DOI QR코드

DOI QR Code

The Relationship between Family History of Diabetes and Diabetes by BMI and Age in Korean Men and Women

  • Ko, Eunna (Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University) ;
  • Sull, Jae Woong (Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University)
  • Received : 2021.12.20
  • Accepted : 2021.12.28
  • Published : 2021.12.31

Abstract

Diabetes is mainly evaluated by fasting blood sugar. The genetic and environmental factors influence the development of type 2 diabetes. In this study, the relationship between diabetes and family history of diabetes in Koreans was analyzed in consideration of body mass index and age. The study subjects were 4,274 subjects who received a medical examination at a university hospital. The main statistical analysis method was multiple logistic regression analysis. In addition, subjects were analyzed by dividing them by gender and the median of age and body mass index. Diabetes prevalence was 8.9% of all subjects, and subjects with a family history of diabetes were 14.5%. The risk of diabetes was 2.80 times higher in subjects with a family history of diabetes than subjects without a family history of diabetes. In addition, in younger subjects, the risk of diabetes was 3.36 times higher in subjects with a family history of diabetes compared with subjects without a family history of diabetes. In this study, the family history of diabetes was significantly associated with diabetes. The relationship between family history of diabetes and diabetes was slightly higher in the younger group than in the older group. In order to obtain an accurate assessment of the association between diabetes and family history of diabetes, further prospective cohort study in the future is necessary.

Keywords

Acknowledgement

This paper was funded by the Basic Science Research Program of the National Research Foundation of Korea through the Ministry of Education, Science, and Technology (2018-R1D1A1B07050834) and funded by the Korea medical institute (KMI) in 2021.

References

  1. Cho ER, Jee YH, Kim SW, Sull JW. Effect of obesity on the association between MYL2 (rs3782889) and high-density lipoprotein cholesterol among Korean men. J Hum Genet. 2016. 61: 405-409. https://doi.org/10.1038/jhg.2015.165
  2. Downing KL, Hesketh KD, Timperio A, Salmon J, Moss K, Mishra G. Family history of non-communicable diseases and associations with weight and movement behaviours in Australian school-aged children: a prospective study. BMJ Open. 2020. 10: e038789. https://doi.org/10.1136/bmjopen-2020-038789
  3. Hilding A, Eriksson AK, Agardh EE, et al. The impact of family history of diabetes and lifestyle factors on abnormal glucose regulation in middle-aged Swedish men and women. Diabetologia. 2006. 49: 2589-2598. https://doi.org/10.1007/s00125-006-0402-5
  4. Jee SH, Sull JW, Park J, et al. Body-mass index and mortality in Korean men and women. N Engl J Med. 2006. 355: 779-787. https://doi.org/10.1056/NEJMoa054017
  5. Jee YH, Emberson J, Jung KJ, et al. Cohort Profile: The Korean Cancer Prevention Study-II (KCPS-II) Biobank. Int J Epidemiol. 2018. 47: 385-386f. https://doi.org/10.1093/ije/dyx226
  6. Kaprio J, Tuomilehto J, Koskenvuo M, et al. Concordance for type 1 (insulin-dependent) and type 2 (non-insulindependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia. 1992. 35: 1060-1067. https://doi.org/10.1007/BF02221682
  7. Kim EH, Bae SG, Kim KY, Na YJ. Impaired Fasting Glucose Rate by Diabetes Family History. J Health Info Stat. 2017. 42: 63-69. https://doi.org/10.21032/jhis.2017.42.1.63
  8. Korean Diabetes Association, Korea Centers for Disease Control and Prevention (KCDC). Diabetes fact sheet in Korea 2012. Available at www.diabetes.or.kr/temp/DiabetesFact%20sheet2012_en.pdf [Accessed on 2 January 2017].
  9. Narayan KMV, Kondal D, Kobes S, et al. Incidence of diabetes in South Asian young adults compared to Pima Indians. BMJ Open Diabetes Res Care. 2021. 9: e001988. https://doi.org/10.1136/bmjdrc-2020-001988
  10. Ning F, Pang Z, Laatikainen T, et al. Joint effect of family history of diabetes with obesity on prevalence of type 2 diabetes mellitus among Chinese and Finnish men and women. Can J Diabetes. 2013. 37: 65-71. https://doi.org/10.1016/j.jcjd.2012.12.001
  11. Ogata E, Asahi K, Yamaguchi S, et al. Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population. Sci Rep. 2018. 8: 13927. https://doi.org/10.1038/s41598-018-31744-4
  12. Okada H, Hamaguchi M, Habu M, et al. Association between variability in body mass index and development of type 2 diabetes: Panasonic cohort study. BMJ Open Diabetes Res Care. 2021. 9: e002123. https://doi.org/10.1136/bmjdrc-2021-002123
  13. Park HS, Jeong JG, Yu JH. The relationship between factors of meta\-bolic syndrome in Korean adult males and the parents' family history of diabetes. J Korea Inst Electron Commun Sci. 2013. 8: 779-784. https://doi.org/10.13067/JKIECS.2013.8.5.779
  14. Sakurai M, Nakamura K, Miura K, et al. Family history of diabetes, lifestyle factors, and the 7-year incident risk of type 2 diabetes mellitus in middle-aged Japanese men and women. J Diabetes Investig. 2013. 4: 261-268. https://doi.org/10.1111/jdi.12033
  15. Shaw JT, Purdie DM, Neil HA, Levy JC, Turner RC. The relative risks of hyperglycaemia, obesity and dyslipidaemia in the relatives of patients with Type II diabetes mellitus. Diabetologia. 1999. 42: 24-27. https://doi.org/10.1007/s001250051107
  16. Shim SY, Lee GB, Shim JS, Jung SJ, Kim HC. Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults. Epidemiol Health. 2021. 43: e2021049. https://doi.org/10.4178/epih.e2021049
  17. Song MG, Koh YH, Kim JB, Lee DA, Noh BR, Kim HJ. Association between Family History of Diabetes Mellitus and Health Behaviors among Korean Adults. Korean J Fam Pract. 2017. 7: 411-417. https://doi.org/10.21215/kjfp.2017.7.3.411
  18. Sull JW, Kim G, Jee SH. Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women. BMC Med Genet. 2020. 21: 160. https://doi.org/10.1186/s12881-020-01100-3
  19. Unwin N, Whiting D, Guariguata L, Ghyoot G, Gan D. IDF diabetes atlas. Brussels, Belgium: International Diabetes Federation. 2011. p. 11-74.
  20. Ustulin M, Rhee SY, Chon S, et al. Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population. Sci Rep. 2018. 8: 15958. https://doi.org/10.1038/s41598-018-34411-w
  21. Weijnen CF, Rich SS, Meigs JB, Krolewski AS, Warram JH. Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies. Diabet Med. 2002. 19: 41-50. https://doi.org/10.1046/j.1464-5491.2002.00624.x
  22. Ye C, Niu J, Zhao Z, et al. Genetic susceptibility, family history of diabetes and healthy lifestyle factors in relation to diabetes: A gene-environment interaction analysis in Chinese adults. J Diabetes Investig. 2021. 12: 2089-2098. https://doi.org/10.1111/jdi.13577
  23. Zhang H, Rogers K, Sukkar L, et al. Prevalence, incidence and risk factors of diabetes in Australian adults aged ≥45 years: A cohort study using linked routinely-collected data. J Clin Transl Endocrinol. 2020. 22: 100240.