대한의생명과학회지 (Biomedical Science Letters)

  • 제27권4호
  • /
  • Pages.231-238
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  • 2021
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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Synthesis of Tetrapeptide Derived from Skin Structural Protein Sequence and Identification of Skin Anti-aging Effect

  • 투고 : 2021.11.08
  • 심사 : 2021.12.10
  • 발행 : 2021.12.31
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초록

Several structural proteins present in keratinocytes of the skin are known to play an important role in the formation of epidermal tissue and barrier function, and the absence of structural proteins in keratinocytes causes various skin diseases. In this study, 42 types of tetrapeptides derived from the sequence of Loricrin, a kind of terminally differentiating structural protein, were synthesized, and skin anti-aging properties were measured by measuring the elastase inhibition, proliferation of skin cells. The anti-aging efficacy was verified and, based on this, it succeeded in selecting one of the most excellent peptides. It is expected that the selected tetrapeptide can be used as a raw material for various cosmetics and quasi-drugs based on anti-aging and skin cell proliferation effects.

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과제정보

This research was supported by the Ministry of Trade, Industry & Energy (MOTIE), Korea Evaluation Institute of Industrial Technology (KEIT) through the Encouragement Program for Bio industry core technology development project (Project NO: 20009105).

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