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Successful management of systemic lupus erythematosus with levamisole in a Dachshund dog

  • Kim, Dong-Hyun (Department of Veterinary Internal Medicine, Konkuk University Veterinary Medical Teaching Hospital) ;
  • Han, Hyun-Jung (Department of Veterinary Emergency, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Jung-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Received : 2020.06.23
  • Accepted : 2020.11.12
  • Published : 2021.03.31

Abstract

A 5-year-old neutered female Dachshund dog presented with a 3-month history of hyperthermia, skin lesions, and shifting lameness. Based on physical examination, blood tests, urinalysis, and radiographs, the dog was diagnosed with systemic lupus erythematosus. Clinical signs improved after administration of prednisolone and cyclosporine but relapsed after the prednisolone was reduced due to side effects. Oral levamisole was commenced and the other immunosuppressants were tapered over a period of 2 months and then stopped. Levamisole was retained as the sole therapy for an additional 2 months. Six months after discontinuation of all treatment, the patient remained in remission.

Keywords

References

  1. Fournel C, Chabanne L, Caux C, Faure JR, Rigal D, Magnol JP, Monier JC. Canine systemic lupus erythematosus. I: A study of 75 cases. Lupus 1992;1:133-139.
  2. Chabanne L, Fournel C, Caux C, Bernaud J, Bonnefond C, Monier JC, Rigal D. Abnormalities of lymphocyte subsets in canine systemic lupus erythematosus. Autoimmunity 1995;22:1-8. https://doi.org/10.3109/08916939508995293
  3. Renoux G. The general immunopharmacology of levamisole. Drugs 1980;20:89-99. https://doi.org/10.2165/00003495-198020020-00001
  4. Johnson KC, Mackin A. Canine immune-mediated polyarthritis: part 1: pathophysiology. J Am Anim Hosp Assoc 2012;48:12-17. https://doi.org/10.5326/JAAHA-MS-5744
  5. Symoens J, Rosenthal M, De Brabander M, Goldstein G. Immunoregulation with levamisole. Springer Semin Immunopathol 1979;2:49-68. https://doi.org/10.1007/BF00201973
  6. Nelson RW, Couto CG. Small Animal Internal Medicine. 6th ed. pp. 1247-1249, Elsevier Health Sciences, St. Louis, 2020.
  7. Costa NN, de Mello Bobany D, Veras de Mello ML, Tucunduva P. Systemic lupus erythematosus discoid in dog (Canis familiaris): case report. IOSR J Agric Vet Sci 2017;10:51-53. https://doi.org/10.9790/2380-1004025153
  8. Chong BF, Song J, Olsen NJ. Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus. Br J Dermatol 2012;166:29-35. https://doi.org/10.1111/j.1365-2133.2011.10610.x
  9. Mak A, Kow NY. The pathology of T cells in systemic lupus erythematosus. J Immunol Res 2014;2014:419029.
  10. Caielli S, Veiga DT, Balasubramanian P, Athale S, Domic B, Murat E, Banchereau R, Xu Z, Chandra M, Chung CH, Walters L, Baisch J, Wright T, Punaro M, Nassi L, Stewart K, Fuller J, Ucar D, Ueno H, Zhou J, Banchereau J, Pascual V. A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate. Nat Med 2019;25:75-81. https://doi.org/10.1038/s41591-018-0254-9
  11. von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T, Enghard P, Sawitzki B, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Humrich JY. Low-dose inter-leukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. Ann Rheum Dis 2016;75:1407-1415. https://doi.org/10.1136/annrheumdis-2015-207776
  12. Tsokos GC, Lo MS, Costa Reis P, Sullivan KE. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol 2016;12:716-730. https://doi.org/10.1038/nrrheum.2016.186
  13. Suarez G, Alvarez L, Castells D, Moreno L, Fagiolino P, Lanusse C. Evaluation of pharmacological interactions after administration of a levamisole, albendazole and ivermectin triple combination in lambs. Vet Parasitol 2014;201:110-119. https://doi.org/10.1016/j.vetpar.2013.12.015
  14. Reed SM, Furr M, Howe DK, Johnson AL, MacKay RJ, Morrow JK, Pusterla N, Witonsky S. Equine protozoal myeloencephalitis: an updated consensus statement with a focus on parasite biology, diagnosis, treatment, and prevention. J Vet Intern Med 2016;30:491-502. https://doi.org/10.1111/jvim.13834
  15. McCall JW, Arther R, Davis W, Settje T. Safety and efficacy of 10% imidacloprid+2.5% moxidectin for the treatment of Dirofilaria immitis circulating microfilariae in experimentally infected dogs. Vet Parasitol 2014;206:86-92. https://doi.org/10.1016/j.vetpar.2014.09.011