DOI QR코드

DOI QR Code

항암화학요법과 통합의학치료를 병행하여 부분 관해 된 간전이 동반 말기 췌장암 1례

A Case Report of Partial Remission of End-stage Pancreatic Cancer Patient with Liver Metastasis Treated with Chemotherapy and Integrated Medicine Therapy

  • 투고 : 2020.03.20
  • 심사 : 2020.05.21
  • 발행 : 2020.05.30

초록

Objectives: This study reports on the effect of Integrative Medicine Therapy (IMT) on a patient with pancreatic cancer with liver metastasis. Methods: One pancreatic cancer with liver metastasis patient was treated using IMT in conjunction with Gemcitabine/Abraxane since September 2019. The cycle was repeated every four weeks for a total of 11 times. At the same time, the patient was treated with IMT. Tumor size was measured by scanning with Computed Tomography (CT). Adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0. Results: After treatment with Gemcitabine/Abraxane and IMT for eight months, the size of the body and tail of the cancer tumor and several hepatic metastatic regions decreased (partial response, [PR]), size, and number of multiple nodules in both lungs decreased. No evidence of newly developed metastatic lesions was found. The patient has maintained a good treatment outcome and has shown prolonged overall survival. Conclusions: This case demonstrates that treatment with IMT may have substantial benefits for patients with end-stage pancreatic cancer.

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참고문헌

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics 2018. CA Cancer J Clin 2018;68(1):7-30. https://doi.org/10.3322/caac.21442
  2. National Center Information Cancer. Goyang-si, Republic of Korea: Ministry of Health and Welfare; [cited 2019 Feb 20]. Available from: URL: https://www.cancer.go.kr
  3. JK Park, Yoon YB, Kim YT, Ryu JK, Lee JK, Yoon WJ, et al. Survival and prognostic factors of unresectable pancreatic cancer. The Korean Journal of Medicine 2007;72(2):151-61.
  4. Kleeff J, Korc M, Apte M, Vecchia CL, Johnson CD, Biankin AV, et al. Pancreatic cancer. Nature Reviews 2016;2:16023.
  5. Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, et al. Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine. N Engl J Med 2013;369(18):1691-703. https://doi.org/10.1056/NEJMoa1304369
  6. Reyes-Gibby CC, Chan W, Abbruzzese JL, Xiong HQ, Ho L, Evans DB, et al. Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation. J Pain Symptom Manage 2007;34(3):244-52. https://doi.org/10.1016/j.jpainsymman.2006.11.007
  7. Renia M, Bonettoa E, Cordio S, Passoni P, Carlo Milandri C, Cereda S, et al. Quality of life assessment in advanced pancreatic adenocarcinoma: results from a Phase III randomized trial. Pancreatology 2006;6(5):454-63. https://doi.org/10.1159/000094563
  8. Chang SH, Park JH, Yoo HS. A Case Report of Partial Remission of Renal Cell Carcinoma with Multiple Liver Metastases Treated with Korean Herbal Medicine in Conjunction with Targeted Anticancer Therapy Afinitor. J of Kor Traditional Oncology 2017;22(2):13-24. https://doi.org/10.15432/JKTO.2017.22.2.013
  9. Jin YJ, Shin KS, Ha JY. A Case of Improvement of Metastatic Ovarian and Endometrial Cancer Treated by Integrative Medicine Therapy Combined with Chemotherapy. J of Kor Traditional Oncology 2014;19(1):33-41. https://doi.org/10.15432/JKTO.2014.19.1.33
  10. Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R. New response evaluation criteria in solid tumours: Revised RECIST guideline(version 1.1). Eur J Cancer 2009;45(2):228-47. https://doi.org/10.1016/j.ejca.2008.10.026
  11. National Cancer Institute. Common Terminology Criteria for Adverse Events(CTCAE) v.5.0, 2017. Available from : URL: https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_5.0/
  12. Sharma S. Tumor markers in clinical practice: General principles and guidelines. Indian journal of medical and paediatric oncology. official journal of Indian Society of Medical & Paediatric Oncology 2009;30(1):1-8. https://doi.org/10.4103/0971-5851.56328
  13. National Comprehensive Cancer Network [internet]. Plymouth Meeting, USA : National Comprehensive Cancer Network ; [cited 2019 Jan 20]. Available from: URL : https://www.nccn.org/professionals/physician_gls/pdf/pancreatic.pdf
  14. Cho YD. Supportive care for symptom relief in pancreatic cancer. Korean J Gastroenterology 2008;51(2):119-26.
  15. Lockhart AC, Rothenberg ML, Berlin JD. Treatment for pancreatic cancer: current therapy and continued progress. Gastroenterology 2005;128(6):1642-54. https://doi.org/10.1053/j.gastro.2005.03.039
  16. Schmitz KH, Courneya KS, Matthews C, Demark Wahnefried W, Galvao DA, Pinto BM, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 2010;42(7):1409-26. https://doi.org/10.1249/MSS.0b013e3181e0c112
  17. Li M, Wang MM, Guo XW, Wu CY, Li DR, Zhang X, et al. Different Survival Benefits of Chinese Medicine for Pancreatic Cancer : How to Choose? Chin J Integr Med 2018;24(3):178-84. https://doi.org/10.1007/s11655-017-2971-1
  18. 김진목. 통합암치료 로드맵. 경기도 고양시: 서현사; 2014, p. 47, 50, 115.
  19. Levy MH, Adolph MD, Back A, Block S, Codada SN, Dalal S, et al. Palliative care. J Natl Compr Can c Netw 2012;10(10):1284-309. https://doi.org/10.6004/jnccn.2012.0132
  20. Smith TJ, Temin S, Alesi ER, Abernethy AP, Balboni TA, Basch EM, et al. American Society of Clinical Oncology Provisional Clinical Opinion : the integration of palliative care in to standard oncology care. J Clin Oncol 2012;30(8):880-7. https://doi.org/10.1200/JCO.2011.38.5161
  21. Herbology Editorial Committee of Nationwide College of Korean Medicine. Boncho-hak. Seoul: Younglimsa; 1991, p. 439.
  22. Jang HJ. Molecular mechanism by which Resina Toxicodendrii induces apoptosis and suppresses chemoresistance in MCF-7/DOX cells. Graduate School of Korean Medicine, Kyunghee University 2017:16.
  23. Park SJ, Kang HJ, Park JH, Cho CK, Yoo HS. A case report of a clinically diagnosed advanced lung cancer patient after treatment with Gunchil gyebok-Jung. J of Kor Traditional Oncology 2015;20(1):23-9. https://doi.org/10.15432/JKTO.2015.20.1.023
  24. Han GJ, Lee AR, Jung JS, Seong S, Kim SS. A Case Study of a Patient with Breast Cancer Treated with a Combination of Traditional Korean Medicine and Chemotherapy. J Int Korean Med 2017;38(5):820-7. https://doi.org/10.22246/jikm.2017.38.5.820
  25. Wong R, Sagar S. Acupuncture treatment for chemotherapy-induced peripheral neuropathy--a case series. Acupuncture in medicine. Journal of the British Medical Acupuncture Society 2006;24(2):87-91. https://doi.org/10.1136/aim.24.2.87
  26. Bao T, Zhang R, Badros A. Lao L. Acupuncture treatment for bortezomib-induced peripheral neuropathy: a case report. Pain research and treatment 2011;2011:1-4.
  27. Viscum album[L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: A randomised clinical trial on overall survival. European Journal of Cancer 2013;49(18):3788-97. https://doi.org/10.1016/j.ejca.2013.06.043
  28. Rasi G, Silecchia G, Sinibaldi-Vallebona P. Anti-tumor effect of combined treatment with thymosin alpha 1 and interleukin-2 after 5-fluorouracil in liver metastases from colorectal cancer in rats. International Jounal of Cancer 1994;57(5):701-5. https://doi.org/10.1002/ijc.2910570516
  29. Mastino A, Favalli C, Grelli S. Combonation therapy with thymosin alpha 1 potentiastes the antitumor activity of interleukin-2 with cyclophosphamide in the treatment of the Lewis Lung carcinoma in mice. International Journal of Cancer 1992;50(3):493-9. https://doi.org/10.1002/ijc.2910500327
  30. Sharif-Khatibi L, Kariminia A, Khoei S, Goliaei B. Hyperthermia induces differentiation without apoptosis in permissive temperatures in human erythroleukaemia cells. Int J Hyperthermia 2007 Dec;23(8):645-55. https://doi.org/10.1080/02656730701769833
  31. Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol 2002;3(8):487-97. https://doi.org/10.1016/S1470-2045(02)00818-5
  32. Review of Domestic Research on Korean Medicine for Pancreatic Cancer. J Int Korean Med 2019;40(1):70-88.
  33. Chang SH, Park JH, Yoo HS. A Case Report of Partial Remission of Renal Cell Carcinoma with Multiple Liver Metastases Treated with Korean Herbal Medicine in Conjunction with Targeted Anticancer Therapy Afinitor J of Kor Traditional Oncology 2017;22(2):13-24. https://doi.org/10.15432/JKTO.2017.22.2.013