Effect of Skin Tissue Necrosis Relaxation by Low Frequency Pulsed Electromagnetic Fields (LF-PEMF) Stimulation

저주파 펄스 전자기장 자극에 의한 피부 조직괴사 완화 효과

  • Lee, Jawoo (Biomedical Electromagnetic System Laboratory, Department of Biomedical Engineering, Yonsei University) ;
  • Kim, Junyoung (Biomedical Electromagnetic System Laboratory, Department of Biomedical Engineering, Yonsei University) ;
  • Lee, Yongheum (Biomedical Electromagnetic System Laboratory, Department of Biomedical Engineering, Yonsei University)
  • 이자우 (연세대학교 보건과학대학 의공학부, 의료전자기시스템 연구실) ;
  • 김준영 (연세대학교 보건과학대학 의공학부, 의료전자기시스템 연구실) ;
  • 이용흠 (연세대학교 보건과학대학 의공학부, 의료전자기시스템 연구실)
  • Received : 2021.02.01
  • Accepted : 2021.02.22
  • Published : 2021.02.28


Objective: The aim of this study is to consider the effect of skin tissue necrosis by improving blood flow in animal skin models for low frequency pulsed electromagnetic fields (LF_PEMF) stimulation. Methods: Twenty rats (Wistar EPM-1 male, 280-320 g) were randomly divided into control groups (n=10) and the PEMF groups (n=10). To induce necrosis of the skin tissue, skin flap was treated in the back of the rat, followed by isolation film and skin flap suturing. Subsequently, the degree of necrosis of the skin tissue was observed for 7 days. The control group did not perform any stimulation after the procedure. For the PEMF group, LF_PEMF (1 Hz, 10 mT) was stimulated in the skin flap area, for 30 minutes a day and 7 days. Cross-polarization images were acquired at the site and skin tissue necrosis patterns were analyzed. Results: In the control group, skin tissue necrosis progressed rapidly over time. In the PEMF group, skin tissue necrosis was slower than the control group. In particular, no further skin tissue necrosis progress on the day 6. Over time, a statistically significant difference from the continuous necrosis progression pattern in the control group was identified (p<0.05). Conclusions: It was confirmed that low frequency pulsed electromagnetic fields (LF_PEMF) stimulation can induce relaxation of skin tissue necrosis.


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