Journal of Korean Foot and Ankle Society (대한족부족관절학회지)

Korean Foot & Ankle Society (대한족부족관절학회)
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Relationship between the Diurnal Temperature Range and Wound Healing of Diabetic Foot: Animal Study

일교차가 당뇨병성 창상의 치유에 미치는 영향: 동물 실험 연구

  • Won, Sung Hun (Department of Orthopedic Surgery, Soon Chun Hyang University Seoul Hospital) ;
  • Chun, Dong-Il (Department of Orthopedic Surgery, Soon Chun Hyang University Seoul Hospital) ;
  • Cho, Jaeho (Department of Orthopaedic Surgery, Hallym University Chuncheon Sacred Heart Hospital) ;
  • Park, In Keun (Department of Orthopedic Surgery, Inje University Seoul Paik Hospital) ;
  • Yi, Young (Department of Orthopedic Surgery, Inje University Seoul Paik Hospital)
  • 원성훈 (순천향대학교 서울병원 정형외과) ;
  • 천동일 (순천향대학교 서울병원 정형외과) ;
  • 조재호 (한림대학교 춘천성심병원 정형외과) ;
  • 박인근 (인제대학교 서울백병원 정형외과) ;
  • 이영 (인제대학교 서울백병원 정형외과)
  • Received : 2020.10.29
  • Accepted : 2020.12.02
  • Published : 2020.12.15
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Abstract

Purpose: Diabetic foot ulcers are closely related to body surface heat, which can be affected easily by temperature differences. This study examined the correlation between the healing process of diabetic wounds and abnormal diurnal temperature through an animal study. Materials and Methods: Rats in the abnormal diurnal temperature group and control group were given a 10 mm sized full-thickness skin ulcer. Wound size progression was observed in both groups. H&E and Masson's trichrome staining was performed at 14 days after wound formation, and the number of vessels per unit area and histology analysis were performed. The changes in the ulcer were measured through three dimensional cross-section area using INSIGHT® devices. Results: The wound recovery period (granulation ingrowing) was 24 days in the abnormal diurnal temperature model and 20 days in the control group. The thickness of scar tissue was 402±23.19 ㎛ in the control group and 424.5±36.94 ㎛ in the diurnal temperature model. Neovascular formation was counted as 5.1±0.97 for the control group and 4.16±0.94 for the diurnal temperature model group. Conclusion: Delayed and inferior diabetic wound healing was observed in the abnormal diurnal temperature group, which was characterized by greater diurnal variations than the typical growth environment.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2018R1C15042849).

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