Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

  • Received : 2020.06.04
  • Accepted : 2021.03.04
  • Published : 2021.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care. Bacteria and several fungal species have shown resistance to antibiotics used in treatment to current medications. Therefore, it is a considerable field of interest in the design and development of novel compounds with antimicrobial activity. Methods: The compounds bearing a heterocyclic ring play an imperative role among other organic compounds with pharmacological activity used as drugs in human for control and cure of various infections. Thiadiazoles containing nitrogen-sulfur atom as part of their cyclic structure which shown wide-ranging application as structural units of biologically active molecules and are very useful intermediates in Medicinal Chemistry. Results: The effectiveness of the thiadiazole nucleus was established by the drugs currently used for the treatment of various infections. 1,3,4-Thiadiazoles and some of their derivatives are widely studied because of their broad spectrum of pharmacological activities. Conclusion: In the present work, a series of 1,3,4-Thiadiazole derivatives were synthesized by cyclization of a group of various benzaldehyde with thiosemicarbazide in the presence of various reagent like FeCl3, HCHO by losing a molecule of water. These derivatives were found to possess prominent antimicrobial activity.

Keywords

References

  1. Kaushal M, Kaur A. A review on some 2,5-disubstituted [1,3,4] thiadiazole substituted thiazolidinone derivatives as a potent antimicrobial agents. World J Pharm Res. 2016;5(6):1966-77.
  2. Mehta D, Taya P, Neetu. A review on the various biological activities of thiadiazole. Int J Pharm Pharm Sci. 2015;7(4):39-47.
  3. Rao MRK, Shil S. Some observations on thin layer chromatography technique. Int J Recent Technol Eng. 2019;8(2):1700-2. https://doi.org/10.35940/ijrte.B1010.078219
  4. Sandeep Kumar Reddy C, Azam Khan KK, Nagaraja C. A review on the determination of melting point measurement system. Int J Adv Res Electr Electron Instrum Eng. 2016;5(2):975-9.
  5. Furniss BS, Vogel AI. Vogel's textbook of practical organic chemistry. 5th ed. Harlow: Pearson/Prentice Hall; 2009. p. 236-8, 1204-10.
  6. Serban G, Stanasel O, Serban E, Bota S. 2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents. Drug Des Devel Ther. 2018;12:1545-66. https://doi.org/10.2147/DDDT.S155958
  7. Kaur P. 1,3,4-thiadiazole and its derivatives: a review on biological activities. Int J Univ Pharm Bio Sci. 2017;6(3):246-80.
  8. Abo‐Bakr AM, Hashem HE. New 1,3,4‐thiadiazole derivatives: synthesis, characterization, and antimicrobial activity. J Heterocycl Chem. 2019;56(3):1038-47. https://doi.org/10.1002/jhet.3489
  9. Parmar KC, Umrigar NH. Review article on synthesis of 1,3,4-thiadiazole derivatives and it's biological activity. J Chem Pharm Res. 2017;9(6):202-14.
  10. Adnan S, Mohammed AJ, Thamer H. Synthesis and identification of some derivatives of 1,3,4-thiadiazole. J Chem Pharm Res. 2015;7(10):1000-11.
  11. Sayed A, Zaki Y, Aish E. A convenient route for the synthesis of new thiadiazoles. Turk J Chem. 2016;40(1):184-91. https://doi.org/10.3906/kim-1505-13
  12. Syed MA, Reddy YRP, Chandrasekhar KB. Design, one-pot synthesis and biological evaluation of imidazo[2,1-b] [1,3,4] thiadiazole Derivatives for their anti-tubercular and antifungal activity. J App Pharm Sci. 2018;8(7):21-7. https://doi.org/10.7324/japs.2018.8704
  13. Jain AK, Sharma S, Vaidya A, Ravichandran V, Agrawal RK. 1,3,4-thiadiazole and its derivatives: a review on recent progress in biological activities. Chem Biol Drug Des. 2013;81(5):557-76. https://doi.org/10.1111/cbdd.12125