Journal of Korean Biological Nursing Science

Korean society of Biological Nursing Science (한국기초간호학회)
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Effects of Long- and Short-term Consumption of Energy Drinks on Anxiety-like, Depression-like, and Cognitive Behavior in Adolescent Rats

  • Received : 2020.03.21
  • Accepted : 2020.05.18
  • Published : 2020.05.31
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Abstract

Purpose: The purpose of this study was to understand the impact of long- and short-term energy drinks on anxiety-like, depressionlike, and cognitive behavior in adolescent rats. Methods: Adolescent rats (age six weeks) were randomly classified into a control group (CON), a long-term administration group (LT), and a short-term administration group (ST). The LT group was orally administered 1.5 mL/100 g (body weight) of energy drink twice daily for 14 days, the ST group was orally administered for one day, and the control group applied the same amount of normal saline. Later, an open-field test, a forced swim test, novel object recognition test, and an 8-arm radial maze test was conducted to assess the rats' anxiety, depression, and cognitive function. Results: There were different effects in the long- and short-term groups of energy drink administration. In the LT group, anxiety- and depressive-like behavior increased because of increased movement in the side corner and decrease of immobility time. Also, the time to explore novel objects decreased, and the number of correct responses was reduced, indicating a learning and memory function disorder. However, the ST group was not different from the control group. Conclusion: These results indicate that long-term consumption of energy drinks can increase anxiety-like, depression-like behavior, and this can lead to decrease in learning and memory functions. Thus, nurse and health care providers should understand the impact of energy drink consumption in adolescence to provide appropriate practices and education.

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References

  1. Lim HO. Survey on safety of energy drink. Trend report. Seoul: Korea Consumer Agency; 2013.
  2. Ministry of gender equality and family. Frequency of use of high caffeine (energy) drinks [Internet]. Seoul: Statistic Korea: 2018. [cited 2019 Nov 04] Available from: http://kosis.kr/statHtml/statHtml.do?orgId=154&tblId=DT_MOGE_1540002721&conn_path=I2
  3. Higgins JP, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clinic Proceedings. 2010;85(11):1033-1041. https://doi.org/10.4065/mcp.2010.0381
  4. Wassef B, Kohansieh M, Makaryus AN. Effects of energy drinks on the cardiovascular system. Journal of World Cardiology. 2017;9(11):796-806. https://doi.org/10.4330%2Fwjc.v9.i11.796 https://doi.org/10.4330/wjc.v9.i11.796
  5. Lunt MJ, Ragab S, Birch AA, Schley D, Jenkinson DF. Comparison of caffeine-induced changes in cerebral blood flow and middle cerebral artery blood velocity shows that caffeine reduces middle cerebral artery diameter. Physiological Measurement. 2004;25(2):467-474. https://doi.org/10.1088/0967-3334/25/2/006
  6. Mangi MA, Rehman H, Rafique M, Illovsky M. Energy drinks and the risk of cardiovascular disease: a review of current literature. Cureus. 2017;9(6):e1322. https://doi.org/10.7759%2Fcureus.1322
  7. Richards G, Smith AP. A review of energy drinks and mental health, with a focus on stress, anxiety, and depression. Journal of Caffeine Research. 2016;6(2):49-63. https://doi.org/10.1089%2Fjcr.2015.0033 https://doi.org/10.1089/jcr.2015.0033
  8. Buchanan JK. Energy drink consumption (with and without alcohol) and its relationship to risky behavior, risk awareness, and behavioral intention in college students [Dissertation]. Kentucky: University of Kentucky; 2012. p. 37-55
  9. Giedd JN. The teen brain: insights from neuroimaging. Journal of Adolescent Health. 2008;42(4): 335-343. https://doi.org/10.1016/j.jadohealth.2008.01.007
  10. Gathercole SE, Pickering SJ, Ambridge B, Wearing H. The structure of working memory from 4 to 15 years of age. Developmental Psychology. 2004;40(2):177-190. https://doi.org/10.1037/0012-1649.40.2.177
  11. Reissig CJ, Strain EC, Griffiths RR. Caffeinated energy drinks-a growing problem. Drug and Alcohol Dependence. 2009;99(1):1-10. https://doi.org/10.1016/j.drugalcdep.2008.08.001
  12. Lee SJ, Kim HC, Kim MR. Analysis on intake of energy drinks of high school students in Gyeoungbuk region. The East Asian Society of Dietary Life. 2014;24(6):924-932. https://doi.org/10.17495/easdl.2014.12.24.6.924
  13. Park JH, Hahm MI, Kim SJ, Min IS. Association between high-caffeine energy drink intake and suicidal ideation in Korean adolescents. Journal of the Korean Society of School Health. 2016;29(2): 71-80. https://doi.org/10.15434/kssh.2016.29.2.71
  14. Skewes MC, Decou CR, Gonzalez VM. Energy drink use, problem drinking and drinking motives in a diverse sample of Alaskan college students. International Journal of Circumpolar Health. 2013;72(1):1-6. https://doi.org/10.3402/ijch.v72i0.21204
  15. Mattson ME. Update on emergency department visits involving energy drinks: a continuing public health concern [Internet]. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2013[cited 2020 Apr 24]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK384664/ PMID: 27606410
  16. Charan J, Kantharia ND. How to calculate sample size in animal studies? Journal of Pharmacy & Pharmacotherapeutics. 2013;4(4): 303-306. https://doi.org/10.4103/0976-500X.1197266
  17. Seibenhener ML, Wooten MC. Use of the open field maze to measure locomotor and anxiety-like behavior in mice. Journal of Visualized Experiments. 2015;(96):e52434. https://doi org/10.3791/52434
  18. Slattery DA, Cryan JF. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nature Protocols. 2012;7(6): 1009-1014. https://doi.org/10.1038/nprot.2012.044
  19. McConnell EL, Basit AW, Murdan S. Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in vivo experiments. The Journal of Pharmacy and Pharmacology. 2008;60(1):63-70. https://doi.org/10.1211/jpp.60.1.0008
  20. Yoo HS, Sim KH. Survey on the high-caffeine energy drink consumption status of university students in Seoul. The East Asian Society of Dietary Life. 2014;24(3):407-420. https://doi.org/10.17495 /easdl.2014.06.24.3.407
  21. Nehlig A. Are we dependent upon coffee and caffeine? A review on human and animal data. Neuroscience & Biobehavioral Reviews. 1999;23(4):563-576. https://doi.org/10.1016/S0149-7634%2898%2900050-5
  22. Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review. The American Journal of Clinical Nutrition. 2006;84(2):274-288. https://doi.org/10.1093/ajcn/84.1.274
  23. Park JM, Kim Y, Kim H, Kim YJ. Influence of short-and long-term high-dose caffeine administration on behavior in an animal model of adolescence. Journal of Korean Biological Nursing Science. 2019;21(3):217-223. https://doi.org/10.7586/jkbns.2019.21.3.217
  24. Keijzers GB, De Galan BE, Tack CJ, Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002;25(2): 364-369. https://doi.org/10.2337/diacare.25.2.364
  25. Rush E, Schulz S, Obolonkin V, Simmons D, Plank L. Are energy drinks contributing to the obesity epidemic? Asia Pacific Journal of Clinical Nutrition. 2006;15(2): 242-244.
  26. Lara B, Gonzalez-Millan C, Salinero JJ, Abian-Vicen J, Areces F, Barbero-Alvare JC, et al. Caffeine-containing energy drink improves physical performance in female soccer players. Amino Acids. 2014;46(5):1385-1392. https://doi.org/10.1007/s00726-014-1709-z
  27. Wesnes KA, Barrett ML, Udani JK. An evaluation of the cognitive and mood effects of an energy shot over a 6 h period in volunteers. A randomized, double-blind, placebo controlled, cross-over study. Appetite. 2013;67:105-113. https://doi.org/10.1016/j.appet.2013.04.005
  28. Salinero JJ, Lara B, Abian-Vicen J, Gonzalez-Millan C, Areces F, Gallo-Salazar C, et al. The use of energy drinks in sport: perceived ergogenicity and side effects in male and female athletes. British Journal of Nutrition. 2014; 112(9):1494-1502. https://doi.org/10.1017/S0007114514002189
  29. Champlin SE, Pasch KE, Perry CL. Is the consumption of energy drinks associated with academic achievement among college students? Journal of Primary Prevention. 2016;37(4):345-359. https://doi.org/10.1007/s10935-016-0437-4
  30. Bawazir AE. Effects of Energy Drink (Red bull) on some neurotransmitters content and histological structure in the hippocampus region in male albino rats. International Journal of Pharmaceutical Research & Allied Sciences. 2017;6(2):263-276.
  31. Beilharz JE, Maniam J, Morris MJ. Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation. Behavioural Brain Research. 2016;306: 1-7. https://doi.org/10.1016/j.bbr.2016.03.018
  32. Jacques A, Chaaya N, Beecher K, Ali SA, Belmer A, Bartlett S. The impact of sugar consumption on stress driven, emotional and addictive behaviors. Neuroscience & Biobehavioral Reviews. 2019;103:178-199. https://doi.org/10.1016/j.neubiorev.2019.05.021