동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제31권3호
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  • Pages.149-156
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  • 2020
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
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ADHD 동물모델에서 가감청심연자탕의 효과에 관한 실험연구

An Experimental Study on the Effect of Chengsimyeonjatang-gagam Extracts on the ADHD Animal Model

  • 오영제 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 류천봉 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 김만기 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 홍민호 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 김근우 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 구병수 (동국대학교 한의과대학 한방신경정신과학교실)
  • Oh, Young-je (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Liu, Quan Feng (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim, Man-gi (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Hong, Min-ho (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim, Geun-woo (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Koo, Byung-soo (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University)
  • 투고 : 2020.08.31
  • 심사 : 2020.09.22
  • 발행 : 2020.09.30
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초록

Objectives: The purpose of this study was to experimentally assess the effects of Chengsimyeonjatanggagam extracts in the animal model regarding ADHD related symptoms and indicators. Methods: The experimental group was classified into the normal group (WKY rat) in 7, the control group (SHR rat) in 7, the low-concentration group of herbal medicines (SHR rat) in 7, and the high-concentration group of herbal medicines (SHR rat) in 7 by random sampling. The open field test was conducted three times on the 7th, 14th, and 21st days during the oral medication. After that, Y-maze test, intestinal permeability verification (L/M ratio), and Western blotting (CDK expression in the cerebral cortex) were performed in sequence. Results: The Chengsimyeonjatang-gagam extracts reduced the activity distance in the SHR rat at 21 days in the low and high concentration groups by the open field test. It also reduced the cross-action rate in the low and high concentration groups by the Y-maze test. And the low concentration group showed 52.3% decrease in the L/M ratio compared to the SHR group. Finally, the CDK5 protein significantly increased in the low and high concentration groups. Conclusions: This study suggests that the Chengsimyeonjatang-gagam extracts have potential to be used for the treatment of ADHD.

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