Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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The Availability of Amplitude, Asymmetry and Mean Frequency of Alpha Intrinsic Rhythm in Old Age as Brain Health Indicators

노년기 알파 고유리듬 진폭, 비대칭 및 평균 주파수의 뇌건강 지표로써 활용 가능성 연구

  • Shim, Jun-Young (Department of Brain Education, University of brain Education)
  • 심준영 (국제뇌교육종합대학원대학교 뇌교육학과)
  • Received : 2019.12.20
  • Accepted : 2020.02.07
  • Published : 2020.02.29
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Abstract

This study examines the clinical availability of alpha amplitude, asymmetry and mean frequency in old age as EEG indexes reflecting brain health condition. The EEGs of prefrontal lobes in eye closure state were measured for 4 minutes with 72 male and female elderly people aged 73. Subjects were divided into higher and lower groups based on average values of alpha amplitude, asymmetry and mean frequency. The results of correlations and t-test among EEG indexes were as follows. First, the higher Alpha altitude was, the higher physical and mental stress resistance and left-to-right brain communication were, and the lower mean Alpha mean frequency location was. The higher Alpha asymmetry was, the lower left-to-right communication level was. Second, as Alpha power of right brain was higher than that of left brain, Alpha amplitude and mental stress resistance and left-to-right brain communication level were higher. Third, as Alpha mean frequency location was higher, Alpha amplitude and mental anti-stress level were lowered and arousal level was enhanced. These high correlations and complementary meaning among quantitative EEG indicators demonstrated the possibility of biomarkers reflecting brain health state in old age.

본 연구는 노년기 Alpha 리듬의 진폭, 비대칭 및 평균 주파수가 뇌건강 상태를 반영할 수 있는 뇌파 지표로써 임상적 활용 가능성이 있는지 알아보고자 하였다. 이를 위하여 평균 나이 73세 남녀 노인 72명을 대상으로 폐안 시 전전두엽의 뇌파를 4분간 측정하였다. 집단 구분은 Alpha 진폭, 비대칭 및 평균주파수의 평균값을 각각 기준으로 높은집단과 낮은집단으로 분류하였다. 뇌파 지표들 간 상관관계와 t-검정을 실시한 결과는 다음과 같다. 첫 번째, Alpha 진폭이 높아지면 육체적·정신적 스트레스 저항도와 좌·우뇌 소통수준도 높아졌으며, Alpha 평균주파수 위치는 낮아졌다. 또한 Alpha 비대칭이 높아지면 좌·우뇌의 소통수준은 낮아지는 상관관계를 보였다. 두 번째, 좌뇌에 비해 우뇌의 Alpha 파워가 높아지면 Alpha 진폭과 정신적 스트레스 저항도, 좌·우뇌 소통수준도 높아졌다. 세 번째, Alpha 평균주파수 위치가 높아지면 Alpha 진폭과 정신적 항스트레스 지표는 낮아지고 각성 수준은 높아졌다. 이상과 같이 정량화 뇌파 지표들은 서로 간 관련성이 높고, 보완적 의미가 있어 노년기 뇌건강 상태를 반영하는 생체 표지자로써의 가능성을 보여주었다.

Keywords

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