대한본초학회지 (The Korea Journal of Herbology)

  • 제35권5호
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  • Pages.1-12
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  • 2020
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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죽엽황금복합추출물 BS21의 고지방식이 유도 비만 동물모델에서의 지방생성 및 고요산혈증 개선 효과

BS21, a combination of Phyllostachys pubescens and Scutellaria baicalensis extracts, reduces adiposity and hyperuricemia in high-fat diet-induced obese mice

  • 성윤영 (한국한의학연구원 한약연구부) ;
  • 이영실 (한국한의학연구원 한약연구부) ;
  • 김승형 (대전대학교 동서생명과학연구원) ;
  • 김동선 (한국한의학연구원 한약연구부)
  • Sung, Yoon-Young (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Young-Sil (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University) ;
  • Kim, Dong-Seon (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 투고 : 2020.08.05
  • 심사 : 2020.09.25
  • 발행 : 2020.09.30
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초록

Objectives : Phyllostachys pubescens and Scutellaria baicalensis are considered to be effective in promoting blood circulation in traditional medicine. In this study, we examined whether a mixture of P. pubescens leaves and S. baicalensis root (BS21) had any anti-obesity, anti-hyperlipidemia, or anti-hyperuricemia effects and the possible mechanisms of action. Methods : We examined the effects of BS21 in high-fat diet (HFD)-induced obese mice. Mice were fed HFD with BS21 (75, 150, or 300 mg/kg) or Garcinia cambogia extracts (245 mg/kg) as a positive control for 8 weeks. At the end of 8 weeks, body weight, liver and adipose weight, adipocyte size, plasma lipid profiles, adipokine and uric acid levels, and adipose tissue expression levels in obesity and uric acid production-related genes were examined. Results : BS21 decreased body weight gain, white adipose tissue, liver weight, adipocyte size, and liver triglyceride accumulation. It also reduced levels of plasma glucose, triglycerides, non-esterified fatty acids, total cholesterol, low-density lipoprotein cholesterol, alanine transaminase, leptin, and uric acid. In contrast, BS21 increased adiponectin levels. Furthermore, BS21 decreased the expression levels of adipogenesis-related genes, such as peroxisome proliferator-activated receptor γ, sterol regulatory element binding protein-1c, and fatty acid synthase, as well as xanthine oxidoreductase, which is involved in uric acid production. Conclusions : These results suggest that BS21 may exert anti-obesity, anti-hyperlipidemia, and anti-hyperuricemia effects in HFD-induced obese mice by regulating the expression of xanthine oxidoreductase and adipogenesis-related genes.

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