tests. Korean J Clin Microbiol, 6(2), 89-96.
  2. H. M. Koh & J. S. Son. (2015). Seroprevalence of Hepatitis A and B Virus Antibody of Employees among Three Companies with Different Health Policy. J Korean Soc Occup Environ Hyg, 25(2), 229-235. DOI : 10.15269/jksoeh.2015.25.2.229
  3. Y. J. Choi, K. S. Bae, K. H. Kim, D. K. Koh & J. H. Kim. (2018). Therapeutic Efficacy of Lamivudine in Children and Adolescents with Chronic Hepatitis B. Pediatr Infect Vaccine, 25(2), 72-81. DOI : 10.14776/piv.2018.25.e2
  4. Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. (2015). Korea Health Statistics 2014: Korea National Health and Nutrition Examination Survey (KNHANES VI-2). Sejong: Ministry of Health and Welfare.
  5. J. H. Kim, K. Seo & H. M. Kim. (2006). A comparative study for the outcome of perinatal hepatitis B prophylaxis according to the dosages of hepatitis B immunoglobulin. Seoul: Korea Centers for Disease Control and Prevention.
  6. E. S. Jang. (2013). Diagnostic Tests for Viral Hepatitis. Korean J Med, 85(3), 267-271. DOI : 10.3904/kjm.2013.85.3.267
  7. H. M. Kang et al. (2007). Recent etiology and clinical features of acute viral hepatitis in a single center of Korea. Korean J Hepatol, 13(4), 495-502. DOI : 10.3350/kjhep.2007.13.4.495
  8. K. Kim & D. A. Kim. (2013). The Comparison between Serologic Tests and Magicplex HepaTrio Real-time PCR in the Diagnosis of Viral Hepatitis. Lab Med Online, 3(1), 23-28 DOI : 10.3343/lmo.2013.3.1.23
  9. J. R. Kim. (1979). Study of hepatitis B vaccine. JKMA, 22, 1013-1025.
  10. M. H. Lee. (2015). The Positive Rates of Anti-HBs and Titers of Antibody after Hepatitis B Vaccination. Korean J Clin Lab Sci, 47(2), 78-82. DOI : 10.15324/kjcls.2015.47.2.78
  11. H. B. Chae, J. H. Kim, J. K. Kim & H. J. Yim. (2009). Current status of liver diseases in Korea: hepatitis B. Korean J Hepatol, 15(Suppl 6), S13-S24. DOI : 10.3350/kjhep.2009.15.s6.s13
  12. S. Jeong, H. W. Yim, S. H. Bae & W. C. Lee. (2008). Changes of hepatitis B surface antigen seroprevalence in Korea, 1998-2005. Korean J Epidemiol, 30(1), 119-127. DOI : 10.4178/kje.2008.30.1.119
  13. W. Jilg, M. SChmit & F. Deinhard. (1988). Persistence of specifics antibodies after hepatitis B vaccination. J hepatology, 6(2), 201-207. DOI : 10.1016/s0168-8278(88)80032-1
  14. I. T. Williams, S. T. Goldstein, J. Tufa, S. Tauilli, H. S. Margolis & F. J. Mahoney. (2003). Long term antibody response to hepatitis B vaccination beginning at birth and to subsequent booster vaccination. Pediatr Infect Dis J, 22(2), 157-163. DOI : 10.1097/01.inf.0000050463.28917.25
  15. S. M. Song, W. I. Oh & D. W. Kim. (2002). Evaluation of Serologic Marker Tests for Hepatitis B Viral Infection Using the Automated Immunoassay System ARCHITECT i2000. Korean J Clin Pathol, 22(1), 42-46.
  16. J. G. Sim, J. K. Seo, S. J. Suh. (1995). Prevalence and its changes of hepatitis B ciral markers from 1988 to 1993 in Korean children. J Korean Pediatr Soc, 38(11), 1535-1539.
  17. S. J. Lee et al. (2001). A study on the change of HBsAg and Anti HBs positivies for a recent 15 year period in Korea. Korean J Hepatol, 7(3), 299-307.
  18. Y. K. Cho & B. C. Song. (2012). Prevention of Viral Hepatitis and Vaccination. Korean J Med, 82(2), 123-133. DOI : 10.3904/kjm.2012.82.2.123
  19. M. H. Lee. (2015). The Positive Rates of Anti-HBs and Titers of Antibody after Hepatitis B Vaccination. Korean J Clin Lab Sci, 47(2), 78-82. DOI : 10.15324/kjcls.2015.47.2.78
  20. A. Goudeau F. Dubois, G. Barin, MC. Dubois & P. Coursaget. (1983). Hepatitis B vaccine: Clinical trials high risk settings in France (September 1975-September 1982). Develop Biol Standard, 54, 267-278.
  21. J. H. Na, H. M. Cho, K. T. Chung, S. Woo. Choi, M. J. Park & S. J. Sohn. (2006). Sero-Prevalence of Hepatitis B Virus in University Students. J Agri Med & Community Health, 31(3), 245-253.
  22. J. H. Seo. (2003). Hepatitis B Surface Antigen and Antibody Positive Rates of Children and Adolescents in Jeju. Clinical and Molecular Hepatology, 9(4), 304-314.
  23. M. K. Jang, J. Y. Lee, J. H. Lee, Y. B. Kim, H. Y. Kim & J. Y. Yoo. (2000). The investigation for the change of HBs Ag positive rate of grade.junior high.high-schoolers for recent 3 years in Kang won province. Korean J Med, 58(6), 608-615.
  24. D. J. West & G. B. Calandra. (1996). Vaccine induced immunologic memory for hepatitis B surface antigen: implications for policy on booster vaccination. Vaccine, 14(11), 1019-1027. DOI : 10.1016/0264-410x(96)00062-x