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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Extracellular matrixes and neuroinflammation

  • Jang, Dong Gil (School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)) ;
  • Sim, Hyo Jung (School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)) ;
  • Song, Eun Kyung (School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)) ;
  • Kwon, Taejoon (School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)) ;
  • Park, Tae Joo (School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST))
  • Received : 2020.07.23
  • Published : 2020.10.31
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Abstract

The extracellular matrix is a critical component of every human tissue. ECM not only functions as a structural component but also regulates a variety of cellular processes such as cell migration, differentiation, proliferation, and cell death. In addition, current studies suggest that ECM is critical for the pathophysiology of various human diseases. ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid. Each component of ECM exerts its own functions in cellular and pathophysiological processes. One of the interesting recent findings is that ECM is involved in inflammatory responses in various human tissues. In this review, we summarized the known functions of ECM in neuroinflammation after acute injury and chronic inflammatory diseases of the central nerve systems.

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References

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