Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit

  • Almansoori, Akram Abdo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Khentii, Namuun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Ju, Kyung Won (Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital) ;
  • Kim, Bongju (Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital) ;
  • Kim, Soung Min (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
  • Received : 2019.10.07
  • Accepted : 2019.12.17
  • Published : 2020.06.30
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Abstract

Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation. Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group) as follows: allograft rejection control (Allo-Ctrl), low dose (0.08 mg/kg) of FK506 (FK506-L), and high dose (0.16 mg/kg) of FK506 (FK506-H). Allograft survival and rejection were assessed by clinical observation, interleukin-2 levels as determined by enzyme-linked immunosorbent assay, blood sampling for complete blood count (CBC), and histological evaluation. Results: Body weight and anorexia were higher in the FK506-H group but without a significant difference compared with the FK506-L population. CBC revealed a non-significantly reduced number of changes in the FK506-L group. Four glands in the FK506-H group and two glands in the FK506- L group were viable and functioning post-transplantation. Conclusion: The survival rate of allotransplanted glands was higher in conjunction with the high dose of 0.16 mg/kg of FK506, with no major difference in the side-effect profile when compared with the low dose of 0.08 mg/kg short-term outcomes.

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References

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