Journal of Korean society of Dental Hygiene (한국치위생학회지)

Korean Society of Dental Hygiene (한국치위생학회)
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Association between self-assessed gingival bleeding and halitosis, and glycated hemoglobin levels in patients with diabetes

제2형 당뇨병 환자에서 자가 인식한 치은 출혈 및 구취와 당화혈색소 간의 연관성

  • Received : 2019.11.25
  • Accepted : 2020.01.05
  • Published : 2020.02.28
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Abstract

Objectives: This study aimed to analyze the association between self-assessed periodontal symptoms and glycated hemoglobin levels in patients with type 2 diabetes. Methods: This cross-sectional study involved 156 patients with type 2 diabetes who were aged 50 years or older. Structured questionnaires were used to investigate the self-assessed periodontal symptoms of the patients. The glycated hemoglobin test was performed to evaluate their long-term blood glycemic control. Chi-square test and logistic multiple regression were performed to analyze the factors associated with glycated hemoglobin levels. Results: Compared with patients aged 65 years and above, more patients aged 64 years and below showed poor glycemic control (p=0.020). Further, compared with patients without self-perceived gingival bleeding and halitosis, more patients with these two conditions showed poor glycemic control (p<0.05). Compared with the group of patients without any periodontal symptoms, the group of patients that had at least one periodontal symptom had a higher proportion of patients with poor glycemic control (p<0.001). In the logistic regression model, gingival bleeding and halitosis were the factors most associated with hyperglycemia (p<0.05). Conclusions: The results of our study suggest that gingival bleeding and halitosis can predict hyperglycemia in patients with type 2 diabetes.

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References

  1. Karakaya J, Akin S, Karagaoglu E, Gurlek A. The performance of hemoglobin A1c against fasting plasma glucose and oral glucose tolerance test in detecting prediabetes and diabetes. J Res Med Sci 2014;19(11):1051-7.
  2. Chung JKO, Xue H, Pang EWH, Tam DCC. Accuracy of fasting plasma glucose and hemoglobin A1c testing for the early detection of diabetes: a pilot study. Frontiers in Laboratory Medicine 2017;1(2):76-81. https://doi.org/10.1016/j.flm.2017.06.002
  3. Ministry of Health & Welfare. Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey(KNHANES VII-1). Sejong: Ministry of Health & Welfare: 2017: 52-3.
  4. Alam U, Asghar O, Azmi S, Malik RA. General aspects of diabetes mellitus. Handb Clin Neurol 2014;126:211-22. https://doi.org/10.1016/B978-0-444-53480-4.00015-1
  5. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006;116(7):1793-801. https://doi.org/10.1172/JCI29069
  6. Costa KL, Taboza ZA, Angelino GB, Silveira VR, Montenegro R Jr, Haas AN, et al. Influence of periodontal disease on changes of glycated hemoglobin levels in patients with type 2 diabetes mellitus: a retrospective cohort study. J Periodontol 2017;88(1):17-25. https://doi.org/10.1902/jop.2016.160140
  7. Albert DA, Ward A, Allweiss P, Graves DT, Knowler WC, Kunzel C, et al. Diabetes and oral disease: implications for health professionals. Ann N Y Acad Sci 2012;1255:1-15. https://doi.org/10.1111/j.1749-6632.2011.06460.x
  8. Garton BJ, Ford PJ. Root caries and diabetes: risk assessing to improve oral and systemic health outcomes. Aust Dent J 2012;57(2):114-22. https://doi.org/10.1111/j.1834-7819.2012.01690.x
  9. Kogawa EM, Grisi DC, Falcao DP, Amorim IA, Rezende TM, da Silva IC, et al. Impact of glycemic control on oral health status in type 2 diabetes individuals and its association with salivary and plasma levels of chromogranin A. Arch Oral Biol 2016;62:10-9. https://doi.org/ 10.1016/j.archoralbio.2015.11.005
  10. Weinspach K, Staufenbiel I, Memenga-Nicksch S, Ernst S, Geurtsen W, Gunay H. Level of information about the relationship between diabetes mellitus and periodontitis-results from a nationwide diabetes information program. Eur J Med Res 2013;18:6. https://doi.org/10. 1186/2047-783X-18-6 https://doi.org/10.1186/2047-783X-18-6
  11. Newsholme P, Cruzat V, Arfuso F, Keane K. Nutrient regulation of insulin secretion and action (2014). J Endocrinol 2014;221(3):R105-20. https://doi.org/10.1530/JOE-13-0616
  12. Yun WJ, Shin MH, Kweon SS, Park KS, Lee YH, Nam HS, et al. A comparison of fasting glucose and HbA1c for the diagnosis of diabetes mellitus among Korean adults. J Prev Med Public Health 2010;43(5):451-4. https://doi.org/10.3961/jpmph.2010.43.5.451
  13. Kocher T, Konig J, Borgnakke WS, Pink C, Meisel P. Periodontal complications of hyperglycemia/diabetes mellitus: epidemiologic complexity and clinical challenge. Periodontol 2000 2018;78(1):59-97. https://doi.org/10.1111/prd.12235
  14. Gil-Montoya JA, de Mello AL, Barrios R, Gonzalez-Moles MA, Bravo M. Oral health in the elderly patient and its impact on general well-being: a nonsystematic review. Clin Interv Aging 2015;11:461-7. https://doi.org/10.2147/CIA.S54630
  15. Nadanovsky P, Dos Santos APP, Bloch KV. Prevalence of self-reported gingival bleeding in a representative sample of the Brazilian adolescent population. J Clin Periodontol 2018;45(8):952-8. https://doi.org/10.1111/jcpe.12959
  16. Gilbert GH, Duncan RP, Heft MW, Dolan TA, Vogel WB. Multidimensionality of oral health in dentate adults. Med Care 1998;36(7):988-1001. https://doi.org/10.1097/00005650-199807000-00006
  17. Dumitrescu AL, Kawamura M, Dogaru BC, Dogaru CD. Self-reported oral health status, oral health-related behaviours, resilience and hope in Romania. Oral Health Prev Dent 2009;7(3):251-9.
  18. Gilbert GH, Shelton BJ, Chavers LS, Bradford EH Jr. The paradox of dental need in a population-based study of dentate adults. Med Care 2003;41(1):119-34. https://doi.org/10.1097/00005650-200301000-00014
  19. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41(4):1149-60. https://doi.org/10.3758/BRM.41.4.1149
  20. Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol 2002;30(3):182-92. https://doi.org/10.1034/j.1600-0528.2002.300304.x
  21. Ng SK, Leung WK. Oral health-related quality of life and periodontal status. Community Dent Oral Epidemiol 2006;34(2):114-22. https://doi.org/10.1111/j.1600-0528.2006.00267.x
  22. Buset SL, Walter C, Friedmann A, Weiger R, Borgnakke WS, Zitzmann NU. Are periodontal diseases really silent? A systematic review of their effect on quality of life. J Clin Periodontol 2016;43(4):333-44. https://doi.org/10.1111/jcpe.12517
  23. Roy M, Gastaldi G, Courvoisier DS, Mombelli A, Giannopoulou C. Periodontal health in a cohort of subjects with type 1 diabetes mellitus. Clin Exp Dent Res 2019;5(3):243-9. https://doi.org/10.1002/cre2.178
  24. Leite RS, Marlow NM, Fernandes JK, Hermayer K. Oral health and type 2 diabetes. Am J Med Sci 2013;345(4):271-3. https://doi.org/10.1097/MAJ.0b013e31828bdedf
  25. Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol 2011;7(12):738-48. https://doi.org/10.1038/nrendo.2011.106
  26. Lakschevitz F, Aboodi G, Tenenbaum H, Glogauer M. Diabetes and periodontal diseases: interplay and links. Curr Diabetes Rev 2011;7(6):433-9. https://doi.org/10.2174/157339911797579205
  27. Bascones-Martinez A, Gonzalez-Febles J, Sanz-Esporrin J. Diabetes and periodontal disease: review of the literature. Am J Dent 2014;27(2):63-7.
  28. Wang S, Liu J, Zhang J, Lin J, Yang S, Yao J, et al. Glycemic control and adipokines after periodontal therapy in patients with Type 2 diabetes and chronic periodontitis. Braz Oral Res 2017;31:e90. https://doi.org/10.1590/1807-3107BOR-2017.vol31.0090
  29. Verhulst MJ, Teeuw WJ, Gerdes VE, Loos BG. Self-reported oral health and quality of life in patients with type 2 diabetes mellitus in primary care: a multi-center crosssectional study. Diabetes Metab Syndr Obes 2019;12:883-99. https://doi.org/10.2147/DMSO.S207087
  30. Birch S, Ismail AI. Patient preferences and the measurement of utilities in the evaluation of dental technologies. J Dent Res 2002;81(7):446-50. https://doi.org/10.1177/154405910208100702