Imaging Science in Dentistry

Korean Academy of Oral and Maxillofacial Radiology (대한영상치의학회)
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CBCT imaging and histopathological characteristics of osteoradionecrosis and medication-related osteonecrosis of the jaw

  • Ogura, Ichiro (Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Minami, Yoshiyuki (Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Ono, Junya (Department of Pathology, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Kanri, Yoriaki (Department of Pathology, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Okada, Yasuo (Department of Pathology, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Igarashi, Kensuke (Department of Dental Materials Science, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Haga-Tsujimura, Maiko (Department of Histology, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Nakahara, Ken (Advanced Research Center, The Nippon Dental University School of Life Dentistry at Niigata) ;
  • Kobayashi, Eizaburo (Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Life Dentistry at Niigata)
  • Received : 2020.08.31
  • Accepted : 2020.10.28
  • Published : 2021.03.31
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Abstract

Purpose: The purpose of this study was to evaluate the cone-beam computed tomographic (CBCT) imaging and histopathological characteristics of osteoradionecrosis(ORN) and medication-related osteonecrosis of the jaw(MRONJ). Materials and Methods: Ten surgical specimens from segmental mandibulectomy (3 ORN and 7 MRONJ) were analyzed using CBCT. The CBCT parameters were as follows: high-resolution mode (tube voltage, 90.0 kV; tube current, 4.00 mA; rotation time, 16.8 s; field of view, 56 mm×56 mm; thickness, 0.099 mm). Histopathological characteristics were evaluated using histological slides of the surgical specimens. The Pearson chi-square test was used to compare ORN and MRONJ in terms of CBCT findings(internal texture, sequestrum, periosteal reaction and cortical perforation) and histopathological characteristics(necrotic bone, inflammatory cells, reactive bone formation, bacteria, Actinomyces, and osteoclasts). A P value less than 0.05 was considered to indicate statistical significance. Results: MRONJ showed periosteal reaction on CBCT more frequently than ORN (7 of 7 [100%] vs. 0 of 3 [0%], P<0.05). Regarding histopathological characteristics, MRONJ showed osteoclasts more frequently than ORN (6 of 7 [85.7%] vs. 0 of 3 [0%], P<0.05). Conclusion: This study evaluated the CBCT imaging and histopathological characteristics of ORN and MRONJ, and the findings suggest that CBCT could be useful for the evaluation of ORN and MRONJ.

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References

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