Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Evaluating the effects of probiotics in pediatrics with recurrent abdominal pain

  • Rahmani, Parisa (Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences) ;
  • Ghouran-Orimi, Azin (Iran university of Medical Sciences) ;
  • Motamed, Farzaneh (Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences) ;
  • Moradzadeh, Alireza (Department of Pediatric Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences)
  • 투고 : 2019.12.17
  • 심사 : 2020.05.20
  • 발행 : 2020.12.15
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초록

Background: Recurrent abdominal pain (RAP) is one of the frequent complaints in general practice, particularly in pediatrics and is among the common cause of referral to gastroenterology clinics. Purpose: This study is designed to investigate the effects of probiotics for the treatment of RAP and desired therapeutic outcomes. Methods: One hundred twenty-five children with the diagnosis of RAP according to Rome III criteria for irritable bowel syndrome (IBS), functional abdominal pain (FAP), functional dyspepsia (FD), and abdominal migraine (AM), were enrolled in this double-blind randomized controlled trial. Results: Sixty-five subjects received probiotics, and others received placebo treatment for 4 weeks. Lactobacillus reuteri was therapeutically effective in 32 patients compared to 8 patients, responding to the placebo treatment. Compared to baseline, all pain-related variables showed a significant reduction for the IBS and FD at the end of the 4th week. However, it did not respond well in FAP and AM groups. Pain-related outcomes such as, frequency of the pain, severity, and duration of the pain were decreased following the probiotic treatment. No therapeutic response was seen in AM group after the administration of probiotics. L. reuteri significantly led to pain relief in the overall population, and also in FAP, FD, and IBS subgroups. Conclusion: L. reuteri probiotics are likely to lead to RAP relief and can be recommended for the treatment of functional gastrointestinal disorders.

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과제정보

We greatly thank "Tehran University of Medical Sciences, Tehran, Iran" for their cooperation and support.

참고문헌

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피인용 문헌

  1. An Update on the Assessment and Management of Pediatric Abdominal Pain vol.12, 2020, https://doi.org/10.2147/phmt.s287719
  2. Efficacy of probiotic adjuvant therapy for irritable bowel syndrome in children: A systematic review and meta-analysis vol.16, pp.8, 2020, https://doi.org/10.1371/journal.pone.0255160
  3. A cross‐sectional study on evaluation of complete blood count‐associated parameters for the diagnosis of acute appendicitis vol.4, pp.3, 2020, https://doi.org/10.1002/hsr2.326