Journal of the Korea Society of Computer and Information (한국컴퓨터정보학회논문지)

Korean Society of Computer Information (한국컴퓨터정보학회)
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A Bio-Edutainment System to Virus-Vaccine Discovery based on Collaborative Molecular in Real-Time with VR

  • Received : 2020.05.21
  • Accepted : 2020.06.09
  • Published : 2020.06.30
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Abstract

An edutainment system aims to help learners to recognize problems effectively, grasp and classify important information needed to solve the problems and convey the contents of what they have learned. Edutainment contents can be usefully applied to education and training in the both scientific and industrial areas. Our present work proposes an edutainment system that can be applied to a drug discovery process including virtual screening by using intuitive multi-modal interfaces. In this system, a stereoscopic monitor is used to make three-dimensional (3D) macro-molecular images, with supporting multi-modal interfaces to manipulate 3D models of molecular structures effectively. In this paper, our system can easily solve a docking simulation function, which is one of important virtual drug screening methods, by applying gaming factors. The level-up concept is implemented to realize a bio-game approach, in which the gaming factor depends on number of objects and users. The quality of the proposed system is evaluated with performance comparison in terms of a finishing time of a drug docking process to screen new inhibitors against target proteins of human immunodeficiency virus (HIV) in an e-drug discovery process.

에듀테인먼트 시스템은 학습자가 문제를 효과적으로 인식하고, 문제를 해결하는 데 필요한 중요한 정보를 파악 분류하고, 배운 내용을 전달할 수 있도록 돕는 것을 목표로 한다. 에듀테인먼트를 활용한 콘텐츠는 과학 및 산업 분야의 교육 및 훈련에 유용하게 적용될 수 있다. 본 논문에서는 직관적인 멀티 모달 인터페이스를 활용하여 신약개발에서 활용되고 있는 가상스크리닝에 적용될 수 있는 에듀테인먼트 시스템을 제안한다. 본 연구에서는 분자 구조의 3D 모델을 효과적으로 조작하기 위해 입체 모니터를 활용하여 3차원(3D)거대 분자 모델링을 시각화 하였으며, 멀티 모달 인터페이스를 활용하여 분자 모델을 조작하고 있다. 본 시스템은 신약 개발 혹은 백신 개발에 있어 매우 중요한 방법 중의 하나인 가상 약물 선별 방법 중 하나 인 도킹 시뮬레이션 실험을 게임적 요소를 활용하여 쉽게 해결하는 방법을 제안하고 있다. 레벨 업 개념은 게임 요소가 객체와 사용자의 수에 의해 의존되는 바이오 게임 접근법을 활용하여 구현하였다. 실험 방법으로는 제안된 시스템의 신약 개발 과정에서 인간 면역 결핍 바이러스 (HIV)의 새로운 후보물질을 활용하여 바이러스의 활동 억제를 스크리닝하는 도킹 과정에서의 시간 측정으로 성능 비교 평가하였다.

Keywords

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