Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants

  • Baldassarre, Maria Elisabetta (Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari) ;
  • Di Mauro, Antonio (Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari) ;
  • Salvatore, Silvia (Unit of Pediatrics and Neonatology, "F. Del Ponte" Hospital, Dipartimento di Medicina e Chirurgia University of Insubria) ;
  • Tafuri, Silvio (Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari) ;
  • Bianchi, Francesco Paolo (Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari) ;
  • Dattoli, Enzo (Unit of Pediatrics and Neonatology, "F. Del Ponte" Hospital, Dipartimento di Medicina e Chirurgia University of Insubria) ;
  • Morando, Lucia (Unit of Pediatrics and Neonatology, "F. Del Ponte" Hospital, Dipartimento di Medicina e Chirurgia University of Insubria) ;
  • Pensabene, Licia (Department of Medical and Surgical Sciences, Pediatric Unit, University "Magna Graecia" of Catanzaro) ;
  • Meneghin, Fabio (Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan) ;
  • Dilillo, Dario (Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan) ;
  • Mancini, Valentina (Pediatric Unit, Saronno Hospital) ;
  • Talarico, Valentina (Department of Medical and Surgical Sciences, Pediatric Unit, University "Magna Graecia" of Catanzaro) ;
  • Tandoi, Francesco (Unit of Pediatrics and Neonatology, "F. Del Ponte" Hospital, Dipartimento di Medicina e Chirurgia University of Insubria) ;
  • Zuccotti, Gianvincenzo (Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan) ;
  • Agosti, Massimo (Unit of Pediatrics and Neonatology, "F. Del Ponte" Hospital, Dipartimento di Medicina e Chirurgia University of Insubria) ;
  • Laforgia, Nicola (Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari)
  • Received : 2020.02.15
  • Accepted : 2020.04.21
  • Published : 2020.07.15
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Abstract

Purpose: To assess the association between birth weight and the development of functional gastrointestinal disorders (FGIDs) in the first year of life. Methods: This is a secondary analysis of a prospective cohort multicenter study including neonates, consecutively enrolled at birth, and followed up for one year. At birth all infants were classified by birth weight as extremely low (ELBW), very low, or low when <1,000, <1,500, and <2,500 g, respectively, and by birth weight for gestational age as appropriate (AGA, weight in the 10-90th percentile), small (SGA, weight <10th percentile), and large (LGA, weight >90th percentile) for gestational age. FGIDs were classified according to the Rome III criteria and assessed at 1, 3, 6, and 12 months of life. Results: Among 1,152 newborns enrolled, 934 (81.1%) completed the study: 302 (32.3%) were preterm, 35 (3.7%) were ELBW, 104 (11.1%) were SGA, 782 (83.7%) were AGA, and 48 (5.1%) were LGA infants. Overall, throughout the first year of life, 718 (76.9%) reported at least one FGID. The proportion of infants presenting with at least one FGID was significantly higher in ELBW (97%) compared to LBW (74%) (p=0.01) and in LGA (85.4%) and SGA (85.6%) compared to AGA (75.2%) (p=0.0001). On multivariate analysis, SGA was significantly associated with infantile colic. Conclusion: We observed an increased risk of FGIDs in ELBW, SGA, and LGA neonates. Our results suggest that prenatal factors determining birth weight may influence the development of FGIDs in infants. Understanding the role of all potential risk factors may provide new insights and targeted approaches for FGIDs.

Keywords

References

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