Journal of Korean society of Dental Hygiene (한국치위생학회지)

Korean Society of Dental Hygiene (한국치위생학회)
권호 표지
DOI QR코드

DOI QR Code

Association between periodontal disease, number of remaining teeth and high-sensitivity C-reactive protein in Korean adults aged 40 and older: Based on data from 2015 Korea National Health and Nutrition Examination Survey

한국 40세 이상 성인의 치주질환, 잔존 치아 수와 고감도 C-반응성 단백의 연관성: 2015 국민건강영양조사 제6기 자료

  • 조윤영 (수원여자대학교 치위생과)
  • Received : 2020.02.24
  • Accepted : 2020.04.11
  • Published : 2020.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The purpose of this study was to investigate the relationship between periodontal disease, number of remaining teeth with high-sensitivity C-Reactive protein in Korean adults aged 40 and older. Methods: The study used the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3), 2015. The study sample consisted of 3,883 aged 40 years or older who had completed the health survey and the health examination. Logistic regression analyses were performed to examine the odds ratios of high-sensitivity C-Reactive protein by periodontal disease and number of remaining teeth, adjusting for demographic characteristics, chronic diseases and oral health behavior-related variables. Results: When the demographic and chronic diseases were adjusted, the risk of high-sensitivity C-Reactive protein (hs-CRP) average 1.23 mg/L or higher was 1.36 times higher in patients with periodontal disease between the ages of 40 and 49, but it was not significant (OR=1.36; 95% CI=0.82-2.23). In addition, in the group of 0~23 remaining teeth aged 40~49 years, the risk of higher than the average 1.23 mg/L of high-sensitivity C-Reactive protein was 2.03 times higher (OR=2.03; 95% CI=1.10-3.74), and 1.49 times higher in 60~69 years (OR=1.07; 95% CI=1.04-2.76). Conclusions: This study found that periodontal disease and tooth loss in Korean adults aged 40 and older was significantly associated with high-sensitivity C-reactive protein.

Keywords

References

  1. World Health Organization. Noncommunicable diseases country profiles 2011. Geneva: World Health Organization; 2011: 5.
  2. Korea Centers for Disease Control and Prevention. 2018 Chronic disease status and issues. Republic of Korea: Korea Centers for Disease Control and Prevention; 2018: 6.
  3. Korean Statistical Information Service. Disease classification Frequency Sickness Benefit Status[Internet]. Korean Statistical Information Service.[cited 2019 Feb 01]. Available from: http://kosis.kr/statHtml/statHtml.do?orgId=350&tblId=DT_35001_A073112&vw_cd=MT_ZTITLE&list_id=350_35001_6&seqNo=&lang_mode=ko&language=kor&obj_var_id=&itm_id=&conn_path=MT_ZTITLE.
  4. Beck JD, Pankow J, Tyroler HA, Ofenhacher S. Dental infections and atherosclerosis. Am Heart J 1999;138(5):528-33. https://doi.org/10.1016/S0002-8703(99)70293-0
  5. Paul IE. Periodontal disease is associated with increased risk of future cardiovascular diseases. J Evidence Based Dental Practice 2004;4(2):160-2. https://doi.org/10.1016/j.jebdp.2004.03.016
  6. Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: An epidemiologic perspective. Ann Periodontol 2001;6(1):99-112. https://doi.org/10.1902/annals.2001.6.1.99
  7. Nagasawa T, Noda M, Katagiri S, Takaichi M, Takahashi Y, Wara-Aswapati N, et al. Relationship between periodontitis and diabetes-importance of a clinical study to prove the vicious cycle. Intern Med 2010;49(10):881-5. https://doi.org/10.2169/internalmedicine.49.3351
  8. Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB. Production of C-reactive protein and risk of coronary events in stable and unstable angina. European concerted action on thrombosis and disabilities angina pectoris study group. Lancet 1997;349:462-6. https://doi.org/10.1016/S0140-6736(96)07591-5
  9. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the centers for disease control and prevention and the american heart association. Circulation 2003;107(3):499-511. https://doi.org/10.1161/01.cir.0000052939.59093.45
  10. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001;103(13):1813-8. https://doi.org/10.1161/01.cir.103.13.1813
  11. Lee SY, Im AJ, Burm EA, Ha MN. Association between periodontitis and blood lipid levels in a Korean population. J Periodontol 2018;89:28-35. https://doi.org/10.1902/jop.2017.170111.
  12. Choi JS. Association between periodontitis and hypertriglyceridemia in Korean adults aged 30 and older : based on data from 2015 Korea national health and nutrition examination survey. J Korean Soc Dent Hyg 2020;20(1):53-62. https://doi.org/10.13065/jksdh.20200006
  13. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001;72(9):1221-7. https://doi.org/10.1902/jop.2000.72.9.1221
  14. Son SH, Lee ES. Relationship between periodontal disease and level of high-sensitivity C reactive protein in Korean adults. J Korean Soc Dent Hyg 2019;19(6):919-29. htps://doi.org/10.13065jksdh.20190078
  15. Korea Center for Disease Control and Prevention. The Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3), 2015. Republic of Korea: Korea Center for Disease Control and Prevention.
  16. Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG. The alcohol use disorders identification test:guidelines for use in primary care (second edition). World Health Organization; 2001: 15-20.
  17. Lee SY, Park HS, Kim SM, Kwon HS, Kim DY, Kim DJ, et al. Cut-off points of waist circumference for defining abdominal obesity in the Korean population. J Obes Metab Syndr 2006;15(1):1-9.
  18. Won YS, Choi CH, Oh HN. Risk factors of periodontal disease in Korean adults. J Korean Acad Oral Health 2014;38(3):176-83. https://doi.org/10.11149/jkaoh.2014.38.3.176
  19. Lee SM, Kim KY, Kim J. Analysis of the relationship between systemic health status and periodontal disease in Korean adults -survey study of the fifth Korea national health and nutrition examination. Korean J Oral Maxillofac Pathol 2015;39(2):447-56. https://doi.org/10.17779/KAOMP.2015.39.2.447
  20. Lee YH, Choi JO. Convergence of relationship between obesity and periodontal disease in adults. Journal of the Korea Convergence Society 2017;8:215-22. https://doi.org/10.15207/JKCS.2017.8.11.215
  21. Anand SS, Razak F, Yi Q, Davis B, Jacobs R, Vuksan V, et al. C-reactive protein as a screening test for cardiovascular risk in a multiethnic population. Arterioscler Thromb Vasc Biol 2004;24:1509-15. https://doi.org/10.1161/01.ATV.0000135845.95890.4e
  22. Lee SJ. Relationship of oral health-related behaviors to high-sensitivity CRP: Data from the sixth (2015) Korea national health and nutrition examination survey. J Health Info Stat 2018;43(1):64-9. https://doi.org/10.21032/jhis.2018.43.1.64
  23. Kim SK, Park JA, Ham SK, Shin MW, Yu EH, Sohn YH. The relation of high-sensitivity C-reactive protein with metabolic syndrome in Korean adults: Based on the Korean health and nutrition examination survey, 2015. Korean J Fam Pract 2018;8(5):684-9. https://doi.org/10.21215/kjfp.2018.8.5.684
  24. Sung KC, Kang JH. Serum C-reactive protein level and its association with H. pylori infection and other risk factors in apparently healthy Korean. Korean Circulation J 2002;32(7):573-80. https://doi.org/10.4070/kcj.2002.32.7.573
  25. Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000;71(10):1528-34.https://doi.org/10.1902/jop.2000.71.10.1528
  26. Lee KO, Youn HS. Relationship between inequalities in health and inequalities in socioeconomic status. J Korean Acad Community Health Nurs 2001;12(3):609-19.
  27. Lee NY, Han MO, Cho HJ, Park HS. Relationship between obesity, lifestyle and demographic factors and CRP. Korean Society for the Study of Obesity 2004;13(2):141-9.
  28. Morohoshi M, Fujisawa K, Uchimura I, Numano F. Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro. Diabetes 1996;45(7):954-9. https://doi.org/10.2337/diabetes.45.7.954
  29. Ylostalo PV, Jarvelin MR, Laitinen J, Knuuttila ML. Self-reported gingivitis and tooth loss poorly predict C-reactive protein levels: a study among Finnish young adults. J Clin Periodontol 2008;35(2):114-9. https://doi.org/10.1111/j.1600-051X.2007.01175.x
  30. Jung JH. A study of association between marginal alveolar bone loss tooth and C-reactive protein[Master's thesis]. Seoul: Univ. of Korea, 2010.