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A Literature Survey of Machine Learning Based Obstructive Sleep Apnea Diagnosis Research

  • Kim, Seo-Young (School of Computer Science and Engineering, Kyungpook National University) ;
  • Suh, Young-Kyoon (School of Computer Science and Engineering, Kyungpook National University)
  • Received : 2020.04.22
  • Accepted : 2020.06.19
  • Published : 2020.07.31

Abstract

Obstructive sleep apnea (OSA) among sleep disorders is one of relatively common diseases. Patients can be checked for the disease through sleep polysomnography. However, as far as he diagnosis of OSA using polysomnography (PSG) is concerned, many practical problems such as an increasing number of patients, expensive testing cost, discomfort during examination, and the limited number of people for testing have been pointed out. Accordingly, for the purpose of substituting PSG researchers have been actively conducting studies on OSA diagnosis based on machine learning using bio signals. In this regard, we review a rich body of existing OSA diagnosis studies applying machine learning techniques based on bio-signal data. As a result, this paper presents a novel taxonomy of the reviewed studies and provides their comprehensive comparative analysis results. Also, we reveal various limitations of the studies using the bio signals and suggest several improvements about utilization of the used machine learning methods. Finally, this paper presents future research topics related to the application of machine learning techniques using bio signals.

수면 장애 중 폐쇄성수면무호흡증은 비교적 흔한 질병 중 하나이다. 환자들은 수면다원검사를 통해 해당 질환의 여부를 알아볼 수 있다. 그러나 수면다원검사를 이용한 폐쇄성수면무호흡증 진단에 관한 한, 늘어나는 환자 수, 비싼 검사 비용, 검사 중 불편함, 수용 인원 제한 등 현실적인 문제점들이 지적됐다. 이에 따라, 수면다원검사를 대체할 목적으로 연구자들은 생체 신호를 활용한 기계학습 기반 폐쇄성수면무호흡증 진단 연구들을 활발히 진행해 왔다. 이 시점에서, 우리는 생체 신호 데이터를 기반으로 기계학습 기법을 적용하는 폐쇄성수면무호흡증 진단 연구를 복기한다. 그 결과, 본 논문은 복기 된 연구들에 대한 최신 분류 체계를 제시하고 그 연구들의 종합적인 비교 분석 결과를 제공한다. 또한, 본 논문은 생체 신호를 활용한 연구들의 다양한 한계점을 밝히고 사용된 기계학습 기법의 활용성에 대한 여러 개선점을 제안한다. 끝으로, 본 논문은 생체 신호를 활용한 기계학습 기법 적용과 관련한 향후 연구 주제를 제시한다.

Keywords

References

  1. Terry Young, Mari Palta, Jerome Dempsey, James Skatrud, Steven Weber, Safwan Badr, "The occurrence of sleep-disordered breathing among middle-aged adults," New England Journal of Medicine 328, no. 17, pp.1230-1235, April 1993, doi: 10.1056/NEJM19930429328170.
  2. Sonia Ancoli-Israel, Einat R, DuHamel, Carl Stepnowsky, Robert Engler, Mairav Cohen-Zion, Matthew Marler, "The relationship between congestive heart failure, sleep apnea, and mortality in older men" Chest 124, no. 4, .pp. 1400-1405, April, 2003. doi:10.1378/chest.124.4.1400.
  3. Sassani, Alex, Larry J, Findley, Meir Kryger, Eric Goldlust, Charles George, and Terence M Davidson, "Reducing Motor-Vehicle Collisions, Costs, and Fatalities by Treating Obstructive Sleep Apnea Syndrome." Sleep 27, no. 3, May 2004, pp.453-458. doi:10.1093/sleep/27.3.453.
  4. Zhao Qing, Liu Zhihong, Zhao Zhohui, Luo Qin, McEvoy, Doug, Zhang, Hongliang and Wang Yong, "Effects of obstructive sleep apnea and its treatment on cardiovascular risk in CAD patients", Heart 97, no. Suppl 3, A136-A136. October, 2011. doi:10.1136/heartjnl-2011-300867.395.
  5. Fatemeh Moharrari, Soheila Saberi, Hadi Asadpour, and Fariba Rezaeetalab, "The correlation of anxiety and depression with obstructive sleep apnea syndrome.", Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 19, no. 3, pp.205, 2014.
  6. Seung Hoon Lee, "Diagnostic Aspects of Polysomnography in Obstructive Sleep Apnea." Journal of the Korean Medical Association 55, no. 2, 138, February, 2012. doi:10.5124/jkma.2012.55.2.138.
  7. Lam, Yuen-yu, Eric Y T, Chan, Daniel K Ng, Chung-hong Chan, Josephine M Y, Cheung, Shuk-yu Leung, Pok-yu Chow, and Ka-li Kwok, "The Correlation Among Obesity, Apnea-Hypopnea Index, and Tonsil Size in Children." Chest 130, no. 6, pp.1751-1756, December, 2006. doi:10.1378/chest.130.6.1751.
  8. Daniel J, Gottlieb, Qing Yao, Susan Redline, Tauqeer Ali, and Mark w Mahowald, "Does Snoring Predict Sleepiness Independently of Apnea and Hypopnea Frequency?" American Journal of Respiratory and Critical Care Medicine 162, no. 4, pp.1512-1517, October, 2000. doi:10.1164/ajrccm.162.4.9911073.
  9. MIT Laboratory for Computational Physiology, "PhysioNet: The Research Resource for Complex Physiologic Signals," URL: https://physionet.org/, accessed on March 28, 2020.
  10. Penzel T, Moody G B, Mark R G, Goldberger A L and Peter J H, "The apnea-ECG database.", In Computers in Cardiology 2000, Vol. 27(Cat. 00CH37163), pp.255-258.
  11. Goldberger A, Amaral L, Glass L, Hausdorff J, Ivanov PC, Mark R, Mietus JE, Moody GB, Peng CK, Stanley HE "PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals." Circulation 101, 23, pp. e215-e220.
  12. Hosmer, David W, Stanley Lemeshow and Rodney X Sturdivant. "Applied Logistic Regression." Wiley Series in Probability and Statistics, March 2013, doi:10.1002/9781118548387.
  13. Subasi A, "EEG Signal Classification Using Wavelet Feature Extraction and a Mixture of Expert Model.", Expert Systems with Applications 32, no. 4, pp.1084-1093, May, 2007. doi:10.1016/j.eswa.2006.02.005.
  14. Suykens J K A and Vandewalle, "Least squares support vector machine classifiers", Neural processing letters, 9(3), pp.293-300, June, 1999. doi: 10.1023/A:1018628609742
  15. Sharma Hemant, and Sharma K K, "An Algorithm for Sleep Apnea Detection from Single-Lead ECG Using Hermite Basis Functions." Computers in Biology and Medicine 77, pp.116-124, October, 2016. doi:10.1016/j.compbiomed.2016.08.012.
  16. Chaw, Hnin Thiri, Sinchai Kamolphiwong, and Krongthong Wongsritrang, "Sleep Apnea Detection Using Deep Learning." Tehnicki Glasnik 13, no. 4. pp.261-266, December, 2019. doi:10.31803/tg-20191104191722.
  17. Lin, Robert, Ren-Guey Lee, Chwan-Lu Tseng, Heng-Kuan Zhou, Chih-feng Chao, and Joe-Air Jiang, "A New Approach for identifiying Sleep Apnea syndrome using Wavelet Transform and Neural Networks." Biomedical Engineering: Applications, Basis and Communications 18, no. 03, June 25, 2006. pp.138-143. doi:10.4015/s1016237206000233.
  18. Taran, Sachin, Varun Bajaj and Dheeraj Sharma, "TEO Separated AM-FM Components for Identification of Apnea EEG Signals." 2017 IEEE 2nd International Conference on Signal and Image Processing (ICSIP) August, 2017. doi:10.1109/siprocess.2017.8124571.
  19. Taran, Sachin and Varun Bajaj, "Sleep Apnea Detection Using Artificial Bee Colony Optimize Hermite Basis Functions for EEG Signals." IEEE Transactions on Instrumentation and Measurement 69, no.2, February 2020. pp.608-616. doi:10.1109/tim.2019.2902809.
  20. Khandoker, Ahsan H, Chandan K, Karmakar, and Marimuthu Palaniswami, "Automated Recognition of Patients with Obstructive Sleep Apnoea Using Wavelet-Based Features of Electrocardiogram Recordings." Computers in Biology and Medicine 39, no. 1, January, 2009. pp.88-96. doi:10.1016/j.compbiomed.2008.11.003.
  21. Quiceno-Manrique A F, Alonso-Hernandez J B, Travieso-Gon zalez C M, Ferrer-Ballester M A, and Castellanos-Dominguez G, "Detection of Obstructive Sleep Apnea in ECG Recordings Using Time-Frequency Distributionsand Dynamic Features." 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, September, 2009. doi:10.1109/iembs.2009.5333736.
  22. Alvarez, Hornero D R, Marcos J V, Campo F del and Lopez M, "Spectral Analysis of Electroencephalogram and Oximetric Signals in Obstructive Sleep Apnea Diagnosis." 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, September, 2009. doi:10.1109/iembs.2009.5334905.
  23. Almazaydeh, Elleithy L K, and Faezipour M, "Obstructive Sleep Apnea Detection Using SVM-Based Classification of ECG Signal Features." 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, August, 2012. doi:10.1109/embc.2012.6347100.
  24. Nguyen, Hoa Dinh, Brek A, Wilkins, Qi Cheng, and Bruce Allen Benjamin, "An Online Sleep Apnea Detection Method Based on Recurrence Quantification Analysis." IEEE Journal of Biomedical and Health Informatics 18, no. 4, pp.1285-1293, July, 2014. doi:10.1109/jbhi.2013.2292928.
  25. Jafari and Ayyoob, "Sleep Apnoea Detection from ECG Using Features Extracted from Reconstructed Phase Space and Frequency Domain." Biomedical Signal Processing and Control 8, no. 6, pp.551-558, November, 2013. doi:10.1016/j.bspc.2013.05.007.
  26. Da Silva Pinho, Andre Miguel, Nuno Pombo and Nuno M Garcia, "Sleep Apnea Detection Using a Feed-Forward Neural Network on ECG Signal." 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom), September, 2016. doi:10.1109/healthcom.2016.7749468.
  27. Sharma, Hemant, and K K Sharma, "An Algorithm for Sleep Apnea Detection from Single-Lead ECG Using Hermite Basis Functions." Computers in Biology and Medicine 77, pp.116-124, October, 2016. doi:10.1016/j.compbiomed.2016.08.012.
  28. Abraham Otero, Santiago F Dapena, Paulo Felix, Jesus Presedo, Miguel Tarasco, "A low cost screening test for obstructive sleep apnea that can be performed at the patient's home" In 2009 IEEE International Symposium on Intelligent Signal Processing, pp. 199-204, November, 2009.
  29. Laguna, Pablo, Raimon Jané, and Pere Caminal, "Automatic Detection of Wave Boundaries in Multilead ECG Signals: Validation with the CSE Database." Computers and Biomedical Research 27, no. 1, pp.45-60, February, 1994. doi:10.1006/cbmr.1994.1006.
  30. Pan, Jiapu, and Willis J Tompkins, "A Real-Time QRS Detection Algorithm." IEEE Transactions on Biomedical Engineering BME-32, no. 3, pp.230-236, March, 1985. doi:10.1109/tbme.1985.325532.
  31. Rachim, Vega Pradana, Gang Li, and Wan-Young Chung, "Sleep Apnea Classification Using ECG-Signal Wavelet-PCA Features." Bio-Medical Materials and Engineering 24, no. 6 , pp.2875-2882, September 2014. doi:10.3233/bme-141106.
  32. Hassan, Ahnaf Rashik, and Md, Aynal Haque, "Computer-Aided Obstructive Sleep Apnea Screening from Single-Lead Electrocardiogram Using Statistical and Spectral Features and Bootstrap Aggregating." Biocybernetics and Biomedical Engineering 36, no. 1, pp.256-266, November, 2015. doi:10.1016/j.bbe.2015.11.003.
  33. Hassan and Ahnaf Rashik, "Computer-Aided Obstructive Sleep Apnea Detection Using Normal Inverse Gaussian Parameters and Adaptive Boosting." Biomedical Signal Processing and Control 29, pp.22-30, August, 2016. doi:10.1016/j.bspc.2016.05.009.
  34. Hassan, Ahnaf Rashik, Syed Khairul Bashar, and Mohammed Imamul Hassan Bhuiyan, "Computerized Obstructive Sleep Apnea Diagnosis from Single-Lead ECG Signals Using Dual-Tree Complex Wavelet Transform." 2017 IEEE Region 10 Humanitarian Technology Conference (R10-HTC), December, 2017. doi:10.1109/r10-htc.2017.8288902.
  35. Hassan, Ahnaf Rashik, and Md Aynal Haque, "An Expert System for Automated Identification of Obstructive Sleep Apnea from Single-Lead ECG Using Random Under Sampling Boosting." Neurocomputing 235, pp.122-130, April, 2017. doi:10.1016/j.neucom.2016.12.062.
  36. Sharma, Manish, Mitesh Raval, and U Rajendra Acharya, "A New Approach to Identify Obstructive Sleep Apnea Using an Optimal Orthogonal Wavelet Filter Bank with ECG Signals." Informatics in Medicine Unlocked 16, 100170, March, 2019. doi:10.1016/j.imu.2019.100170.
  37. Urtnasan, Erdenebayar, Jong-Uk Park, and Kyoung-Joung Lee, "Multiclass Classification of Obstructive Sleep Apnea/hypopnea Based on a Convolutional Neural Network from a Single-Lead Electrocardiogram." Physiological Measurement 39, no. 6, 065003, June, 2018. doi:10.1088/1361-6579/aac7b7.
  38. Kunyang Li, Weifeng Pan, Yifan Li, Qing Jiang, and Guanzheng Liu, "A Method to Detect Sleep Apnea Based on Deep Neural Network and Hidden Markov Model Using Single-Lead ECG Signal." Neurocomputing 294, pp. 94-101, June, 2018. doi:10.1016/j.neucom.2018.03.011.
  39. Erdenebayar, Urtnasan, Yoon Ji Kim, Jong-Uk Park, Eun Yeon Joo, and Kyoung-Joung Lee, "Deep Learning Approaches for Automatic Detection of Sleep Apnea Events from an Electrocardiogram." Computer Methods and Programs in Biomedicine 180, 105001, October, 2019. doi:10.1016/j.cmpb.2019.105001.
  40. Al-Angari H M, and A V Sahakian, "Automated Recognition of Obstructive Sleep Apnea Syndrome Using Support Vector Machine Classifier." IEEE Transactions on Information Technology in Biomedicine 16, no. 3, pp.463-468, May 2012. doi:10.1109/titb.2012.2185809.
  41. Xie B and Hlaing Minn, "Real-Time Sleep Apnea Detection by Classifier Combination." IEEE Transactions on Information Technology in Biomedicine 16, no. 3, pp.469-477, May, 2012. doi:10.1109/titb.2012.2188299.
  42. Abedi, Zahra, Nadia Naghavi and Fariborz Rezaeitalab, "Detection and Classification of Sleep Apnea Using Genetic Algorithms and SVM-Based Classification of Thoracic Respiratory Effort and Oximetric Signal Features." Computational Intelligence 33, no. 4, pp.1005-1018, August, 2017. doi:10.1111/coin.12138.
  43. Mostafa, Sheikh Shanawaz, Joao Paulo Carvalho, Fernando Morgado-Dias and Antonio Ravelo-Garcia, "Optimization of Sleep Apnea Detection Using SpO2 and ANN." 2017 XXVI International Conference on Information, Communication and Automation Technologies (ICAT), October, 2017. doi:10.1109/icat.2017.8171609.
  44. Bijoy Laxmi Koley and Debangshu Dey, "Selection of Features for Detection of Obstructive Sleep Apnea Events." 2012 Annual IEEE India Conference (INDICON). December, 2012. doi:10.1109/indcon.2012.6420761.
  45. Avci, Cafer and Ahmet Akbas, "Sleep Apnea Classification Based on Respiration Signals by Using Ensemble Methods." , Bio-Medical Materials and Engineering 26, no. s1, pp. S1703-S1710, August, 2015. doi:10.3233/bme-151470.
  46. Almazaydeh L, K Elleithy, and M Faezipour, "Obstructive Sleep Apnea Detection Using SVM-Based Classification of ECG Signal Features." 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, August, 2012. doi:10.1109/embc.2012.6347100.
  47. Nishad, Anurag, Ram Bilas Pachori and U Rajendra Acharya, "Application of TQWT Based Filter-Bank for Sleep Apnea Screening Using ECG Signals", Journal of Ambient Intelligence and Humanized Computing, pp.1-12, May, 2018. doi:10.1007/s12652-018-0867-3.
  48. Viswabhargav, ChS.S.S., R.K. Tripathy, and U. Rajendra Acharya, "Automated Detection of Sleep Apnea Using Sparse Residual Entropy Features with Various Dictionaries Extracted from Heart Rate and EDR Signals." Computers in Biology and Medicine 108, pp.20-30, May, 2019. doi:10.1016/j.compbiomed.2019.03.016.
  49. Prabha, Anju, Akta Trivedi, A. Anand Kumar, and C Santhosh Kumar, "Automated System for Obstructive Sleep Apnea Detection Using Heart Rate Variability and Respiratory Rate Variability." 2017 International Conference on Advances in Computing, Communications and Informatics (ICACCI), September, 2017. doi:10.1109/icacci.2017.8126021.
  50. Erdenebayar, Urtnasan, Yoon Ji Kim, Jong-Uk Park, Eun Yeon Joo and Kyoung-Joung Lee, "Deep Learning Approaches for Automatic Detection of Sleep Apnea Events from an Electrocardiogram." Computer Methods and Programs in Biomedicine 180, 105001, October, 2019. doi:10.1016/j.cmpb.2019.105001.
  51. Vimala, V., K. Ramar, and M Ettappan, "An Intelligent Sleep Apnea Classification System Based on EEG Signals." Journal of Medical Systems 43, 36, January, 2019. doi:10.1007/s10916-018-1146-8.
  52. Nakano, Hiroshi, Tomokazu Furukawa, and Takeshi Tanigawa, "Tracheal Sound Analysis Using a Deep Neural Network to Detect Sleep Apnea." Journal of Clinical Sleep Medicine 15, no. 08, pp.1125-1133, August, 2019. doi:10.5664/jcsm.7804.