대한본초학회지 (The Korea Journal of Herbology)

  • 제35권5호
  • /
  • Pages.13-21
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  • 2020
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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감초 신품종 및 약전 수재감초의 항알러지 효과 비교 연구

The Comparative Study of Anti-allergic Effect by Glycyrrhiza New Varieties and Official Compendia

  • 강윤미 (상지대학교 한의과대학 약리학교실) ;
  • 김원남 (세명대학교 한의과대학 본초방제학교실) ;
  • 진종식 (전북대학교 환경생명자원대학 한약자원학과) ;
  • 이종현 (동덕여자대학교 약학대학 약학과) ;
  • 장재기 (농촌진흥청 국립원예특작과학원 약용작물과) ;
  • 이정훈 (농촌진흥청 국립원예특작과학원 약용작물과) ;
  • 안효진 (상지대학교 한의과대학 약리학교실)
  • Kang, Yun-Mi (Department of Pharmacology, College of Korean Medicine, Sangji University) ;
  • Kim, Wonnam (Division of Pharmacology, College of Korean Medicine, Semyung University) ;
  • Jin, Jong-Sik (Department of Oriental Medicine Resources, Jeonbuk National University) ;
  • Lee, Jong-Hyun (Department of Pharmacy, College of Pharmacy, Dongduk Women's University) ;
  • Chang, Jae Ki (Herbal Crop Research Division, NIHHS, RDA) ;
  • Lee, Jeonghoon (Herbal Crop Research Division, NIHHS, RDA) ;
  • An, Hyo-Jin (Department of Pharmacology, College of Korean Medicine, Sangji University)
  • 투고 : 2020.08.06
  • 심사 : 2020.09.25
  • 발행 : 2020.09.30
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초록

Objective : The genus Glycyrrhiza has been used in food and traditional herbal medicine. Many experimental studies reported that Glycyrrhiza species possess several pharmacological properties. Glycyrrhiza new varieties WONGAM and SINWONGAM have been developed by Korea Rural Development Administration doing research for registration on Ministry of Food and Drug Safety. During the evaluations about pharmacological effect of Glycyrrhiza new varieties WONGAM and SINWONGAM, we focused the anti-allergic effect in this study. Methods : We investigated the anti-allergic effect of WONGAM and SINWONGAM compared with Glycyrrhiza uralensis Fischer and G. glabra L. using anti-dinitrophenyl-immunoglobulin E (IgE)/human serum albumin-stimulated RBL-2H3 cells, phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 cells and compound 48/80-induced anaphylaxis mice model. We analyzed the effect on the expression of various cytokines, and IgE from mast cells and the underlying molecular mechanisms of WONGAM and SINWONGAM in presented models. Results : WONGAM and SINWONGAM showed the inhibitory effect on the histamine release from rat peritoneal mast cells or human mast cells without cytotoxicity. WONGAM and SINWONGAM blocked anaphylactic shock and decreased the IgE production. Furthermore, WONGAM and SINWONGAM inhibited the productions of TNF-α and IL-6 in compound 48/80-induced anaphylaxis mice model. Conclusion : These results indicated that WONGAM and SINWONGAM would have protect effect on allergic responses through the inhibition of allergic mediators and pro-inflammatory cytokines. This study may facilitate the development on Glycyrrhiza new varieties for allergy.

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참고문헌

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