- Volume 52 Issue 2
DOI QR Code
Corn silk extracts did not alter the adiposity and underlying substrate utilization in high-fat diet-induced obese C57BL/6 mice
- Kang, Eun Young (Department of Food and Nutrition, Hanyang University) ;
- Kim, Hyun Kyung (Department of Food and Nutrition, Hanyang University) ;
- Moyo, Knowledge Mudhibadhi (Department of Food and Nutrition, Hanyang University) ;
- Gang, Gyoungok (Department of Animal Science, Texas A&M University) ;
- Kim, Wooki (Department of Food Science and Biotechnology, Kyung Hee University) ;
- Go, Gwang-woong (Department of Food and Nutrition, Hanyang University)
- Received : 2020.02.21
- Accepted : 2020.04.03
- Published : 2020.04.30
Corn silk (Okmi-su) was anciently adopted as a material for tea or beverage. Corn silk extracts (CSE) contain bioactive phytochemicals such as phenolic acid, flavonoids, ascorbic acid, tannins, and glycosides. Under the impact of these functional components, CSE has benefits for antioxidation, diuresis, anti-diabetes, and dyslipidemia recovery. Nonetheless, its role in whole-body adiposity was not investigated; therefore, the effects of CSE on obesity were evaluated in high-fat diet-induced obese mice. Mice were assigned to either group (n=12); 1) normal diet (18% kcal from fat), 2) high-fat diet (45% kcal from fat, the control), 3) high-fat diet with CSE (800 mg/kg diet), and 4) high-fat diet with orlistat (500 mg/kg diet, a comparable control for weight loss). Our results showed that body weight, adiposity, and energy expenditure in obese mice were not altered by CSE. Lean body mass tended to decrease by CSE, which can be explained by stimulation of diuresis (p=0.06). In conclusion, our results suggest that dietary consumption of CSE does not influence the adiposity and underlying substrate utilization in high-fat diet-induced obese mice.
Supported by : Kwangdong Co. Ltd.
- Ali RFM, El-Anany AM. Stabilization of neem oil biodiesel with corn silk extract during long-term storage. J. Oleo Sci. 66: 133-145 (2017) https://doi.org/10.5650/jos.ess16146
- Bio Resource Information Service. Zea mays L. Available from: https://bris.go.kr/portal/resource/book/selectResourceBookDtlInfo.do?lfrcMnno=MANUIP3300100007&gubun=1&siteGb=P&menuNo=200221. Accessed Feb. 19, 2020.
- Cha JH, Kim SR, Kang HJ, Kim MH, Ha AW, Kim WK. Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets. Nutr. Res. Pract. 10: 501-506 (2016) https://doi.org/10.4162/nrp.2016.10.5.501
- Chaiittianan R, Chayopas P, Rattanathongkom A, Tippayawat P, Sutthanut K. Anti-obesity potential of corn silks: relationships of phytochemicals and antioxidation, anti-pre-adipocyte proliferation, anti-adipogenesis, and lipolysis induction. J. Funct. Foods. 23: 497-510 (2016) https://doi.org/10.1016/j.jff.2016.03.010
- Food Information Statistics System. POS Retail Sales by item. 2017. Available from: https://www.atfis.or.kr/sales/M002020000/view.do?searchItem=CD00000579&searchDivision=CD00000600&searchCompany=2&searchYear=2017&searchQuarter=3&selectAccessHistoryIdx. Accessed Feb. 19, 2020.
- Guo J, Liu T, Han L, Liu Y. The effects of corn silk on glycaemic metabolism. Nutr. Metab. 6: 47 (2009) https://doi.org/10.1186/1743-7075-6-47
- Hasanudin K, Hashim P, Mustafa S. Corn silk (Stigma maydis) in healthcare: a phytochemical and pharmacological review. Molecules. 17: 9697-9715 (2012) https://doi.org/10.3390/molecules17089697
- Korean Society for the Study of Obesity. Guidelines for treating obesity. 2014. Available from: http://general.kosso.or.kr/html/?pmode=BBBS0001300003&page=1&smode=view&seq=1214&searchValue=&searchTitle=strTitle. Accessed Feb. 19, 2020.
- Korean Society for the Study of Obesity. Guidelines for treating obesity. 2016. Available from: http://www.kosso.or.kr/file/2017_Obesity_Fact_Sheet.pdf. Accessed Feb. 20, 2020.
- Lee EY, Kim SL, Kang HJ, Kim MH, Ha AW, Kim WK. High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets. Nutr. Res. Pract. 10: 575-582 (2016) https://doi.org/10.4162/nrp.2016.10.6.575
- Lucas N, Legrand R, Deroissart C, Dominique M, Azhar S, Le Solliec MA, Leon F, Do Rego JC, Déchelotte P, Fetissov SO, Lambert G. Hafnia alvei HA4597 strain reduces food intake and body weight gain and improves body composition, glucose, and lipid metabolism in a mouse model of hyperphagic obesity. Microorganisms. 8: 35 (2020)
- Maksimoviae Z, Maleneiae D, Kovaeeviae N. Polyphenol contents and antioxidant activity of Maydis stigma extracts. Bioresour. Technol. 96: 873-877 (2005) https://doi.org/10.1016/j.biortech.2004.09.006
- Ministry of Food and Drug Safety. information of base material. Available from: https://www.foodsafetykorea.go.kr/portal/board/board.do?menu_grp=MENU_NEW01&menu_no=2660. Accessed Feb. 19, 2020.
- Rodriiguez-Peirez C, Segura-Carretero A, Del Mar Contreras M. Phenolic compounds as natural and multifunctional anti-obesity agents: a review. Crit. Rev. Food Sci. Nutr. 59: 1212-1229 (2019) https://doi.org/10.1080/10408398.2017.1399859
- Saheed S, Oladipipo AE, Abdulazeez AA, Olarewaju SA, Ismaila NO, Emmanuel IA, Fatimah QD, Aisha AY. Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats. Toxicol. Rep. 2: 638-644 (2015) https://doi.org/10.1016/j.toxrep.2015.04.001
- Sepehri G, Derakhshanfar A, Zadeh FY. Protective effects of corn silk extract administration on gentamicin-induced nephrotoxicity in rat. Comp. Clin. Path. 20: 89-94 (2011) https://doi.org/10.1007/s00580-009-0943-3
- Stewart LK, Soileau JL, Ribnicky D, Wang ZQ, Raskin I, Poulev A, Majewski M, Cefalu WT, Gettys TW. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism. 57: S39-S46 (2008) https://doi.org/10.1016/j.metabol.2008.03.003
- Trigueros L, Pena S, Ugidos AV, Sayas-Barberal E, Perez-Alvarez JA, Sendra E. Food ingredients as anti-obesity agents: a review. Crit. Rev. food sci. and nutr. 53: 929-942 (2013) https://doi.org/10.1080/10408398.2011.574215
- Triutomo DH, Miranda A, Tamba LJ, Lukitaningsih E. Estrogenic effect ethanol extract corn silk (Stigma maydis) on bone density and histology femur profiles in ovariectomized rats female sprague dawley strain. Indones. J. Cancer. Chemoprevent. 7: 104-109 (2016)
- Velazquez DVO, Xavier HS, Batista JEM, De Castro-Chaves C. Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats. Phytomedicine. 12: 363-369 (2005) https://doi.org/10.1016/j.phymed.2003.12.010
- Zhang X, Li X, Fang H, Guo F, Li F, Chen A, Huang S. Flavonoids as inducers of white adipose tissue browning and thermogenesis: signaling pathways and molecular triggers. Nutr. Metab. 16: 47 (2019) https://doi.org/10.1186/s12986-019-0370-7