Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Enhancement of Antioxidant and Skin Cancer Inhibition Effects by Fermented Luffa aegyptiaca Extract

수세미오이 발효추출물의 항산화 및 피부암 억제 효과

  • Kim, Song Yi (Department of Food Science, Sun Moon University) ;
  • Gam, Da Hye (Department of Food Science, Sun Moon University) ;
  • Kim, Jun Hee (Department of Food Science, Sun Moon University) ;
  • Yeom, Suh Hee (Department of Food Science, Sun Moon University) ;
  • Park, Jae-Hyun (Department of Food Science, Sun Moon University) ;
  • Kim, Jin Woo (Department of Food Science, Sun Moon University)
  • 김송이 (선문대학교 식품과학과) ;
  • 감다혜 (선문대학교 식품과학과) ;
  • 김준희 (선문대학교 식품과학과) ;
  • 염서희 (선문대학교 식품과학과) ;
  • 박재현 (선문대학교 식품과학과) ;
  • 김진우 (선문대학교 식품과학과)
  • Received : 2020.11.09
  • Accepted : 2021.03.05
  • Published : 2021.03.31
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Abstract

This study aimed to improve the production of bioactive materials with antioxidant activity using a fermented Luffa aegyripia extract and improve the anticancer effect by enhancing UV absorption and inhibiting melanoma cell growth. The total phenolic content (TPC) and antioxidant activity of the fermented extract were 30.23 mg GAE/g DM and 45.12%, respectively, which was 1.4 times higher than that of the hot-water extract (HWE). The fermented extract showed a UV adsorption rate of 53.9%, which was 1.5 times higher than HWE, and it was concluded that UV absorption was increased by TPC, which was increased through the fermentation of L. aegyptiaca extracts using Lactobacillus. In the anticancer effect test, fermented and HWE extracts had carcinogenic effects of 1.0 and 2.0 mg/mL, respectively. This suggests that the increased antioxidant activity due to the increase in TPC caused by fermentation contributed to the anticancer effect. The UV absorption rate of fermented extracts was 2.4 times higher than HWE, giving them potential use as cosmetics and pharmaceutical materials with high polyphenol contents and antioxidant properties and skin cancer prevention.

본 연구의 목적은 수세미오이 추출물을 유산균을 이용한 발효를 통해 항산화 활성과 함께 생체 활성 물질의 생산을 중대하고 자외선 흡수 및 피부 흑색종 세포 성장 억제를 강화하여 피부암 예방 효과를 향상시키는 데 있다. 수세미오이 발효추출물의 총 폴리페놀(TPC)과 항산화 활성도가 30.23 mg GA/g DM와 45.12%로 열수추출물보다 약 1.4배 높은 수준으로 확인되었다. 자외선 흡수율에 있어 발효추출물은 열수추출물보다 1.5배 높은 53.9%의 흡수율을 보였는데 발효를 통해 증가된 TPC에 의해 UV 흡수가 증가했다는 결론을 도출하였다. 항암효과에 있어 발효추출물과 열수추출물에서 각각 1.0 와 2.0 mg/mL에서 피부 흑색종세포에 대한 성장저해 효과가 나타나 추출물 발효에 따른 항암효과가 증가했음을 알 수 있었다. 발효추출물의 자외선 흡수율에 있어 열수출물보다 2.4배 높아 피부암 예방효과가 예상되며, 수세미오이 발효를 통해 항산화, 자외선차단과 피부암 저해 효과를 가지는 화장품, 식품 및 의약품 소재 개발 가능할 것으로 사료된다.

Keywords

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