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Epidemiology and Clinical Features of Coronavirus disease 2019 in Children

소아청소년 코로나바이러스감염증-19: 역학과 임상 양상

  • Choi, Soo-Han (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Han Wool (Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kang, Ji-Man (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) ;
  • Kim, Dong Hyun (Department of Pediatrics, Inha University Hospital, Inha University School of Medicine) ;
  • Cho, Eun Young (Department of Pediatrics, Chungnam National University Hospital)
  • 최수한 (한림대학교 의과대학 동탄성심병원 소아청소년과) ;
  • 김한울 (한림대학교 의과대학 한림대학교성심병원 소아청소년과) ;
  • 강지만 (세브란스 어린이병원, 연세대학교 의과대학 소아과학교실) ;
  • 김동현 (인하대학교 의과대학 부속병원 소아청소년과, 인하대학교 의과대학 소아과학교실) ;
  • 조은영 (충남대학교병원 소아청소년과)
  • Received : 2020.03.16
  • Accepted : 2020.04.01
  • Published : 2020.04.25

Abstract

Coronavirus disease 2019 (COVID-19), which started in Wuhan, China, in December 2019 and declared a worldwide pandemic on March 11, 2020, is a novel infectious disease that causes respiratory illness and death. Pediatric COVID-19 accounts for a small percentage of patients and is often milder than that in adults; however, it can progress to severe disease in some cases. Even neonates can suffer from COVID-19, and children may spread the disease in the community. This review summarizes what is currently known about COVID-19 in children and adolescents.

2019년 12월 발견되어 2020년 3월 11일 전 세계 대유행이 선포된 코로나바이러스감염증-2019 (coronavirus disease-2019, COVID-19)는 신종 감염병으로서 수많은 감염사례와 사망을 초래하여 사회 전반적으로 영향을 끼치고 있다. 소아청소년 COVID-19는 발병 환자 중 차지하는 비율이 적으며 성인보다는 경증인 경우가 많으나, 일부에서는 중증으로 진행할 수 있다. 신생아 시기부터 감염될 수 있으며, 지역사회 감염의 전파자로서 역할을 할 수 있을 것으로 보인다. 본 종설에서는 현재까지 소아청소년에서의 COVID-19에 대해 알려진 내용을 정리하여 소아청소년 환자들의 진료에 도움을 주고자 한다.

Keywords

References

  1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727-33. https://doi.org/10.1056/NEJMoa2001017
  2. World Health Organization. Novel coronavirus (2019-nCoV), situation report-22 [Internet]. Geneva: World Health Organization; 2020 [cited 2020 Mar 12]. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.pdf.
  3. World Health Organization. Coronavirus disease 2019 (COVID-19), situation report-51 [Internet]. Geneva: World Health Organization; 2020 [cited 2020 Mar 12]. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf.
  4. Kim JY, Choe PG, Oh Y, Oh KJ, Kim J, Park SJ, et al. The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures. J Korean Med Sci 2020;35:e61. https://doi.org/10.3346/jkms.2020.35.e61
  5. Korea Centers for Disease Control and Prevention. The updates of COVID-19 in Republic of Korea, as of 11 March, 2020. Cheongju: Korea Centers for Disease Control and Prevention; 2020.
  6. World Health Organization. Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19), 16-24 February 2020. Geneva: World Health Organization; 2020.
  7. Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020;395:514-23. https://doi.org/10.1016/s0140-6736(20)30154-9
  8. Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of COVID-19 in children in early January 2020 in Wuhan, China. N Engl J Med 2020;382:1370-1. https://doi.org/10.1056/NEJMc2003717
  9. Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics. J Formos Med Assoc 2020;119:670-3. https://doi.org/10.1016/j.jfma.2020.02.009
  10. Fang F, Luo XP. Facing the pandemic of 2019 novel coronavirus infections: the pediatric perspectives. Zhonghua Er Ke Za Zhi 2020;58:81-5.
  11. Society of Pediatrics, Chinese Medical Association; Editorial Board, Chinese Journal of Pediatrics. Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition). Zhonghua Er Ke Za Zhi 2020;58:169-74.
  12. Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis, in press 2020.
  13. Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi 2020;41:145-51.
  14. Wang D, Ju XL, Xie F, Lu Y, Li FY, Huang HH, et al. Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China. Zhonghua Er Ke Za Zhi 2020;58:E011.
  15. 3 coronavirus cases in Malaysia include 2-year-old boy. New Straits Times [Internet]. 2020 Jan 25 [cited 2020 Mar 12]. Available from: https://www.nst.com.my/news/nation/2020/01/559584/3-coronavirus-cases-malaysia-include-2-year-old-boy.
  16. Current information on the corona virus situation in Bavaria - Bavarian Ministry of Health: 8th case confirmed - 33-year-old man from Munich [Internet]. Bavarian State Ministry of Health and Care: Munich; 2020 Feb 1 [cited 2020 Mar 12]. Available from: https://www.stmgp.bayern.de/presse/aktuelle-informationen-zur-coronavirus-lage-in-bayern-bayerisches-gesundheitsministerium-8/.
  17. Singapore Government Agency. COVID-19: cases in Singapore [Internet]. Singapore: Singapore Government Agency; 2020 [cited 2020 Mar 12]. Available from: https://www.gov.sg/article/covid-19-cases-in-singapore.
  18. Kam KQ, Yung CF, Cui L, Lin Tzer Pin R, Mak TM, Maiwald M, et al. A well infant with coronavirus disease 2019 (COVID-19) with high viral load. Clin Infect Dis, in press 2020.
  19. Ministry of Health Vietnam. Situation of diseases, COVID-19, 11 Feb 2020 [Internet]. Hanoi: Ministry of Health Vietnam; 2020 [cited 2020 Mar 12]. Available from: https://ncov.moh.gov.vn/web/guest/dong-thoi-gian.
  20. Italian National Institute of Health. Integrated surveillance of COVID-19 in Italy, 09 Mar 2020 [Internet]. Rome: Italian National Institute of Health; 2020 [cited 2020 Mar 12]. Available from: https://www.iss.it/documents/20126/0/Infografica_09marzo.pdf/
  21. COVID-19 National Incident Room Surveillance Team. COVID-19, Australia: epidemiology report 6 (reporting week ending 19:00 AEDT 7 March 2020). Commun Dis Intell (2018) 2020;44:1-15.
  22. Park JY, Han MS, Park KU, Kim JY, Choi EH. First pediatric case of coronavirus disease 2019 in Korea. J Korean Med Sci 2020;35:e124. https://doi.org/10.3346/jkms.2020.35.e124
  23. Kim BG. 4-year-old becomes youngest COVID-19 patient. The Korea Herald [Internet]. 2020 Feb 23 [cited 2020 Mar 12]. Available from: http://www.koreaherald.com/view.php?ud=20200223000222.
  24. Joo KD. 45-day-old baby infected with new coronavirus in S. Korea: authorities. Yonhap News Agency [Internet]. 2020 Mar 1 [cited 2020 Mar 12]. Available from: https://en.yna.co.kr/view/AEN20200301001500320.
  25. 4 week old newborn baby was confirmed in Dongdaemun-gu, Seoul: probably the nation's youngest. Yonhap News Agency [Internet]. 2020 Mar 8 [cited 2020 Mar 12]. Available from: https://www.yna.co.kr/view/AKR20200308073500004.
  26. KOrean Statistical Information Service (KOSIS). Registered population by administrative district/year-old [Internet]. Daejeon: Statistics Korea; 2020 Feb [cited 2020 Mar 12]. Available from: http://kosis.kr/statHtml/statHtml.do?orgId=101&tblId=DT_1B04006&conn_path=I2.
  27. Korea Centers for Disease Control and Prevention. Pediatric COVID-19 patients in Korea. Cheongju: Korea Centers for Disease Control and Prevention; 2020. [unpublished data]
  28. Cai J, Xu J, Lin D, Yang Z, Xu L, Qu Z, et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis, in press 2020.
  29. Wei M, Yuan J, Liu Y, Fu T, Yu X, Zhang ZJ. Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA, in press 2020.
  30. Feng K, Yun YX, Wang XF, Yang GD, Zheng YJ, Lin CM, et al. Analysis of CT features of 15 children with 2019 novel coronavirus infection. Zhonghua Er Ke Za Zhi 2020;58:275-8.
  31. Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. Pediatr Pulmonol 2020;55:1169-74. https://doi.org/10.1002/ppul.24718
  32. Chen F, Liu ZS, Zhang FR, Xiong RH, Chen Y, Cheng XF, et al. First case of severe childhood novel coronavirus pneumonia in China. Zhonghua Er Ke Za Zhi 2020;58:179-82.
  33. Chen ZM, Fu JF, Shu Q, Chen YH, Hua CZ, Li FB, et al. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J Pediatr, in press 2020.
  34. Shen K, Yang Y, Wang T, Zhao D, Jiang Y, Jin R, et al. Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement. World J Pediatr, in press 2020.
  35. Zhang YH, Lin DJ, Xiao MF, Wang JC, Wei Y, Lei ZX, et al. 2019-novel coronavirus infection in a three-month-old baby. Zhonghua Er Ke Za Zhi 2020;58:182-4.
  36. Liu J, Liao X, Qian S, Yuan J, Wang F, Liu Y, et al. Community transmission of severe acute respiratory syndrome coronavirus 2, Shenzhen, China, 2020. Emerg Infect Dis, in press 2020.
  37. Benedetti TJ, Valle R, Ledger WJ. Antepartum pneumonia in pregnancy. Am J Obstet Gynecol 1982;144:413-7. https://doi.org/10.1016/0002-9378(82)90246-0
  38. Berkowitz K, LaSala A. Risk factors associated with the increasing prevalence of pneumonia during pregnancy. Am J Obstet Gynecol 1990;163:981-5. https://doi.org/10.1016/0002-9378(90)91109-p
  39. Madinger NE, Greenspoon JS, Ellrodt AG. Pneumonia during pregnancy: has modern technology improved maternal and fetal outcome? Am J Obstet Gynecol 1989;161:657-62. https://doi.org/10.1016/0002-9378(89)90373-6
  40. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020;395:809-15. https://doi.org/10.1016/s0140-6736(20)30360-3
  41. Wang X, Zhou Z, Zhang J, Zhu F, Tang Y, Shen X. A case of 2019 novel coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis, in press 2020.
  42. Liu Y, Chen H, Tang K, Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect, in press 2020.
  43. Li Y, Zhao R, Zheng S, Chen X, Wang J, Sheng X, et al. Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China. Emerg Infect Dis, in press 2020.
  44. Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr 2020;9:51-60. https://doi.org/10.21037/tp.2020.02.06
  45. Zeng LK, Tao XW, Yuan WH, Wang J, Liu X, Liu ZS. First case of neonate with COVID-19 in China. Zhonghua Er Ke Za Zhi 2020;58:279-80.

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