Journal of Ginseng Research

  • 제45권6호
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  • Pages.717-725
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  • 2021
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice

  • Kim, Jin Kyeong (Department of Integrative Biotechnology, Sungkyunkwan University) ;
  • Shin, Kon Kuk (Department of Integrative Biotechnology, Sungkyunkwan University) ;
  • Kim, Haeyeop (Department of Integrative Biotechnology, Sungkyunkwan University) ;
  • Hong, Yo Han (Department of Integrative Biotechnology, Sungkyunkwan University) ;
  • Choi, Wooram (Department of Integrative Biotechnology, Sungkyunkwan University) ;
  • Kwak, Yi-Seong (R&D Headquarters, Korea Ginseng Corporation) ;
  • Han, Chang-Kyun (R&D Headquarters, Korea Ginseng Corporation) ;
  • Hyun, Sun Hee (R&D Headquarters, Korea Ginseng Corporation) ;
  • Cho, Jae Youl (Department of Integrative Biotechnology, Sungkyunkwan University)
  • 투고 : 2021.02.10
  • 심사 : 2021.03.30
  • 발행 : 2021.11.15
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초록

Background: Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, the underlying mechanisms of anti-inflammatory and autophagy-promoting effects were investigated in aged mice treated with KRG-water extract (WE) over a long period. Methods: The mechanisms of anti-inflammatory and autophagy-promoting activities of KRG-WE were evaluated in kidney, lung, liver, stomach, and colon of aged mice using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (qRT-PCR), and western blot analysis. Results: KRG-WE significantly suppressed the mRNA expression levels of inflammation-related genes such as interleukin (IL)-1β, IL-8, tumor necrosis factor (TNF)- α, monocyte chemoattractant protein-1 (MCP-1), and IL-6 in kidney, lung, liver, stomach, and colon of the aged mice. Furthermore, KRG-WE downregulated the expression of transcription factors and their protein levels associated with inflammation in lung and kidney of aged mice. KRG-WE also increased the expression of autophagy-related genes and their protein levels in colon, liver, and stomach. Conclusion: The results suggest that KRG can suppress inflammatory responses and recover autophagy activity in aged mice.

키워드

과제정보

This research was funded by the Korean society of ginseng (KSG) (2020) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF), Korea, the Ministry of Science and ICT, Republic of Korea (Grant No.: 2017R1A6A1A03015642).

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