Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Anorexigenic peptide (leptin, obestatin, nesfatin-1) levels and their impact on assisted reproductive technology treatment outcomes in patients with polycystic ovary syndrome

  • Varli, Bulut (Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University) ;
  • Sukur, Yavuz Emre (Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University) ;
  • Ozmen, Batuhan (Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University) ;
  • Erguder, Berrin Imge (Department of Biochemistry, Faculty of Medicine, Ankara University) ;
  • Sonmezer, Murat (Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University) ;
  • Berker, Bulent (Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University) ;
  • Atabekoglu, Cem (Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University) ;
  • Aytac, Rusen (Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University)
  • Received : 2021.02.15
  • Accepted : 2021.07.28
  • Published : 2021.12.31
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Abstract

Objective: In this study we aimed to assess anorexigenic peptide levels in patients with or without polycystic ovary syndrome (PCOS) and their effects on assisted reproductive treatment (ART) outcomes. Methods: A prospective case-control study was conducted in a tertiary care university-based ART clinic. Eighty-three patients were included in the study. The PCOS group included 41 patients, and the non-PCOS group included 42 controls. The 2003 Rotterdam criteria were used for PCOS patient selection. The ART indications in the non-PCOS group were tubal factor or unexplained infertility. Venous blood samples were taken on the third day of the menstrual cycle to determine the serum anorexigenic peptide levels. The enzyme-linked immunosorbent assay method was used for laboratory analyses. Results: In the PCOS group, serum obestatin levels were significantly lower than in the control group, but serum anorexigenic peptide levels were similar in PCOS patients with or without clinical pregnancy. Ovarian hyperstimulation syndrome (OHSS) was diagnosed only in PCOS patients, and the obestatin levels of OHSS patients were significantly lower than those of other PCOS patients. Conclusion: Baseline anorexigenic peptide levels did not affect the clinical pregnancy rate in ART cycles. Obestatin may play a role in the pathophysiology of OHSS. This possibility should be confirmed in further research.

Keywords

Acknowledgement

This study was supported by Ankara University Scientific Research Project Coordination Unit (Project No.15H0230006).

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