Design of Dissolution Apparatus for the Flow-through Cell Method Based on the Low Pulsation Peristaltic Pump

저 맥동 연동 펌프 기반 플로우 스루 셀 방식 용출 장치 설계

  • Zhao, Jun Cheng (Department of Electronic Information Engineering., Yanbian University) ;
  • Cheng, Shuo (Ganting Network Technology Co., Ltd.) ;
  • Piao, Xiang Fan (Department of Electronic Information Engineering., Yanbian University)
  • 조준성 (연변대학교 공학원 전자정보학과) ;
  • 정석 (간팅인터넷기술) ;
  • 박상범 (연변대학교 공학원 전자정보학과)
  • Received : 2019.09.28
  • Accepted : 2019.10.20
  • Published : 2020.01.31


The emergence of the flow-through cell (FTC) method has made up for the limitations of previous dissolution test methods, but the high cost of the FTC dissolution devices have seriously hindered the progression of research and application of the FTC. This new design uses a peristaltic pump to simulate the sinusoidal flow rate of a piston pump. The flow profile of each peristaltic pump was sinusoidal with a pulsation of 120 ± 1 pulses per minute, and the flow rate ranged from 1.0 - 36.0 mL/min. The flow control of each channel was adjusted independently so the flow errors of the seven channels were close to 2%. The structure of the system was simplified, and the cost was reduced through manual sampling and immersing the FTC in a water bath. The dissolution rate of the theophylline and aminophylline films was determined, and good experimental results were obtained.


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