DOI QR코드

DOI QR Code

Monitoring of Biogenic Amines Content in Commercial Fermented Alcoholic Beverages in Gangwon-do and Risk Assessment

강원도 유통 발효주 중 바이오제닉 아민류 함량 조사 및 위해도 평가

  • 배철민 (강원도보건환경연구원) ;
  • 신인철 (강원도보건환경연구원) ;
  • 이완 (강원도보건환경연구원) ;
  • 이혁화 (강원도보건환경연구원) ;
  • 최여은 (강원도보건환경연구원) ;
  • 김영주 (강원도보건환경연구원) ;
  • 이가희 (강원도보건환경연구원) ;
  • 정경진 (강원도보건환경연구원) ;
  • 최승봉 (강원도보건환경연구원)
  • Received : 2020.06.01
  • Accepted : 2020.06.15
  • Published : 2020.06.30

Abstract

Objectives: This study was conducted to estimate the related health risk by investigating the content of biogenic amines (BAs) in commercial fermented alcoholic beverages. Methods: Ninety-seven samples, including takjus (34), fruit wines (26), distilled liquors (20) and beers (17) were purchased in Gangwon-do (Province) in 2019. The eight BAs (putrescine, cadaverine, spermine, spermidine, tyramine, β-phenylethylamine, histamine, and tryptamine) were analyzed by high performance liquid chromatograph (HPLC) after extraction (0.4 M HClO4), pigment removal (carbon cartridge) and derivatization (1% dansylchloride). The health risk of exposure to BAs due to ingestion of commercial fermented alcoholic beverages was estimated as the margin of exposure (MOE). Results: Various BAs were detected in takju, fruit wine, distilled liquor and beer. Putrescine (not detected (ND)-12.60 mg/L), cadaverine (ND-5.45 mg/L), tyramine (ND-8.34 mg/L), β-phenylethylamine (ND-13.73 mg/L), histamine (ND-7.96 mg/L), and tryptamine (ND-19.00 mg/L) were found in takju. Putrescine (ND-15.34 mg/L), cadaverine (ND-7.90 mg/L), β-phenylethylamine (ND-3.06 mg/L), histamine (ND-9.68 mg/L), and tryptamine (ND-14.06 mg/L) were identified in fruit wine. Putrescine (less than limit of detection (

Keywords

References

  1. EFSA Panel on Biological Hazards (BIOHAZ). Scientific opinion on risk based control of biogenic amine formation in fermented foods. EFSA Journal. 2011; 9(10): 2393. https://doi.org/10.2903/j.efsa.2011.2393
  2. Dong H, Xiao K. Modified QuEChERS combined with ultra high performance liquid chromatography tandem mass spectrometry to determine seven biogenic amines in Chinese traditional condiment soy sauce. Food Chemistry. 2017; 229: 502-508. https://doi.org/10.1016/j.foodchem.2017.02.120
  3. Silla Santos MH. Biogenic amines: their importance in foods. International Journal of Food Microbiology. 1996; 29(2-3): 213-231. https://doi.org/10.1016/0168-1605(95)00032-1
  4. Biji, KB, Ravishankar CN, Venkateswarlu R, Mohan CO, Gopal TKS. Biogenic amines in seafood:a review. Journal of Food Science and Technology. 2016; 53(5): 2210-2218. https://doi.org/10.1007/s13197-016-2224-x
  5. Shalaby AR. Significance of biogenic amines to food safety and human health. Food Research International. 1996; 29(7): 675-690. https://doi.org/10.1016/S0963-9969(96)00066-X
  6. Onal A. A review: Current analytical methods for the determination of biogenic amines in foods. Food Chemistry. 2007; 103(4): 1475-1486. https://doi.org/10.1016/j.foodchem.2006.08.028
  7. Wang YQ, Ye DQ, Zhu BQ, Wu GF, Duan CQ. Rapid HPLC analysis of amino acids and biogenic amines in wines during fermentation and evaluation of matrix effect. Food Chemistry. 2014; 163: 6-15. https://doi.org/10.1016/j.foodchem.2014.04.064
  8. Ordonez JL, Troncoso AM, Garcia-Parrilla MDC, Callejon RM. Recent trends in the determination of biogenic amines in fermented beverages-A review. Analytica Chimica Acta. 2016; 939: 10-25. https://doi.org/10.1016/j.aca.2016.07.045
  9. Mo Dugo G, Vilasi F, La Torre GL, Pellicano TM. Reverse phase HPLC/DAD determination of biogenic amines as dansyl derivatives in experimental red wines. Food Chemistry. 2006; 95(4): 672-676. https://doi.org/10.1016/j.foodchem.2005.07.001
  10. Korea Agro-Fisheries and Food Trade Corporation. 2015 Status of processed food segment marketliquor market. Naju: 2016. p.65-83.
  11. Martuscelli M, Arfelli G, Manetta AC, Suzzi G. Biogenic amines content as a measure of the quality of wines of Abruzzo (Italy). Food Chemistry. 2013; 140(3): 590-597. https://doi.org/10.1016/j.foodchem.2013.01.008
  12. Leitao MC, Marques AP, San Romao MV. A survey of biogenic amines in commercial Portuguese wines. Food Control. 2005; 16(3): 199-204. https://doi.org/10.1016/j.foodcont.2004.01.012
  13. Anli RE, Vural N, Yilmaz S, Vural YH. The determination of biogenic amines in Turkish red wines. Journal of Food Composition and Analysis. 2004;17(1): 53-62. https://doi.org/10.1016/S0889-1575(03)00104-2
  14. Pineda A, Carrasco J, Pena Farfal C, Henriquez Aedo K, Aranda M. Preliminary evaluation of biogenic amines content in Chilean young varietal wines by HPLC. Food Control. 2012; 23(1): 251-257. https://doi.org/10.1016/j.foodcont.2011.07.025
  15. Prete VD, Costantini A, Cecchini F, Morassut M, Garcia Moruno E. Occurrence of biogenic amines in wine: The role of grapes. Food Chemistry. 2009;112(2): 474-481. https://doi.org/10.1016/j.foodchem.2008.05.102
  16. Marques AP, Leitao MC, San Romao MV. Biogenic amines in wines: Influence of oenological factors. Food Chemistry. 2008; 107(2): 853-860. https://doi.org/10.1016/j.foodchem.2007.09.004
  17. Gloria MBA, Izquierdo Pulido M. Levels and significance of biogenic amines in Brazilian beers. Journal of Food Composition and Analysis. 1999;12(2): 129-136. https://doi.org/10.1006/jfca.1999.0817
  18. Kalac P, Savel J, Krizek M, Pelikanova T, Prokopova M. Biogenic amine formation in bottled beer. Food Chemistry. 2002; 79(4): 431-434. https://doi.org/10.1016/S0308-8146(02)00193-0
  19. Loret S, Deloyer P, Dandrifosse G. Levels of biogenic amines as a measure of the quality of the beer fermentation process: Data from Belgian samples. Food Chemistry. 2005; 89(4): 519-525. https://doi.org/10.1016/j.foodchem.2004.03.010
  20. Cho TY, Han GH, Bahn KN, Son YW, Jang MR, Lee CH, et al. Evaluation of biogenic amines in Korean commercial fermented foods. Korean Journal of Food Science and Technology, 2006; 38(6):730-737.
  21. Nam HW, Lee KW, Myung CO, Rhee JS, Lee YC, Hong CS. Analysis on the contents of histamine in Korean foods. Korean Journal of Food and Cookery Science. 1996; 12(4): 487-492.
  22. Korea institute of food and drug safety evaluation. Guide to harmful substance analysis for total dietary study, Cheongju: 2017. p.157-187.
  23. Busto O, Miracle M, Guasch J, Borrull F. Determination of biogenic amines in wines by high-performance liquid chromatography with on-column fluorescence derivatization. Journal of Chromatography A. 1997; 757(1-2): 311-318. https://doi.org/10.1016/S0021-9673(96)00693-0
  24. Korea institute of food and drug safety evaluation. Standardization guidelines for food consumption calculation and pollution monitoring, Cheongju:2018.
  25. European Food Safety Authority (EFSA). Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA Journal. 2005; 3(10): 282. https://doi.org/10.2903/j.efsa.2005.282
  26. FAO. On estimating the risk of developing histamine poisoning from the consumption Thai fish sauces. Available: http://www.fao.org/tempref/codex/Meetings/CCFFP/ccffp31/CRD/CRD_18_Thailand.pdf (accessed 4 October 2019).
  27. Korea institute of food and drug safety evaluation. Common guidelines for risk assessment of human applied products. Cheongju: 2019.
  28. Simat V, Dalgaard P. Use of small diameter column particles to enhance HPLC determination of histamine and other biogenic amines in seafood. LWT-Food Science and Technology. 2011; 44(2):399-406. https://doi.org/10.1016/j.lwt.2010.08.011
  29. Preti R, Antonelli ML, Bernacchia R, Vinci G. Fast determination of biogenic amines in beverages by a core-shell particle column. Food Chemistry. 2015;187: 555-562. https://doi.org/10.1016/j.foodchem.2015.04.075
  30. Papageorgiou M, Lambropoulou D, Morrison C, Klodzinska E, Namiesnik J, Plotka-Wasylka J. Literature update of analytical methods for biogenic amines determination in food and beverages. Trends in Analytical Chemistry. 2018; 98: 128-142. https://doi.org/10.1016/j.trac.2017.11.001
  31. Comuzzo P, Rauhut D, Werner M, Lagazio C, Zironi R. A survey on wines from organic viticulture from different European countries. Food Control. 2013; 34(2): 274-282. https://doi.org/10.1016/j.foodcont.2013.04.039
  32. Korea institute of food and drug safety evaluation. Risk Assessment of Biogenic Amines. Cheongju:2016.