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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Human collagen alpha-2 type I stimulates collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs)

  • Hwang, Su Jin (ABIOTECH Co., Ltd.) ;
  • Ha, Geun-Hyoung (ABIOTECH Co., Ltd.) ;
  • Seo, Woo-Young (ABIOTECH Co., Ltd.) ;
  • Kim, Chung Kwon (Department of Anatomy and Cell Biology, Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University School of Medicine) ;
  • Kim, KyeongJin (Department of Biomedical Sciences, College of Medicine, Inha University) ;
  • Lee, Sang Bae (Division of Life Sciences, Jeonbuk National University)
  • Received : 2020.06.05
  • Accepted : 2020.07.20
  • Published : 2020.10.31
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Abstract

Skin aging appears to be the result of overlapping intrinsic (including genetic and hormonal factors) and extrinsic (external environment including chronic light exposure, chemicals, and toxins) processes. These factors cause decreases in the synthesis of collagen type I and elastin in fibroblasts and increases in the melanin in melanocytes. Collagen Type I is the most abundant type of collagen and is a major structural protein in human body tissues. In previous studies, many products containing collagen derived from land and marine animals as well as other sources have been used for a wide range of purposes in cosmetics and food. However, to our knowledge, the effects of human collagen-derived peptides on improvements in skin condition have not been investigated. Here we isolate and identify the domain of a human COL1A2-derived protein which promotes fibroblast cell proliferation and collagen type I synthesis. This human COL 1A2-derived peptide enhances wound healing and elastin production. Finally, the human collagen alpha-2 type I-derived peptide (SMM) ameliorates collagen type I synthesis, cell proliferation, cell migration, and elastin synthesis, supporting a significant anti-wrinkle effect. Collectively, these results demonstrate that human collagen alpha-2 type I-derived peptides is practically accessible in both cosmetics and food, with the goal of improving skin condition.

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References

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